Protein Alignment Octalpha2R and Adra2b

DIOPT Version :9

• Sequence 1: NP_001262715.1
• Gene: Octalpha2R / 42258
• FlyBaseID: FBgn0038653
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_612514.2
• Gene: Adra2b / 24174
• RGDID: 2057
• Length: 453
• Species: Rattus norvegicus
• Alignment Length: 611
• Identity: 190/611 - (31%)
• Similarity: 270/611 - (44%)
• Gaps: 189/611 - (30%)

  Fly   108 SGYTLTH---------IVIASIIVTILMIIIVVGNMLVIIAIATEKSLKNIQNWFIASLAVADFF 163
            ||.|:.|         ..|||.| |.|::..:.||.|||:|:.|.:||:..||.|:.|||.||..
  Rat     2 SGPTMDHQEPYSVQATAAIASAI-TFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADIL 65

  Fly   164 LGLIIMPFSLANELMGYWIFGSWWCDIHSAMDVLLCTASIMNLCLISLDRYWSITKAVDYLKSRT 228
            :..:|:||||||||:|||.|...||:::.|:|||.||:||::||.|||||||::::|::|...||
  Rat    66 VATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRT 130

  Fly   229 PARAAVMITAVWIMSALICIPPLL--GWKVKMPEGPLPKCELSEDIGYVLYSALGSFYIPSCIMV 291
            |.|...:|..||:::|:|.:|||:  |.:...|.| ||:|||:::..|:|.|::|||:.|..||:
  Rat   131 PRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRG-LPQCELNQEAWYILASSIGSFFAPCLIMI 194

  Fly   292 FVYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTTAKKGT------IPMPSSSGVSALQLHQQRQ 350
            .||:|||..||....||:                .||:|:      .|.|.:.||
  Rat   195 LVYLRIYVIAKRSHCRGL----------------GAKRGSGEGESKKPQPVAGGV---------- 233

  Fly   351 IATIETPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYANPNGAGTNSVTVVSSGN 415
                   |.||    ::||:...|:|                                  |...|
  Rat   234 -------PTSA----KVPTLVSPLSS----------------------------------VGEAN 253

  Fly   416 GGPGASGVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNNNGTVAMDGGATAAGGG 480
            |.|     .|...||..:.......|.     :||:.                     :.....|
  Rat   254 GHP-----KPPREKEEGETPEDPEARA-----LPPTW---------------------SALPRSG 287

  Fly   481 NGSAVATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVSEFDPSSSDSGVVSRCAVVKPLKFR 545
            .|....|.|...:.|..|                 |.:.|.|.:|.:..:...|.|.  .||:
  Rat   288 QGQKKGTSGATAEEGDEE-----------------DEEEVEECEPQTLPASPASVCN--PPLQ-- 331

  Fly   546 LCQPIFGRKSSNQQRRNEAKAAAKNQ----QSSGVASKNQQQQQQQQQQQVVKSELEPAIPKTPK 606
                        |.:.:...|..:.|    ::.||||
  Rat   332 ------------QPQTSRVLATLRGQVLLGKNVGVAS---------------------------- 356

  Fly   607 PRDPEKEKRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILVPACSSHCNIPESAFAVAFWLG 671
               .:..:||....:|||.|.:|.:::|.|:.||.||||.|.|...|..||.:|...|...||:|
  Rat   357 ---GQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIG 418

  Fly   672 YMNSALNPAIYTIFNKDFRRAFRRIL 697
            |.||:|||.|||:||:||||||||||
  Rat   419 YCNSSLNPVIYTVFNQDFRRAFRRIL 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octalpha2R	NP_001262715.1	7tm_1	132..>315	CDD:278431	89/184 (48%)
		7tm_4	133..>252	CDD:304433	61/118 (52%)
Adra2b	NP_612514.2	7tm_4	26..>157	CDD:304433	64/130 (49%)
		7tm_1	34..429	CDD:278431	165/561 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..331		37/222 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	276	1.000	Domainoid score	I1673
eggNOG	1	0.900	-	-		E33208_3BC1G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2473
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323202at33208
OrthoFinder	1	1.000	-	-		FOG0001303
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.970