Protein Alignment Octalpha2R and Octbeta3R

DIOPT Version :10

• Sequence 1: NP_001262715.1
• Gene: Octalpha2R / 42258
• FlyBaseID: FBgn0038653
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Alignment Length: 1255
• Identity: 234/1255 - (18%)
• Similarity: 358/1255 - (28%)
• Gaps: 586/1255 - (46%)

  Fly     4 SRLNANINTGNISTDDFLAVFSTGKPDNATLNPPLLSVDGQLTLPPGSGYVNVNDTIFFLNGSFY 68
            |.|.....||:|||.  .|..:|..|.:              :||..|.:|:.:.|...|..:..
  Fly    38 SHLQPATLTGHISTT--AAAKTTTTPTS--------------SLPITSQFVDASLTSLSLTATSS 86

  Fly    69 NSSLQLAAGFYNQSSASG---ATSGNLTNPNHTEVHWDGR---YPSGYTLTHIVIASIIVTILMI 127
            ::|.......|..|.::.   :|.|.....|.:::..|.:   ..|...|:.:::...|.:.:::
  Fly    87 DASYSSPFSSYLSSDSTFELLSTVGPNITANGSDIAVDNQAELEESWLDLSLLLLKGFIFSSIIL 151

  Fly   128 IIVVGNMLVIIAIATEKSLKNIQNWFIASLAVADFFLGLIIMPFSLANELM-GYWIFGSWWCDIH 191
            ..|:||.||||::...:.|:.|.|:|:.|||:||..:.|..|.|:.:.||. |.|:||.:.|:::
  Fly   152 AAVLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVY 216

  Fly   192 SAMDVLLCTASIMNLCLISLDRYWSITKAVDYLKSRTPARAAVMITAVWIMSALICIPPL-LGW- 254
            :::||...||||::||.||:|||::|.:.::|..:.|......|:..|||:.|||...|: |||
  Fly   217 NSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWY 281

  Fly   255 -------KVKM-PEGPLPKCELSEDIGYVLYSALGSFYIPSCIMVFVYIRIYFAAKARARRGI-- 309
                   ::.: |:    :|....:..|.|.|:..||:||..:|:.:|.|| |....|.|:.:
  Fly   282 TTEEHLREISLHPD----QCSFVVNKAYALISSSVSFWIPGIVMLVMYWRI-FKEAIRQRKALSR 341

  Fly   310 ----------------------------------------------------------------- 309
                                                                             
  Fly   342 TSSNILLNSVHMGHTQQPTSLSYLHPSDCDLNATSAREETHSALSNLEDMLQPATDEDDDRDECD 406

  Fly   310 ----------------------------------------------------------------- 309
                                                                             
  Fly   407 ELRVPSPPPRRLSRSSIDLRDLEQERYEKVTHTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWT 471

  Fly   310 -----------KKHPRKTNNEQVTSFTTAKKGTIPMPSSS------------------------- 338
                       |:|......:|..|.|:....:.|.|.|:
  Fly   472 EGKMIPSKELDKEHSHPNGPQQQLSLTSGSGNSEPEPESTAYRVFGGLNSDESEGNDLYDTHLPL 536

  Fly   339 ----------------------------------------------------------------- 338
                                                                             
  Fly   537 AEDNKELKRLIEDNYLYFKRQTGGTIISGPGGGKYAALSETDFIRLKAGAAACGRKAFASSDSEF 601

  Fly   339 --------------------GVSALQL------------------HQ------------------ 347
                                |.:.|.|                  ||
  Fly   602 LRTISESRALPEQPVPGKEKGFNILSLLSKTKRSSTECFTLEKKRHQANSEGSSFFRRSRNRKLS 666

  Fly   348 -----------------QRQIATIETPPNSASLPMQI--------PTVTMDLASDISTSEAGELE 387
                             |||.:..::.||...:.:.|        .:|....:..:...:..||:
  Fly   667 HSYNGCGGGKERKLERRQRQHSDTDSTPNKPDILLDINVLSEQSGASVIQQFSDGVQLIDFSELK 731

  Fly   388 A--------------------------------------------VAAQTVLA---------YAN 399
            .                                            :|:.:.||         ...
  Fly   732 TPPERIRSDDELAQLADCFGESPQQPATPPPSLSPPELPEPSGLLIASSSELAEIFRSLSFPLGR 796

