| Sequence 1: | NP_001262715.1 | Gene: | Octalpha2R / 42258 | FlyBaseID: | FBgn0038653 | Length: | 740 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001272411.1 | Gene: | Htr1d / 15552 | MGIID: | 96276 | Length: | 374 | Species: | Mus musculus |
| Alignment Length: | 597 | Identity: | 145/597 - (24%) |
|---|---|---|---|
| Similarity: | 212/597 - (35%) | Gaps: | 255/597 - (42%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 102 WDGRYPSGYTLTHIVIASIIVTILMIIIVVGNMLVIIAIATEKSLKNIQNWFIASLAVADFFLGL 166
Fly 167 IIMPFSLANELMGYWIFGSWWCDIHSAMDVLLCTASIMNLCLISLDRYWSITKAVDYLKSRTPAR 231
Fly 232 AAVMITAVWIMSALICIPPLLGWKVKMPEGPLPKCEL-SEDIGYVLYSALGSFYIPSCIMVFVYI 295
Fly 296 RIYFAAKARARRGIKKHPRKTNNEQVTSFTTAKKGTIPMPSSSGVSALQLHQQRQIATIETPPNS 360
Fly 361 ASLPMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYANPNGAGTNSVTVVSSGNGGPGASGVPP 425
Fly 426 SSPKETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNNNGTVAMDGGATAAGGGNGSAVATPGG 490
Fly 491 LQQTGGNELRVSPIAGRCRALSVGVDTDMVSEFDPSSSDSGVVSRCAVVKPLKFRLCQPIFGRKS 555
Fly 556 SNQQRRNEAKAAAKNQQSSGVASKNQQQQQQQQQQQVVKSELEPAIPKTPKPRDPEKEKRRIARK 620
Fly 621 KEKRATLILGLIMGSFIACWLPFFFLYILVPACSSHCNIPESAFAVAFWLGYMNSALNPAIYTIF 685
Fly 686 NKDFRRAFRRIL 697 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Octalpha2R | NP_001262715.1 | 7tm_1 | 132..>315 | CDD:278431 | 75/183 (41%) |
| 7tm_4 | 133..>252 | CDD:304433 | 55/118 (47%) | ||
| Htr1d | NP_001272411.1 | 7tm_GPCRs | 32..364 | CDD:391938 | 141/585 (24%) |
| TM helix 1 | 38..62 | CDD:341315 | 7/27 (26%) | ||
| TM helix 2 | 71..93 | CDD:341315 | 8/21 (38%) | ||
| TM helix 3 | 109..131 | CDD:341315 | 11/21 (52%) | ||
| Agonist binding. /evidence=ECO:0000250 | 111..120 | 1/8 (13%) | |||
| DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 | 132..134 | 1/1 (100%) | |||
| TM helix 4 | 154..170 | CDD:341315 | 9/15 (60%) | ||
| TM helix 5 | 192..215 | CDD:341315 | 10/22 (45%) | ||
| TM helix 6 | 294..319 | CDD:341315 | 14/24 (58%) | ||
| Agonist binding. /evidence=ECO:0000250 | 311..315 | 3/3 (100%) | |||
| TM helix 7 | 332..357 | CDD:341315 | 12/24 (50%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 349..353 | 2/3 (67%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3253 |
| SonicParanoid | 1 | 1.000 | - | - | X366 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.940 | |||||