Protein Alignment Octalpha2R and adra2b

DIOPT Version :9

• Sequence 1: NP_001262715.1
• Gene: Octalpha2R / 42258
• FlyBaseID: FBgn0038653
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_997521.1
• Gene: adra2b / 266751
• ZFINID: ZDB-GENE-021010-2
• Length: 510
• Species: Danio rerio
• Alignment Length: 647
• Identity: 207/647 - (31%)
• Similarity: 288/647 - (44%)
• Gaps: 161/647 - (24%)

  Fly    69 NSSLQLAAGFYNQSSASGATSGNLTNPNHTEVHWDGRYPSGYTLTHIVIASIIVTILMIIIVVGN 133
            :|...:|.|....::.:|.||....|.:..::       :.|:.......:..:|::|:|.:|||
Zfish     2 DSPCPVAVGLPGHTNGTGGTSSPTCNQSMIKL-------APYSPEATAAFATAITLMMLITIVGN 59

  Fly   134 MLVIIAIATEKSLKNIQNWFIASLAVADFFLGLIIMPFSLANELMGYWIFGSWWCDIHSAMDVLL 198
            :|||||:.|.:||:..||.|:.|||.||..:..:|:||||||||||||.|.|.||:|:.|:|||.
Zfish    60 ILVIIAVLTSRSLRGPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRSVWCEIYLALDVLF 124

  Fly   199 CTASIMNLCLISLDRYWSITKAVDYLKSRTPARAAVMITAVWIMSALICIPPLLGW---KVKMPE 260
            ||:||::||.||||||.||::||.|...|||.|....|..||::||:|..||||..   |.....
Zfish   125 CTSSIVHLCAISLDRYMSISRAVTYGPKRTPKRIKCAILVVWLISAVISFPPLLSMNKNKGGGES 189

  Fly   261 GPLPKCELSEDIGYVLYSALGSFYIPSCIMVFVYIRIYFAAKARAR----RGIKKHPRKTNNEQ- 320
            |.||:|:|:::..|:|||.:|||:.|..||:.||:|||..||.|.|    ...|:.|......|
Zfish   190 GALPQCQLNDERWYILYSTIGSFFAPCLIMILVYMRIYQIAKQRTRCPPGEPRKEAPANATTPQH 254

  Fly   321 --------VTSFTTAKKGTIPMPSSSGVSALQLHQQRQIATIETPPNSASLPMQIPTVTMDLASD 377
                    .|..|..||...|..:.|.|.::|     |.|  .||  .|:..:|.|:.|:...:.
Zfish   255 KIQNGRGDETPGTLQKKARPPTLAVSQVESVQ-----QAA--NTP--IANNLLQAPSTTLTPTTP 310

  Fly   378 ISTSEAGELEAVAAQTVLAYANPNGAGTNSVTVVSSGNGGPGASGVPPSSPKETLQVSTIATGRV 442
            .                     |:.:.:||             |.|.||..||
Zfish   311 C---------------------PSPSPSNS-------------SEVAPSKSKE------------ 329

  Fly   443 GLNVPVPPSMGSNSSINVLNNNNGTVAMDGGATAAGGGNGSAVATPGGLQQTGGNELRVSPIAGR 507
            |...........|.:....:||||. :|...:....||.|..|.
Zfish   330 GKKEKKKKKNNKNKNKKEPDNNNGE-SMSSDSDTEQGGRGLEVP--------------------- 372

  Fly   508 CRALSVGVDTDMVSEFDPSSSDSGVVSRCAVVKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQ 572
            |               .|:.:.||:.|                    .:..|:..:..|.||..:
Zfish   373 C---------------TPTMTPSGIHS--------------------PATMQKYRDMIATAKGAK 402

  Fly   573 SSGVASKNQQQQQQQQQQQVVKSELEPAIPKTPKPRDPEKEKRRIARKKEKRATLILGLIMGSFI 637
            .  ||.|.:|.                        ..|...:|:....:|||.|.:|.:::|.|:
Zfish   403 L--VARKAKQD------------------------GTPNSARRKAMVNREKRFTFVLAVVIGVFV 441

  Fly   638 ACWLPFFFLYILVPACSSHCNIPESAFAVAFWLGYMNSALNPAIYTIFNKDFRRAFRRILFK 699
            .||.||||.|.|...|...|.:||..|...||:||.||.|||.|||||||||||||::||.|
Zfish   442 ICWFPFFFSYSLQAVCPESCALPEPLFKFFFWIGYCNSCLNPVIYTIFNKDFRRAFKKILCK 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octalpha2R	NP_001262715.1	7tm_1	132..>315	CDD:278431	98/189 (52%)
		7tm_4	133..>252	CDD:304433	68/118 (58%)
adra2b	NP_997521.1	7tm_4	50..>178	CDD:304433	72/127 (57%)
		7tm_1	58..>244	CDD:278431	96/185 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..284		11/49 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..385		27/187 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	289	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2469
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323202at33208
OrthoFinder	1	1.000	-	-		FOG0001303
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.070