DRSC/TRiP Functional Genomics Resources

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Protein Alignment Octalpha2R and htr1b

DIOPT Version :10

Sequence 1:NP_001262715.1 Gene:Octalpha2R / 42258 FlyBaseID:FBgn0038653 Length:740 Species:Drosophila melanogaster
Sequence 2:XP_002936251.2 Gene:htr1b / 100495915 XenbaseID:XB-GENE-988006 Length:385 Species:Xenopus tropicalis


Alignment Length:618 Identity:144/618 - (23%)
Similarity:228/618 - (36%) Gaps:262/618 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 NPNHTEVHWDGR--------YPSGYTLTHI-VIASIIVTILMIIIVVGNMLVIIAIATEKSLKNI 149
            |.:.|...:|||        |.....|:.. :|.::|:.::.:..::.|..||..:...:.|...
 Frog    15 NVSQTNYSFDGRSCITSLDSYGQEDVLSFSKIILTVILALITLATLLSNAFVITTVYQTRKLHTP 79

  Fly   150 QNWFIASLAVADFFLGLIIMPFSLANELMGYWIFGSWWCDIHSAMDVLLCTASIMNLCLISLDRY 214
            .|:.|||||..|..:.::::|.::...:.|.|..|...||:..:.|:..|||||::||:|:||||
 Frog    80 ANYLIASLAFTDLLVSILVLPIAIVYTVTGKWTLGQIICDMWLSSDITCCTASILHLCVIALDRY 144

  Fly   215 WSITKAVDYLKSRTPARAAVMITAVWIMSALICIPPLLGWKVKMPEGPLPKCELSED-IGYVLYS 278
            |:||.||:|.|.|||.||.|||..||:.|..|.:|||. |:....| .:..|.::.| |.|.:||
 Frog   145 WAITDAVEYTKKRTPKRAVVMIALVWVFSISISMPPLF-WRQSKAE-EIAVCAVNTDHILYTVYS 207

  Fly   279 ALGSFYIPSCIMVFVYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTTAKKGTIPMPSSSGVSAL 343
            .:|:||||:.:::.:|.|||..|::|.   :|:.|:          ||.|:.|            
 Frog   208 TVGAFYIPTLLLIALYGRIYVEARSRI---LKQSPK----------TTGKRLT------------ 247

  Fly   344 QLHQQRQIATIETPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYANPNGAGTNSV 408
            :.|      .|...|.|:|:                                       :.|||.
 Frog   248 KAH------LITDSPGSSSV---------------------------------------SSTNSR 267

  Fly   409 TVVSSGNGGPGASGVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNNNGTVAMDGG 473
            |                                  |.:|                          
 Frog   268 T----------------------------------LEMP-------------------------- 272

  Fly   474 ATAAGGGNGSAVATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVSEFDPSSSDSGVVSRCAV 538
                                                                  ||:|       
 Frog   273 ------------------------------------------------------SDAG------- 276

  Fly   539 VKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQQQQQQQVVKSELEPAIPK 603
                     .|::         .|:.|.                                     
 Frog   277 ---------SPVY---------LNQVKV------------------------------------- 286

  Fly   604 TPKPRDPEKEKRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILVPACSSHCNIPESAFAVAF 668
              |..|...||::|...:|::||..||:|:|::|.||||||.:.:::|.|...|....:.|....
 Frog   287 --KVSDALLEKKKIMAARERKATKTLGVILGAYIVCWLPFFIISLVMPICKDACWFHPAIFDFFN 349

  Fly   669 WLGYMNSALNPAIYTIFNKDFRRAFRRIL--FK 699
            ||||:||.:||.|||:.|:||::||.:::  ||
 Frog   350 WLGYLNSLINPIIYTMSNEDFKQAFHKLINRFK 382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Octalpha2RNP_001262715.1 7tmA_alpha2_AR 132..>307 CDD:320187 71/175 (41%)
TM helix 2 150..176 CDD:320187 8/25 (32%)
TM helix 3 188..218 CDD:320187 16/29 (55%)
TM helix 4 230..253 CDD:320187 12/22 (55%)
TM helix 5 271..300 CDD:320187 14/29 (48%)
7tm_GPCRs <616..693 CDD:475119 33/76 (43%)
TM helix 6 626..648 CDD:410628 12/21 (57%)
TM helix 7 661..686 CDD:410628 12/24 (50%)
htr1bXP_002936251.2 7tmA_5-HT1B_1D 42..374 CDD:320455 133/581 (23%)
TM helix 1 47..73 CDD:320455 5/25 (20%)
TM helix 2 80..106 CDD:320455 8/25 (32%)
TM helix 3 118..148 CDD:320455 16/29 (55%)
TM helix 4 160..183 CDD:320455 12/23 (52%)
TM helix 5 200..229 CDD:320455 13/28 (46%)
TM helix 6 301..331 CDD:320455 14/29 (48%)
TM helix 7 342..367 CDD:320455 12/24 (50%)

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