Protein Alignment Octalpha2R and ser-7

DIOPT Version :9

• Sequence 1: NP_001262715.1
• Gene: Octalpha2R / 42258
• FlyBaseID: FBgn0038653
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_741730.1
• Gene: ser-7 / 180565
• WormBaseID: WBGene00004780
• Length: 435
• Species: Caenorhabditis elegans
• Alignment Length: 590
• Identity: 139/590 - (23%)
• Similarity: 201/590 - (34%)
• Gaps: 247/590 - (41%)

  Fly   117 IASIIVTILMIIIVVGNMLVIIAIATEKSLKNIQNWFIASLAVADFFLGLIIMPFSLANELMGYW 181
            :.:|.:..::|:..|||.||.:|:...:.||:.||:.:.||||||||:||::||.:|.:.|...|
 Worm    43 LLAIAILAMIIMTTVGNALVCLAVLLVRKLKHPQNFLLVSLAVADFFVGLVVMPLALIDLLFDKW 107

  Fly   182 IFGSWWCDIHSAMDVLLCTASIMNLCLISLDRYWSITKAVDYLKSRTPARAAVMITAVWIMSALI 246
            ..||..|.:::..|:.||||||:|||.||:|||..|:..:.|...||..|..:.|..|||::|::
 Worm   108 PLGSTMCSVYTTSDLTLCTASIVNLCAISVDRYLVISSPLRYSAKRTTKRIMMYIACVWIIAAIV 172

  Fly   247 CIPP-----LLGWKVKMPEGPLPKCELSEDIGYVLYSALGSFYIPSCIMVFVYIRIYFAAKARAR 306
            .|..     ||.....:.:  ...|::.....|..|:.:.|||.|:.|||.:.|:|:.|||..|.
 Worm   173 SISSHIIANLLNDGTYVDD--TGTCQVIPHFIYQSYATIISFYAPTFIMVILNIKIWRAAKRLAA 235

  Fly   307 RGIKKHPRKTNNEQVTSFTTAKKGTIPMPSSSGVSALQLHQQRQIATIETPPNSASLPMQIPTVT 371
            :                                 ..|..| ...:...|.|.|.::       .|
 Worm   236 Q---------------------------------DRLMSH-CNSVDASERPRNGSA-------ET 259

  Fly   372 MDLASDISTSEAGELEAVAAQTVLAYANPNGAGTNSVTVVSSGNGGPGASGVPPSSPKETLQVST 436
            .|..::                                                   |||
 Worm   260 KDFLNE---------------------------------------------------KET----- 268

  Fly   437 IATGRVGLNVPVPPSMGSNSSINVLNNNNGTVAMDGGATAAGGGNGSAVATPGGLQQTGGNELRV 501
                     :.||....:||:.:.|
 Worm   269 ---------IDVPKKERANSTNSRL---------------------------------------- 284

  Fly   502 SPIAGRCRALSVGVDTDMVSEFDPSSSDSGVVSRCAVVKPLKFRLCQPIFGRKSSNQQRRNEAKA 566
                                                      |:|.:....|.|:       ..:
 Worm   285 ------------------------------------------FKLERKYLHRPSA-------FFS 300

  Fly   567 AAKNQQSSGVASKNQQQQQQQQQQQVVKSELEPAIPKTPKPRDPEKEKRRIARKKEKRATLILGL 631
            |||.                            |.|.:|              .|.|.:|...||:
 Worm   301 AAKG----------------------------PLIRQT--------------EKSECKARKTLGV 323

  Fly   632 IMGSFIACWLPFFFLYILVPACSSHCNIPESAFAVAFWLGYMNSALNPAIYTIFNKDFRRAFRRI 696
            ||..||.||||||.|.|..   |....||:....:|.||||.||.|||.||..:||:||..||.:
 Worm   324 IMSVFIICWLPFFILAIFK---SFGMWIPDWLDLLALWLGYSNSTLNPLIYCKYNKEFRIPFREM 385

  Fly   697 LFKXC 701
            |...|
 Worm   386 LACRC 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octalpha2R	NP_001262715.1	7tm_1	132..>315	CDD:278431	71/187 (38%)
		7tm_4	133..>252	CDD:304433	52/123 (42%)
ser-7	NP_741730.1	7tmA_5-HT7	42..382	CDD:320452	135/580 (23%)
		TM helix 1	44..68	CDD:320452	8/23 (35%)
		TM helix 2	77..99	CDD:320452	13/21 (62%)
		TM helix 3	115..137	CDD:320452	11/21 (52%)
		TM helix 4	160..176	CDD:320452	6/15 (40%)
		TM helix 5	201..224	CDD:320452	9/22 (41%)
		TM helix 6	315..340	CDD:320452	14/24 (58%)
		TM helix 7	350..375	CDD:320452	12/24 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167495
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3253
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870