| Sequence 1: | NP_001262715.1 | Gene: | Octalpha2R / 42258 | FlyBaseID: | FBgn0038653 | Length: | 740 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000854.1 | Gene: | HTR1B / 3351 | HGNCID: | 5287 | Length: | 390 | Species: | Homo sapiens |
| Alignment Length: | 622 | Identity: | 139/622 - (22%) |
|---|---|---|---|
| Similarity: | 222/622 - (35%) | Gaps: | 256/622 - (41%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 81 QSSASGATSGNLTNPNHTEVHWDGRYPSGYTLTHIVIASIIVTILMIIIVVGNMLVIIAIATEKS 145
Fly 146 LKNIQNWFIASLAVADFFLGLIIMPFSLANELMGYWIFGSWWCDIHSAMDVLLCTASIMNLCLIS 210
Fly 211 LDRYWSITKAVDYLKSRTPARAAVMITAVWIMSALICIPPLLGWKVKMPEGPLPKCELSED-IGY 274
Fly 275 VLYSALGSFYIPSCIMVFVYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTTAKKGTIPMPSSSG 339
Fly 340 VSALQLHQQRQIATIETPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYANPNGAG 404
Fly 405 TNSVTVVSSGNGGPGASGVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNNNGTVA 469
Fly 470 MDGGATAAGGGNGSAVATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVSEFDPSSSDSGVVS 534
Fly 535 RCAVVKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQQQQQQQVVKSELEP 599
Fly 600 AIPKTPKPRDPEKEKRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILVPACSSHCNIPESAF 664
Fly 665 AVAFWLGYMNSALNPAIYTIFNKDFRRAFRRILFKXC 701 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Octalpha2R | NP_001262715.1 | 7tm_1 | 132..>315 | CDD:278431 | 74/183 (40%) |
| 7tm_4 | 133..>252 | CDD:304433 | 54/118 (46%) | ||
| HTR1B | NP_000854.1 | 7tmA_5-HT1B_1D | 46..380 | CDD:320455 | 130/581 (22%) |
| TM helix 1 | 51..77 | CDD:320455 | 3/25 (12%) | ||
| TM helix 2 | 84..110 | CDD:320455 | 11/25 (44%) | ||
| TM helix 3 | 122..152 | CDD:320455 | 16/29 (55%) | ||
| Agonist binding | 125..134 | 1/8 (13%) | |||
| DRY motif, important for ligand-induced conformation changes and signaling | 146..148 | 1/1 (100%) | |||
| TM helix 4 | 164..187 | CDD:320455 | 12/23 (52%) | ||
| TM helix 5 | 205..234 | CDD:320455 | 12/28 (43%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 259..281 | 10/77 (13%) | |||
| TM helix 6 | 307..337 | CDD:320455 | 15/29 (52%) | ||
| Agonist binding | 327..331 | 3/3 (100%) | |||
| TM helix 7 | 348..373 | CDD:320455 | 12/24 (50%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling | 365..369 | 2/3 (67%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3253 |
| SonicParanoid | 1 | 1.000 | - | - | X366 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.940 | |||||