Protein Alignment Octalpha2R and adra2da

DIOPT Version :9

• Sequence 1: NP_001262715.1
• Gene: Octalpha2R / 42258
• FlyBaseID: FBgn0038653
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_919345.2
• Gene: adra2da / 266754
• ZFINID: ZDB-GENE-021010-4
• Length: 408
• Species: Danio rerio
• Alignment Length: 594
• Identity: 158/594 - (26%)
• Similarity: 238/594 - (40%)
• Gaps: 223/594 - (37%)

  Fly   110 YTLTHIVIASIIVTILMIIIVVGNMLVIIAIATEKSLKNIQNWFIASLAVADFFLGLIIMPFSLA 174
            ||.....|..::|::::::.:|||:|||:|:.|.::|:..||.|:.|||.||..:..:::|||||
Zfish    25 YTEPASAIIILVVSLIILLTIVGNVLVIVAVLTSRALRAPQNLFLVSLACADILVATLVIPFSLA 89

  Fly   175 NELMGYWIFGSWWCDIHSAMDVLLCTASIMNLCLISLDRYWSITKAVDYLKSRTPARAAVMITAV 239
            ||:||||.|||.||..:.|:|||.||:||::||.||||||||:||||.|...|||.|...||..|
Zfish    90 NEIMGYWYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVRYNLKRTPRRIKCMIAVV 154

  Fly   240 WIMSALICIPPLLGWKVKMPEGPLPKCELSEDIGYVLYSALGSFYIPSCIMVFVYIRIYFAAKAR 304
            |::||:|..|||:     |.:....:|.::::..|:|.|...||:.|..||:.||.:||..||.|
Zfish   155 WLISAVISFPPLI-----MTKHDEKECLINDETWYILSSCAVSFFAPGLIMITVYCKIYRVAKQR 214

  Fly   305 ------ARRGIKKHPRKTNNEQVTSFTTAKKGTIPMPSSSGVSALQLHQQRQIATIETPPNSASL 363
                  |:.|:::.|    ::..|.|....|.....|||:...:.|..::
Zfish   215 SSTVFVAKNGLERQP----SQSETCFVRKDKFEKESPSSNSSESAQRQEE--------------- 260

  Fly   364 PMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYANPNGAGTNSVTVVSSGNGGPGASGVPPSSP 428
                       ..||...|:
Zfish   261 -----------LDDIDLEES--------------------------------------------- 269

  Fly   429 KETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNNNGTVAMDGGATAAGGGNGSAVATPGGLQQ 493
                                                                             
Zfish   270 ----------------------------------------------------------------- 269

  Fly   494 TGGNELRVSPIAGRCRALSVGVDTDMVSEFDPSSSDSGVVSRCAVVKPLKFRLCQPIFGRKSSNQ 558
                                            ::|||..                     :.|..
Zfish   270 --------------------------------AASDSRA---------------------RGSRF 281

  Fly   559 QRRNEAKAAAKNQQSSGVASKNQQQQQQQQQQQVVKSELEPAIPKTPKPRDPEKEKRRIARKKEK 623
            .:|...:...:..|.|...|....|:...:|||:.                   .|.::|:.:||
Zfish   282 SKRRRVEGERRGPQRSCRVSWAAHQEPGSRQQQLA-------------------SKSKVAQMREK 327

  Fly   624 RATLILGLIMGSFIACWLPFFFLYILVPACSSHCNIPESAFAVAFWLGYMNSALNPAIYTIFNKD 688
            |.|.:|.::||.|:.||.||||.|.|...|...|..||:.|.:.||:||.||::||.||||||:|
Zfish   328 RFTFVLAVVMGVFVLCWFPFFFTYSLQAVCGERCGPPEALFKLFFWIGYCNSSVNPIIYTIFNRD 392

  Fly   689 FRRAFRRIL 697
            ||:||::::
Zfish   393 FRKAFKKVV 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octalpha2R	NP_001262715.1	7tm_1	132..>315	CDD:278431	89/188 (47%)
		7tm_4	133..>252	CDD:304433	67/118 (57%)
adra2da	NP_919345.2	7tm_4	45..>183	CDD:304433	72/142 (51%)
		7tm_1	47..386	CDD:278431	142/555 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..306		15/252 (6%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	289	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2469
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323202at33208
OrthoFinder	1	1.000	-	-		FOG0001303
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.160