DRSC/TRiP Functional Genomics Resources

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Protein Alignment Octalpha2R and Adra2c

DIOPT Version :10

Sequence 1:NP_001262715.1 Gene:Octalpha2R / 42258 FlyBaseID:FBgn0038653 Length:740 Species:Drosophila melanogaster
Sequence 2:NP_612515.2 Gene:Adra2c / 24175 RGDID:2058 Length:458 Species:Rattus norvegicus


Alignment Length:628 Identity:191/628 - (30%)
Similarity:262/628 - (41%) Gaps:204/628 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 NQSSASGATSGNLTNPNHTEVHWDGRYPSGYTLTHIVIASIIVTILMIIIVVGNMLVIIAIATEK 144
            |.|.|....||...|.:.|:  | |..|..|:...:...:.:|..|::..||||:||:||:.|.:
  Rat    19 NGSDAGEWGSGGGANASGTD--W-GPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSR 80

  Fly   145 SLKNIQNWFIASLAVADFFLGLIIMPFSLANELMGYWIFGSWWCDIHSAMDVLLCTASIMNLCLI 209
            :|:..||.|:.|||.||..:..::||||||||||.||.||..||.::.|:|||.||:||::||.|
  Rat    81 ALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAI 145

  Fly   210 SLDRYWSITKAVDYLKSRTPARAAVMITAVWIMSALICIPPLLGWKVKMPEG-PLPKCELSEDIG 273
            |||||||:|:||:|...|||.|....|.|||::||:|..|||:.: .:.|:| ..|:|.|:::..
  Rat   146 SLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSF-YRRPDGAAYPQCGLNDETW 209

  Fly   274 YVLYSALGSFYIPSCIMVFVYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTTAKKGTIPMPSSS 338
            |:|.|.:|||:.|..||..||.|||..||.|.|         |.:|        |:|    |:. 
  Rat   210 YILSSCIGSFFAPCLIMGLVYARIYRVAKLRTR---------TLSE--------KRG----PAG- 252

  Fly   339 GVSALQLHQQRQIATIETPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYANPNGA 403
                               |:.||     ||                             ..||.
  Rat   253 -------------------PDGAS-----PT-----------------------------TENGL 264

  Fly   404 GTNSVTVVSSGNGGPGASGVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNNNGTV 468
            |.      ::|..|..|   ||.:..|.                      ..||........|.:
  Rat   265 GK------AAGENGHCA---PPRTEVEP----------------------DESSAAERRRRRGAL 298

  Fly   469 AMDG-------GATAAGGGNGSAVATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVSEFDPS 526
            ...|       |.|.:..|.|     ||...:.|......||..|                    
  Rat   299 RRGGRRREGAEGDTGSADGPG-----PGLAAEQGARTASRSPGPG-------------------- 338

  Fly   527 SSDSGVVSRCAVVKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQQQQQQQ 591
                                     ||.|....|..|...:.:.:..|.|.              
  Rat   339 -------------------------GRLSRASSRSVEFFLSRRRRARSSVC-------------- 364

  Fly   592 VVKSELEPAIPKTPKPRDPEKEKRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILVPACSSH 656
                                  :|::|:.:|||.|.:|.::||.|:.||.||||.|.|...|...
  Rat   365 ----------------------RRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREA 407

  Fly   657 CNIPESAFAVAFWLGYMNSALNPAIYTIFNKDFRRAFRRILFK 699
            |.:||..|...||:||.||:|||.|||:||:||||:|:.|||:
  Rat   408 CQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFR 450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Octalpha2RNP_001262715.1 7tmA_alpha2_AR 132..>307 CDD:320187 90/175 (51%)
TM helix 2 150..176 CDD:320187 14/25 (56%)
TM helix 3 188..218 CDD:320187 19/29 (66%)
TM helix 4 230..253 CDD:320187 11/22 (50%)
TM helix 5 271..300 CDD:320187 14/28 (50%)
7tm_GPCRs <616..693 CDD:475119 40/76 (53%)
TM helix 6 626..648 CDD:410628 11/21 (52%)
TM helix 7 661..686 CDD:410628 14/24 (58%)
Adra2cNP_612515.2 7tmA_alpha2C_AR 60..444 CDD:320446 175/576 (30%)
TM helix 2 86..112 CDD:320446 14/25 (56%)
TM helix 3 124..154 CDD:320446 19/29 (66%)
TM helix 4 166..189 CDD:320446 11/22 (50%)
TM helix 5 207..236 CDD:320446 14/28 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 245..343 34/244 (14%)
TM helix 6 371..401 CDD:320446 15/29 (52%)
TM helix 7 412..437 CDD:320446 14/24 (58%)

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