DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octalpha2R and adra2b

DIOPT Version :9

Sequence 1:	NP_001262715.1	Gene:	Octalpha2R / 42258	FlyBaseID:	FBgn0038653	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_002932610.1	Gene:	adra2b / 100485811	XenbaseID:	XB-GENE-999343	Length:	410	Species:	Xenopus tropicalis

Alignment Length:	601	Identity:	176/601 - (29%)
Similarity:	251/601 - (41%)	Gaps:	213/601 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 PSGYTLTHIVIASIIVTILMIIIVVGNMLVIIAIATEKSLKNIQNWFIASLAVADFFLGLIIMPF 171
            |..|::....:.:.|:|.|::..:.||:|||||:.|.:|||..||.|:.|||.||..:..:|:||
Frog     4 PLSYSIQATAVIAAIITFLVLFTIFGNVLVIIAVLTSRSLKAPQNLFLVSLAAADILVATLIIPF 68

  Fly   172 SLANELMGYWIFGSWWCDIHSAMDVLLCTASIMNLCLISLDRYWSITKAVDYLKSRTPARAAVMI 236
            ||||||||||.||..||:::.|:|||.||:||::||.||||||||:::|::|...|||.|...:|
Frog    69 SLANELMGYWYFGKTWCEMYLALDVLFCTSSIVHLCAISLDRYWSVSQAIEYNSKRTPKRIKCII 133

  Fly   237 TAVWIMSALICIPPLLGWKVKMPEGPLPKCELSEDIGYVLYSALGSFYIPSCIMVFVYIRIYFAA 301
            ..||.::|||.:|||:.......:...|:|:|:|:..|:|.|::.||:.|..||:.||:|||..|
Frog   134 LIVWTLAALISLPPLIYKGKSKDQNAKPECKLNEEPWYILSSSICSFFAPCLIMILVYLRIYLIA 198

  Fly   302 KARARRG-----IKKHP----RKTNNEQV-TSFTTAKKGTIPMPSSSGVSALQLHQQRQIATIET 356
            |.|.|:.     :||..    .:||...: :|.|..:.|.|.....:|::...||
Frog   199 KRRNRKNSTDKKLKKMAPGLFSRTNKHSLNSSHTQTQCGIISSQEKTGLALDDLH---------- 253

  Fly   357 PPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYANPNGAGTNSVTVVSSGNGGPGAS 421
                    ..:|.::       ||.|                              ..||...:.
Frog   254 --------CGVPVLS-------STRE------------------------------ERNGHSESF 273

  Fly   422 GVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNNNGTVAMDGGATAAGGGNGSAVA 486
            |:.|                          .|.|     |.:.||
Frog   274 GLQP--------------------------QGEN-----LKHTNG-------------------- 287

  Fly   487 TPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVSEFDPSSSDSGVVSRCAVVKPLKFRLCQPIF 551
                                 |                    :..|:...|.||
Frog   288 ---------------------C--------------------EPAVMDTVATVK----------- 300

  Fly   552 GRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQQQQQQQVVKSELEPAIPKTPKPRDPEKEKRR 616
                                   ||.                      .:||..|..|....|::
Frog   301 -----------------------GVM----------------------LMPKGAKDSDLSSAKKK 320

  Fly   617 IARKKEKRATLILGLIMGSFIACWLPFFFLYILVPACSSHCNIPESAFAVAFWLGYMNSALNPAI 681
            ....:|||.|.:|.:::|.|:.||.||||.|.|...|:..|.||:|.|...||:||.||:|||.|
Frog   321 SYINREKRFTFVLAVVIGVFVLCWFPFFFTYSLGAICTELCYIPDSVFQFFFWIGYCNSSLNPVI 385

  Fly   682 YTIFNKDFRRAFRRIL 697
            |||||:|||:||||||
Frog   386 YTIFNQDFRKAFRRIL 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octalpha2R	NP_001262715.1	7tm_1	132..>315	CDD:278431	92/191 (48%)
Octalpha2R	NP_001262715.1	7tm_4	133..>252	CDD:304433	67/118 (57%)
adra2b	XP_002932610.1	7tm_4	20..>152	CDD:304433	71/131 (54%)
adra2b	XP_002932610.1	7tm_1	29..386	CDD:278431	156/559 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I1441
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	333	1.000	Inparanoid score	I2375
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323202at33208
OrthoFinder	1	1.000	-	-		FOG0001303
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.070