Protein Alignment Octalpha2R and adra2c

DIOPT Version :9

• Sequence 1: NP_001262715.1
• Gene: Octalpha2R / 42258
• FlyBaseID: FBgn0038653
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_997522.1
• Gene: adra2c / 266752
• ZFINID: ZDB-GENE-021010-3
• Length: 432
• Species: Danio rerio
• Alignment Length: 611
• Identity: 184/611 - (30%)
• Similarity: 259/611 - (42%)
• Gaps: 205/611 - (33%)

  Fly    89 SGNLTNPNHTEVHWDGRYPSGYTLTHIVIASIIVTILMIIIVVGNMLVIIAIATEKSLKNIQNWF 153
            |||.||            .:.|:...|:..:.:|:.|::..:|||:||:||:.|.::||..||.|
Zfish    21 SGNSTN------------STSYSPATIIGLAGLVSFLILFTIVGNVLVVIAVLTSRALKPPQNLF 73

  Fly   154 IASLAVADFFLGLIIMPFSLANELMGYWIFGSWWCDIHSAMDVLLCTASIMNLCLISLDRYWSIT 218
            :.|||.||..:..:|:||||||||||||.||..||:|:.|:|||.||:||::||.||||||||:|
Zfish    74 LVSLASADILVATLIIPFSLANELMGYWFFGEVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVT 138

  Fly   219 KAVDYLKSRTPARAAVMITAVWIMSALICIPPLLGWKVKMPEGPLPKCELSEDIGYVLYSALGSF 283
            :||:|...|||.|...||..||::||:|..|||:.......:...|.|:|::...|:|||::|||
Zfish   139 QAVEYNLKRTPRRVKGMIVVVWLISAVISFPPLISMDRNTVDERRPMCQLNDHTWYILYSSIGSF 203

  Fly   284 YIPSCIMVFVYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTTAKKGTIPMPSSSGVSALQLHQQ 348
            :.|..||:.||||||..||.|.|                                     .:.::
Zfish   204 FAPCVIMILVYIRIYQVAKTRTR-------------------------------------NMSEK 231

  Fly   349 RQIATIETPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYANPNGAGTNSVTVVSS 413
            |:                                                :|:|
Zfish   232 RR------------------------------------------------DPDG----------- 237

  Fly   414 GNGGPGASGVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNNNGTVAMDGGATAAG 478
            |:|.|                                           ...||....|....
Zfish   238 GSGTP-------------------------------------------RLENGLSREDSRRE--- 256

  Fly   479 GGNGSAVATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVSEFDPSSSDSGVVSRCAVVKPLK 543
              ||...::||..:....|.                 |.|:.   |.||||
Zfish   257 --NGHCSSSPGERKPAEDNP-----------------DADLE---DSSSSD-------------- 285

  Fly   544 FRLCQPIFGRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQQQQQQQVVKSELEPAIPKTPKPR 608
                     .|:...|  ||...:.|:::||   .||....:...::....|:.........|.|
Zfish   286 ---------EKAKRSQ--NETAPSKKDRRSS---RKNSSSSKHSSRKSRASSKSLDLFSSRRKRR 336

  Fly   609 DPEKEKRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILVPACSSHCNIPESAFAVAFWLGYM 673
            :....| :|::.:|||.|.:|.::||.|:.||.||||.|.|...|...|.||:..|...||:||.
Zfish   337 NTISRK-KISQAREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGICREPCAIPDPLFKFFFWIGYC 400

  Fly   674 NSALNPAIYTIFNKDFRRAFRRILFK 699
            ||:|||.||||||:||||||::||.|
Zfish   401 NSSLNPVIYTIFNQDFRRAFQKILCK 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octalpha2R	NP_001262715.1	7tm_1	132..>315	CDD:278431	94/182 (52%)
		7tm_4	133..>252	CDD:304433	69/118 (58%)
adra2c	NP_997522.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		5/18 (28%)
		7tm_4	44..>233	CDD:304433	96/225 (43%)
		7tm_1	52..409	CDD:278431	159/549 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	224..342		35/309 (11%)
		DUF1777	224..>301	CDD:285811	27/265 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	289	1.000	Domainoid score	I1517
eggNOG	1	0.900	-	-		E33208_3BC1G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2469
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323202at33208
OrthoFinder	1	1.000	-	-		FOG0001303
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.970