Protein Alignment Octalpha2R and 5-HT1B

DIOPT Version :9

• Sequence 1: NP_001262715.1
• Gene: Octalpha2R / 42258
• FlyBaseID: FBgn0038653
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 717
• Identity: 188/717 - (26%)
• Similarity: 312/717 - (43%)
• Gaps: 196/717 - (27%)

  Fly    44 QLTLPPGSGYVNVNDTIFF-LNGS---FYNSSLQLAAGFYNQSSASGATSGNLTNPNHTEVHWDG 104
            ::.||.    :.:|:::|. |||:   ..:::..|:...:|:|     .:|| .|.|..::..|.
  Fly    22 EIELPA----ILLNESLFIELNGNLTQLVDTTSNLSQIVWNRS-----INGN-GNSNTFDLVDDE 76

  Fly   105 RYPSG---YTLTHIVIASIIVTILMIIIVVGNMLVIIAIATEKSLKNIQNWFIASLAVADFFLGL 166
            :..:.   :.|..::..::::.:::::.::||:.||.||..|::|:|:.|:.:|||||||.|:..
  Fly    77 QERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVAC 141

  Fly   167 IIMPFSLANELMGYWIFGSWWCDIHSAMDVLLCTASIMNLCLISLDRYWSITKAVDYLKSRTPAR 231
            ::||.....|:...||.|...|||.::.|||.|||||::|..|:.||||::|. :||...|||.|
  Fly   142 LVMPLGAVYEISNGWILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-IDYNNLRTPRR 205

  Fly   232 AAVMITAVWIMSALICIPPLLGWK----VKMPEGPLPKCELSEDIGYVLYSALGSFYIPSCIMVF 292
            ..:||..||..:.::.:.|..|||    :|..|.  ..|.:|:|:||.:::...:||:|..:::|
  Fly   206 VFLMIFCVWFAALIVSLAPQFGWKDPDYMKRIEE--QHCMVSQDVGYQIFATCCTFYVPLLVILF 268

  Fly   293 VYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTTAKKGTIPMPSSSGVSALQLHQQRQIATIETP 357
            :|.:||..|:.|    |::..:|:.|..:|. |........:....  |..:..::|..|...||
  Fly   269 LYWKIYIIARKR----IQRRAQKSFNVTLTE-TDCDSAVRELKKER--SKRRAERKRLEAGERTP 326

  Fly   358 PNSASLPMQIPTVT-----------MDLASDISTSEAGELEAVAAQTV----LA----------- 396
            .:......|:...|           .:.|:.::.||.....::||..|    ||
  Fly   327 VDGDGTGGQLQRRTRKRMRICFGRNTNTANVVAGSEGAVARSMAAIAVDFASLAITREETEFSTS 391

  Fly   397 -YANPNGAGTNSVTVVSSGNGGPGASGVPPSSPKETLQVS------------------------T 436
             |.|.:.|||...||.|.      |.....|:..|.:.:|                        :
  Fly   392 NYDNKSHAGTELTTVSSD------ADDYRTSNANEIITLSQQVAHATQHHLIASHLNAITPLAQS 450

  Fly   437 IATGRVGLNVPVPPSMGSNSSINVLNNNNGTVAMDGGATAAGGGNGSAVATPGGLQQTGGNELRV 501
            ||.|.||......||..:.|..       ||||   ||.|.|.|:||.       ::..|.|
  Fly   451 IAMGGVGCLTTTTPSEKALSGA-------GTVA---GAVAGGSGSGSG-------EEGAGTE--- 495

  Fly   502 SPIAGRCRALSVGVDTDMVSEFDPSSSDSGVVSRCAVVKPLKFRLCQPIFGRKSSNQQRRNEAKA 566
                |:...:.:|                ||:
  Fly   496 ----GKNAGVGLG----------------GVL--------------------------------- 507

  Fly   567 AAKNQQSSGVASKNQQQQQQQQQQQVVKSELEPAIPKTPKPRDPEKEKRRIARKKEKRATLILGL 631
                   :.:|:.:|:.                           .|.::.:..|:|::|...|.:
  Fly   508 -------ASIANPHQKL---------------------------AKRRQLLEAKRERKAAQTLAI 538

  Fly   632 IMGSFIACWLPFFFLYILVPACSSHCNIPESAFAVAFWLGYMNSALNPAIYTIFNKDFRRAFRRI 696
            |.|:|:.||||||.:.:.:..| ..|.|..:..::..||||.||.|||.||||||.:|||||:||
  Fly   539 ITGAFVICWLPFFVMALTMSLC-KECEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRI 602

  Fly   697 LF 698
            ||
  Fly   603 LF 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octalpha2R	NP_001262715.1	7tm_1	132..>315	CDD:278431	73/186 (39%)
		7tm_4	133..>252	CDD:304433	52/118 (44%)
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	73/187 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940