| Sequence 1: | NP_001262715.1 | Gene: | Octalpha2R / 42258 | FlyBaseID: | FBgn0038653 | Length: | 740 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000855.1 | Gene: | HTR1D / 3352 | HGNCID: | 5289 | Length: | 377 | Species: | Homo sapiens |
| Alignment Length: | 623 | Identity: | 149/623 - (23%) |
|---|---|---|---|
| Similarity: | 223/623 - (35%) | Gaps: | 261/623 - (41%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 80 NQSSASG---ATSGNLTNPNHTEVHWDGRYPSGYTLTHIVIA-SIIVTILMIIIVVGNMLVIIAI 140
Fly 141 ATEKSLKNIQNWFIASLAVADFFLGLIIMPFSLANELMGYWIFGSWWCDIHSAMDVLLCTASIMN 205
Fly 206 LCLISLDRYWSITKAVDYLKSRTPARAAVMITAVWIMSALICIPPLLGWKVKMPEGPLPKCEL-S 269
Fly 270 EDIGYVLYSALGSFYIPSCIMVFVYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTTAKKGTIPM 334
Fly 335 PSSSGVSALQLHQQRQIATIETPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYAN 399
Fly 400 PNGAGTNSVTVVSSGNGGPGASGVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNN 464
Fly 465 NGTVAMDGGATAAGGGNGSAVATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVSEFDPSSSD 529
Fly 530 SGVVSRCAVVKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQQQQQQQVVK 594
Fly 595 SELEPAIPKTPKPRDPEKEKRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILVPACSSHCNI 659
Fly 660 PESAFAVAFWLGYMNSALNPAIYTIFNKDFRRAFRRIL 697 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Octalpha2R | NP_001262715.1 | 7tm_1 | 132..>315 | CDD:278431 | 72/183 (39%) |
| 7tm_4 | 133..>252 | CDD:304433 | 52/118 (44%) | ||
| HTR1D | NP_000855.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..23 | 7/18 (39%) | |
| 7tmA_5-HT1B_1D | 35..367 | CDD:320455 | 133/581 (23%) | ||
| TM helix 1 | 40..66 | CDD:320455 | 4/25 (16%) | ||
| TM helix 2 | 73..99 | CDD:320455 | 10/25 (40%) | ||
| TM helix 3 | 111..141 | CDD:320455 | 17/29 (59%) | ||
| Agonist binding. /evidence=ECO:0000250 | 114..123 | 1/8 (13%) | |||
| DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 | 135..137 | 1/1 (100%) | |||
| TM helix 4 | 153..176 | CDD:320455 | 12/23 (52%) | ||
| TM helix 5 | 194..223 | CDD:320455 | 14/28 (50%) | ||
| TM helix 6 | 294..324 | CDD:320455 | 16/29 (55%) | ||
| Agonist binding. /evidence=ECO:0000250 | 314..318 | 3/3 (100%) | |||
| TM helix 7 | 335..360 | CDD:320455 | 12/24 (50%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 352..356 | 2/3 (67%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3253 |
| SonicParanoid | 1 | 1.000 | - | - | X366 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.940 | |||||