| Sequence 1: | NP_001262715.1 | Gene: | Octalpha2R / 42258 | FlyBaseID: | FBgn0038653 | Length: | 740 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_034612.1 | Gene: | Htr1b / 15551 | MGIID: | 96274 | Length: | 386 | Species: | Mus musculus |
| Alignment Length: | 620 | Identity: | 143/620 - (23%) |
|---|---|---|---|
| Similarity: | 220/620 - (35%) | Gaps: | 251/620 - (40%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 84 ASGATSGNLTNPNHTEVHWDGR-YPSGYTLTHIVIASIIVTILMIIIVVGNMLVIIAIATEKSLK 147
Fly 148 NIQNWFIASLAVADFFLGLIIMPFSLANELMGYWIFGSWWCDIHSAMDVLLCTASIMNLCLISLD 212
Fly 213 RYWSITKAVDYLKSRTPARAAVMITAVWIMSALICIPPLLGWKVKMPEGPLPKCELSED-IGYVL 276
Fly 277 YSALGSFYIPSCIMVFVYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTTAKKGTIPMPSSSGVS 341
Fly 342 ALQLHQQRQIATIETPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYANPNGAGTN 406
Fly 407 SVTVVSSGNGGPGASGVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNNNGTVAMD 471
Fly 472 GGATAAGGGNGSAVATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVSEFDPSSSDSGVVSRC 536
Fly 537 AVVKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQQQQQQQVVKSELEPAI 601
Fly 602 PKTPKPRDPEKEKRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILVPACSSHCNIPESAFAV 666
Fly 667 AFWLGYMNSALNPAIYTIFNKDFRRAFRRILFKXC 701 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Octalpha2R | NP_001262715.1 | 7tm_1 | 132..>315 | CDD:278431 | 73/183 (40%) |
| 7tm_4 | 133..>252 | CDD:304433 | 54/118 (46%) | ||
| Htr1b | NP_034612.1 | 7tmA_5-HT1B_1D | 42..376 | CDD:320455 | 131/581 (23%) |
| TM helix 1 | 47..73 | CDD:320455 | 3/25 (12%) | ||
| TM helix 2 | 80..106 | CDD:320455 | 11/25 (44%) | ||
| TM helix 3 | 118..148 | CDD:320455 | 17/29 (59%) | ||
| Agonist binding. /evidence=ECO:0000250 | 121..130 | 1/8 (13%) | |||
| DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 142..144 | 1/1 (100%) | |||
| TM helix 4 | 160..183 | CDD:320455 | 11/23 (48%) | ||
| TM helix 5 | 201..230 | CDD:320455 | 11/28 (39%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 255..278 | 11/78 (14%) | |||
| TM helix 6 | 303..333 | CDD:320455 | 15/29 (52%) | ||
| Agonist binding. /evidence=ECO:0000250 | 323..327 | 3/3 (100%) | |||
| TM helix 7 | 344..369 | CDD:320455 | 12/24 (50%) | ||
| NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 | 361..365 | 2/3 (67%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3253 |
| SonicParanoid | 1 | 1.000 | - | - | X366 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.940 | |||||