Protein Alignment Octalpha2R and taar3

DIOPT Version :10

• Sequence 1: NP_001262715.1
• Gene: Octalpha2R / 42258
• FlyBaseID: FBgn0038653
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: XP_004914927.3
• Gene: taar3 / 100488107
• XenbaseID: XB-GENE-1011223
• Length: 335
• Species: Xenopus tropicalis
• Alignment Length: 602
• Identity: 115/602 - (19%)
• Similarity: 173/602 - (28%)
• Gaps: 310/602 - (51%)

  Fly   105 RYPSGYTLTHIVIASIIVTILMIIIVVGNMLVIIAIATEKSLKNIQNWFIASLAVADFFLGLIIM 169
            |.|:.|::..||:...|     |:..:||::|||:::..|.|.:..|:.|.||||.||.|||:||
 Frog    17 RSPASYSVMIIVMLGAI-----ILTTIGNLMVIISVSHFKQLHSPTNFLILSLAVTDFLLGLVIM 76

  Fly   170 PFSLANELMGYWIFGSWWCDIHSAMDVLLCTASIMNLCLISLDRYWSITKAVDYLKSRTPARAAV 234
            |:|:...|...|.||..:|.:|..:|:.|.|:||.:|..||:|||:::.:.:.|.|..|.....|
 Frog    77 PYSMVRSLTSCWYFGDLFCKLHGCIDMALSTSSIFHLFFISVDRYYAVCQPLHYYKCITNNVIQV 141

  Fly   235 MITAVWIMSALICIPPLLGWKVKMPEG---------PLPKCELSEDIGYVLYSALGSFYIPSCIM 290
            .:...|.:|.|....  |.:.....||         ....|.|:.:..:...|||.||:||..:|
 Frog   142 FLFISWSVSCLYSFG--LVFSNIHTEGIQHYIASFTCTGSCSLAFNKIWGAISALISFFIPGTLM 204

  Fly   291 VFVYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTTAKKGTIPMPSSSGVSALQLHQQRQIATIE 355
            :.:||.|:..|..:|     ||....:|
 Frog   205 IGIYIHIFSVANKQA-----KHMHNHHN------------------------------------- 227

  Fly   356 TPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYANPNGAGTNSVTVVSSGNGGPGA 420
                                                                             
 Frog   228 ----------------------------------------------------------------- 227

  Fly   421 SGVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNNNGTVAMDGGATAAGGGNGSAV 485
              :.|..|...::||.
 Frog   228 --IQPDRPSIQIKVSV------------------------------------------------- 241

  Fly   486 ATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVSEFDPSSSDSGVVSRCAVVKPLKFRLCQPI 550
                                                                             
 Frog   242 ----------------------------------------------------------------- 241

  Fly   551 FGRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQQQQQQQVVKSELEPAIPKTPKPRDPEKEKR 615
                      |.|:|||                                   ||
 Frog   242 ----------RAESKAA-----------------------------------KT----------- 250

  Fly   616 RIARKKEKRATLILGLIMGSFIACWLPFFFLYILVPACSSHCNIPESAFAVAFWLGYMNSALNPA 680
                         |.::||.|:.||||||.|.|:.|..  :.:..|..::...||||.||||||.
 Frog   251 -------------LSIVMGVFLFCWLPFFILTIVDPYI--NFSTSEHVYSTVLWLGYFNSALNPI 300

  Fly   681 IYTIFNKDFRRAFRRIL 697
            ||.:|...|::.|:.|:
 Frog   301 IYALFYPWFQKTFQFII 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octalpha2R	NP_001262715.1	7tmA_alpha2_AR	132..>307	CDD:320187	64/183 (35%)
		TM helix 2	150..176	CDD:320187	15/25 (60%)
		TM helix 3	188..218	CDD:320187	13/29 (45%)
		TM helix 4	230..253	CDD:320187	4/22 (18%)
		TM helix 5	271..300	CDD:320187	11/28 (39%)
		7tm_GPCRs	<616..693	CDD:475119	28/76 (37%)
		TM helix 6	626..648	CDD:410628	11/21 (52%)
		TM helix 7	661..686	CDD:410628	13/24 (54%)
taar3	XP_004914927.3	7tmA_TAAR2_3_4	23..313	CDD:320437	110/590 (19%)
		TM helix 1	24..50	CDD:320437	9/30 (30%)
		TM helix 2	57..83	CDD:320437	15/25 (60%)
		TM helix 3	95..125	CDD:320437	13/29 (45%)
		TM helix 4	137..160	CDD:320437	5/24 (21%)
		TM helix 5	185..214	CDD:320437	11/28 (39%)
		TM helix 6	242..272	CDD:320437	19/88 (22%)
		TM helix 7	281..306	CDD:320437	13/24 (54%)