DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Octalpha2R and ADRA2A

DIOPT Version :9

Sequence 1:NP_001262715.1 Gene:Octalpha2R / 42258 FlyBaseID:FBgn0038653 Length:740 Species:Drosophila melanogaster
Sequence 2:NP_000672.3 Gene:ADRA2A / 150 HGNCID:281 Length:465 Species:Homo sapiens


Alignment Length:631 Identity:190/631 - (30%)
Similarity:265/631 - (41%) Gaps:198/631 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 SSASGATSGNLTNPNHTEVHWDG-RYPSG----------YTLTHIVIASIIVTILMIIIVVGNML 135
            :..|.|..|:| .|:.....|:| ..|.|          .|||.:.:|.    :||::.|.||:|
Human     9 AEGSFAPMGSL-QPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAG----LLMLLTVFGNVL 68

  Fly   136 VIIAIATEKSLKNIQNWFIASLAVADFFLGLIIMPFSLANELMGYWIFGSWWCDIHSAMDVLLCT 200
            ||||:.|.::||..||.|:.|||.||..:..:::|||||||:||||.||..||:|:.|:|||.||
Human    69 VIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCT 133

  Fly   201 ASIMNLCLISLDRYWSITKAVDYLKSRTPARAAVMITAVWIMSALICIPPLLGWKVK----MPEG 261
            :||::||.||||||||||:|::|...|||.|...:|..||::||:|..|||:..:.|    .|:.
Human   134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQP 198

  Fly   262 PLPKCELSEDIGYVLYSALGSFYIPSCIMVFVYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTT 326
            ..|:||:::...||:.|.:|||:.|..||:.||:|||..||.|.|                    
Human   199 AEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTR-------------------- 243

  Fly   327 AKKGTIPMPSSSGVSALQLHQQRQIATIETPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAA 391
                 :| ||..|..|           :..||....                             
Human   244 -----VP-PSRRGPDA-----------VAAPPGGTE----------------------------- 262

  Fly   392 QTVLAYANPNGAGTNSVTVVSSGNGGPGASGVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNS 456
                  ..|||.|...    |:|.||..|..:|           |...|..|...|..|      
Human   263 ------RRPNGLGPER----SAGPGGAEAEPLP-----------TQLNGAPGEPAPAGP------ 300

  Fly   457 SINVLNNNNGTVAMDGGATAAGGGNGSAVATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVS 521
                    ..|.|:|   ......:..|...||..:...|...:     |:.||..| ...|.:.
Human   301 --------RDTDALD---LEESSSSDHAERPPGPRRPERGPRGK-----GKARASQV-KPGDSLP 348

  Fly   522 EFDPSSSDSGVVSRCAVVKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQQ 586
            ...|.::..|                                ..||...::..|.|..::.:.:|
Human   349 RRGPGATGIG--------------------------------TPAAGPGEERVGAAKASRWRGRQ 381

  Fly   587 QQQQQVVKSELEPAIPKTPKPRDPEKEKRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILVP 651
                                             .:|||.|.:|.:::|.|:.||.||||.|.|. 
Human   382 ---------------------------------NREKRFTFVLAVVIGVFVVCWFPFFFTYTLT- 412

  Fly   652 ACSSHCNIPESAFAVAFWLGYMNSALNPAIYTIFNKDFRRAFRRIL 697
              :..|::|.:.|...||.||.||:|||.||||||.||||||::||
Human   413 --AVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKIL 456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Octalpha2RNP_001262715.1 7tm_1 132..>315 CDD:278431 92/186 (49%)
7tm_4 133..>252 CDD:304433 67/118 (57%)
ADRA2ANP_000672.3 7tmA_alpha2A_AR 49..452 CDD:320445 176/584 (30%)
TM helix 1 51..75 CDD:320445 11/27 (41%)
TM helix 2 84..106 CDD:320445 9/21 (43%)
TM helix 3 122..144 CDD:320445 12/21 (57%)
TM helix 4 167..183 CDD:320445 6/15 (40%)
TM helix 5 209..232 CDD:320445 10/22 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..368 39/267 (15%)
PHA03307 244..>389 CDD:223039 44/294 (15%)
TM helix 6 388..410 CDD:320445 10/21 (48%)
TM helix 7 420..445 CDD:320445 14/24 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 273 1.000 Domainoid score I1790
eggNOG 1 0.900 - - E33208_3BC1G
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H47944
Inparanoid 1 1.050 310 1.000 Inparanoid score I2603
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D323202at33208
OrthoFinder 1 1.000 - - FOG0001303
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24248
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3253
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
99.000

Return to query results.
Submit another query.