Protein Alignment Octalpha2R and Adra2c

DIOPT Version :9

• Sequence 1: NP_001262715.1
• Gene: Octalpha2R / 42258
• FlyBaseID: FBgn0038653
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_612515.2
• Gene: Adra2c / 24175
• RGDID: 2058
• Length: 458
• Species: Rattus norvegicus
• Alignment Length: 628
• Identity: 191/628 - (30%)
• Similarity: 262/628 - (41%)
• Gaps: 204/628 - (32%)

  Fly    80 NQSSASGATSGNLTNPNHTEVHWDGRYPSGYTLTHIVIASIIVTILMIIIVVGNMLVIIAIATEK 144
            |.|.|....||...|.:.|:  | |..|..|:...:...:.:|..|::..||||:||:||:.|.:
  Rat    19 NGSDAGEWGSGGGANASGTD--W-GPPPGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSR 80

  Fly   145 SLKNIQNWFIASLAVADFFLGLIIMPFSLANELMGYWIFGSWWCDIHSAMDVLLCTASIMNLCLI 209
            :|:..||.|:.|||.||..:..::||||||||||.||.||..||.::.|:|||.||:||::||.|
  Rat    81 ALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAI 145

  Fly   210 SLDRYWSITKAVDYLKSRTPARAAVMITAVWIMSALICIPPLLGWKVKMPEG-PLPKCELSEDIG 273
            |||||||:|:||:|...|||.|....|.|||::||:|..|||:.: .:.|:| ..|:|.|:::..
  Rat   146 SLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSF-YRRPDGAAYPQCGLNDETW 209

  Fly   274 YVLYSALGSFYIPSCIMVFVYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTTAKKGTIPMPSSS 338
            |:|.|.:|||:.|..||..||.|||..||.|.|         |.:|        |:|    |:.
  Rat   210 YILSSCIGSFFAPCLIMGLVYARIYRVAKLRTR---------TLSE--------KRG----PAG- 252

  Fly   339 GVSALQLHQQRQIATIETPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYANPNGA 403
                               |:.||     ||                             ..||.
  Rat   253 -------------------PDGAS-----PT-----------------------------TENGL 264

  Fly   404 GTNSVTVVSSGNGGPGASGVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNNNGTV 468
            |.      ::|..|..|   ||.:..|.                      ..||........|.:
  Rat   265 GK------AAGENGHCA---PPRTEVEP----------------------DESSAAERRRRRGAL 298

  Fly   469 AMDG-------GATAAGGGNGSAVATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVSEFDPS 526
            ...|       |.|.:..|.|     ||...:.|......||..|
  Rat   299 RRGGRRREGAEGDTGSADGPG-----PGLAAEQGARTASRSPGPG-------------------- 338

  Fly   527 SSDSGVVSRCAVVKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQQQQQQQ 591
                                     ||.|....|..|...:.:.:..|.|.
  Rat   339 -------------------------GRLSRASSRSVEFFLSRRRRARSSVC-------------- 364

  Fly   592 VVKSELEPAIPKTPKPRDPEKEKRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILVPACSSH 656
                                  :|::|:.:|||.|.:|.::||.|:.||.||||.|.|...|...
  Rat   365 ----------------------RRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREA 407

  Fly   657 CNIPESAFAVAFWLGYMNSALNPAIYTIFNKDFRRAFRRILFK 699
            |.:||..|...||:||.||:|||.|||:||:||||:|:.|||:
  Rat   408 CQLPEPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFR 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octalpha2R	NP_001262715.1	7tm_1	132..>315	CDD:278431	91/183 (50%)
		7tm_4	133..>252	CDD:304433	66/118 (56%)
Adra2c	NP_612515.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..343		34/244 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	276	1.000	Domainoid score	I1673
eggNOG	1	0.900	-	-		E33208_3BC1G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2473
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323202at33208
OrthoFinder	1	1.000	-	-		FOG0001303
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.970