  Fly   400 PNGA--------------------GTNSVTVVSSGNGG----------------------PGASG 422
            |.||                    .|.:...:|..|||                      |..:.
  Fly   797 PAGAPQRLSTLSDQVCANYLMSPPNTPAPPAISVPNGGAMDSSASSNAQSASINVYFLSPPPHAA 861

  Fly   423 VPPSSPKETLQVSTIATGRVGLNVPVP---PSMGSNSSIN-----VLNNNNGTVA---------- 469
            .|..:|.:|..||......:.:.||||   |.|.|.|:|:     :|::....|.
  Fly   862 APGYTPSDTSTVSLDVVTSLPMPVPVPQPNPQMASQSNISPKPEIILDSTLSPVEGCGDEHRDVT 926

  Fly   470 --------MDGGATAAGGGNGSAVATPGGLQQTGGNELRVSPIAG-------RCRALSVGVDTDM 519
                    ..|.|..:..|||.|    ||:...||.:.|.|.:||       |.|..||......
  Fly   927 SPLFKRKDSAGDADVSVSGNGGA----GGVGGVGGRQGRCSILAGYDGIQTVRKRQASVVTYDVN 987

  Fly   520 VSEFDPSSSDS----------------------------GV------------------VSRCAV 538
            |..|...:|||                            |:                  ::..||
  Fly   988 VINFSQENSDSRSYIPMGRVSTSSAKHEFSNKSSLIRRGGICIFVDEEEAEIIEQRPRGITFAAV 1052

  Fly   539 VKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQSS-----GVASKNQQQQQQQQQQQVVKSELE 598
            ..||.  .| |:.|...|:.........|..|..|:     ..:||....:|.....|      .
  Fly  1053 PSPLP--KC-PLCGADISSTTGTTANATATANADSTIDTTVTTSSKRSIHEQTPDLGQ------R 1108

  Fly   599 PAIPK-------------TPKPRDPEKEKRRIAR------------------KKEKRATLILGLI 632
            ||...             |...:..:..|||...                  |.|.:|...||:|
  Fly  1109 PASSSSSTRFWHKRTAAVTACWQQSKNRKRRFKTGCSHCGATGGSVRPAKGWKAEHKAARTLGII 1173

  Fly   633 MGSFIACWLPFFFLYILVPACSSHCNIPESAFAVAFWLGYMNSALNPAIYTIFNKDFRRAFRRIL 697
            ||.|:.||||||..|::...|...|..|:....|.||:||.||.|||.||..||:|||.|||..|
  Fly  1174 MGVFLLCWLPFFLWYVITSLCGPACPCPDVLVVVLFWIGYFNSTLNPLIYAYFNRDFREAFRNTL 1238

  Fly   698 FKXCLAYVCCYRCVYASIEK 717
                       .||...:||
  Fly  1239 -----------ECVLPCLEK 1247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octalpha2R	NP_001262715.1	7tmA_alpha2_AR	132..>307	CDD:320187	67/185 (36%)
		TM helix 2	150..176	CDD:320187	10/25 (40%)
		TM helix 3	188..218	CDD:320187	14/29 (48%)
		TM helix 4	230..253	CDD:320187	8/23 (35%)
		TM helix 5	271..300	CDD:320187	11/28 (39%)
		7tm_GPCRs	<616..693	CDD:475119	37/94 (39%)
		TM helix 6	626..648	CDD:410628	12/21 (57%)
		TM helix 7	661..686	CDD:410628	12/24 (50%)
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	70/200 (35%)
		TM helix 1	142..167	CDD:320194	8/24 (33%)
		TM helix 2	174..200	CDD:320194	10/25 (40%)
		TM helix 3	213..243	CDD:320194	14/29 (48%)
		TM helix 4	255..278	CDD:320194	8/22 (36%)
		TM helix 5	302..331	CDD:320194	12/29 (41%)
		7tm_GPCRs	<1161..1234	CDD:475119	36/72 (50%)
		TM helix 6	1167..1189	CDD:410628	12/21 (57%)
		TM helix 7	1202..1227	CDD:410628	12/24 (50%)