DRSC/TRiP Functional Genomics Resources

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Protein Alignment Octalpha2R and ADRA2C

DIOPT Version :9

Sequence 1:NP_001262715.1 Gene:Octalpha2R / 42258 FlyBaseID:FBgn0038653 Length:740 Species:Drosophila melanogaster
Sequence 2:NP_000674.2 Gene:ADRA2C / 152 HGNCID:283 Length:462 Species:Homo sapiens


Alignment Length:631 Identity:196/631 - (31%)
Similarity:271/631 - (42%) Gaps:196/631 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 AAGFYNQSSASGATSGNLTNPNHTEVHWD---GRYPSGYTLTHIVIASI--IVTILMIIIVVGNM 134
            ||...|.|.|....||.:.|.:...  |.   |:|.:|      .:|.:  :|..|::..||||:
Human    14 AAAGPNASGAGERGSGGVANASGAS--WGPPRGQYSAG------AVAGLAAVVGFLIVFTVVGNV 70

  Fly   135 LVIIAIATEKSLKNIQNWFIASLAVADFFLGLIIMPFSLANELMGYWIFGSWWCDIHSAMDVLLC 199
            ||:||:.|.::|:..||.|:.|||.||..:..::||||||||||.||.||..||.::.|:|||.|
Human    71 LVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFC 135

  Fly   200 TASIMNLCLISLDRYWSITKAVDYLKSRTPARAAVMITAVWIMSALICIPPLLGWKVKMPEG-PL 263
            |:||::||.||||||||:|:||:|...|||.|....|.|||::||:|..|||:. ..:.|:| ..
Human   136 TSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVS-LYRQPDGAAY 199

  Fly   264 PKCELSEDIGYVLYSALGSFYIPSCIMVFVYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTTAK 328
            |:|.|:::..|:|.|.:|||:.|..||..||.|||..||.|.|                   |..
Human   200 PQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTR-------------------TLS 245

  Fly   329 KGTIPMPSSSGVSALQLHQQRQIATIETPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQT 393
            :...|:                      .|:.||                .|:|.| |.|.|   
Human   246 EKRAPV----------------------GPDGAS----------------PTTENG-LGAAA--- 268

  Fly   394 VLAYANPNGAGTNSVTVVSSGNGGPGASGVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNSSI 458
                    |||.|       |:..|..:.|.|..       |:.|..|                 
Human   269 --------GAGEN-------GHCAPPPADVEPDE-------SSAAAER----------------- 294

  Fly   459 NVLNNNNGTVAMDGGATAAGGGNGSAVATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVSEF 523
               ....|.:.. ||...||...|:     ||....|         ||                 
Human   295 ---RRRRGALRR-GGRRRAGAEGGA-----GGADGQG---------AG----------------- 324

  Fly   524 DPSSSDSGVVSRCAVVKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQQQQ 588
             |.:::||.::......|         .||.|....|..|...:.:.:..|.|.           
Human   325 -PGAAESGALTASRSPGP---------GGRLSRASSRSVEFFLSRRRRARSSVC----------- 368

  Fly   589 QQQVVKSELEPAIPKTPKPRDPEKEKRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILVPAC 653
                                     :|::|:.:|||.|.:|.::||.|:.||.||||.|.|...|
Human   369 -------------------------RRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGIC 408

  Fly   654 SSHCNIPESAFAVAFWLGYMNSALNPAIYTIFNKDFRRAFRRILFK 699
            ...|.:|...|...||:||.||:|||.|||:||:||||:|:.|||:
Human   409 REACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFR 454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Octalpha2RNP_001262715.1 7tm_1 132..>315 CDD:278431 91/183 (50%)
7tm_4 133..>252 CDD:304433 66/118 (56%)
ADRA2CNP_000674.2 7tmA_alpha2C_AR 60..448 CDD:320446 178/569 (31%)
TM helix 2 86..112 CDD:320446 14/25 (56%)
TM helix 3 124..154 CDD:320446 19/29 (66%)
TM helix 4 166..189 CDD:320446 11/22 (50%)
TM helix 5 207..236 CDD:320446 14/28 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..347 38/226 (17%)
TM helix 6 375..405 CDD:320446 15/29 (52%)
TM helix 7 416..441 CDD:320446 13/24 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 273 1.000 Domainoid score I1790
eggNOG 1 0.900 - - E33208_3BC1G
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 310 1.000 Inparanoid score I2603
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D323202at33208
OrthoFinder 1 1.000 - - FOG0001303
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR24248
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.970

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