DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7720 and SLC5A2

DIOPT Version :9

Sequence 1:	NP_001163649.1	Gene:	CG7720 / 42257	FlyBaseID:	FBgn0038652	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_006721135.2	Gene:	SLC5A2 / 6524	HGNCID:	11037	Length:	705	Species:	Homo sapiens

Alignment Length:	700	Identity:	138/700 - (19%)
Similarity:	246/700 - (35%)	Gaps:	183/700 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DYLMFVLFIALTVLGPLWKRIFGKKKERSKADYVFATG--------GVSIVAVMISIAR--GTLG 65
            |.|:...:..|.:...||...   :..|......|..|        |.|:.|..|....  |..|
Human    32 DILVIAAYFLLVIGVGLWSMC---RTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAG 93

  Fly    66 VRSVLGYPSELYYRGSAMWEIIYGMMSAYPIVCFMFVPVYFNLGITSVYQYIDLRFKSRTVRCLA 130
            .    |..|.|...|.. |..::.::    ::.::|.|||...|:.::.||:..||..|.:|...
Human    94 T----GAASGLAVAGFE-WNALFVVL----LLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYL 149

  Fly   131 SA----TYIVRQICNLGITVYTPSVALSTVIGIPYWASITGMAVICIFFTIMGGLKAAINADVIQ 191
            |.    .||..:|   .:.:::.:|.:...:|...:||:..:..|.:.:|:.|||.|.:..|.:|
Human   150 SVLSLFLYIFTKI---SVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQ 211

  Fly   192 TVTILVVTVAVCI------------QG------------TIS----TGGVKK-VYQLNRDNGRLN 227
            |..||   ...||            .|            |:|    .|.:.. .|:...|:..|.
Human   212 TFVIL---GGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLL 273

  Fly   228 FWNFTGDMTVRVDTTSAW----LGQLFMSLSQIGCQQNFMQRYVSLKSLKQVRR--VMLTNVPLV 286
            ....|||:        .|    ||...:|.......|..:||.::.|||..::.  ::...:.|.
Human   274 RHPVTGDL--------PWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLT 330

  Fly   287 FFFFSISWISGMV-------------------IYSTYINCDPYAEGYIKKPDEILPFFVEDQLGF 332
            ..|..:  :.||:                   :..|.:.|...|  |.:...:::|
Human   331 PMFLMV--MPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIA--YPRLVVKLMP--------- 382

  Fly   333 LPGFVGIFMATLFNGALCMMVSNLNSLATVIWEDFISQLPKFKGLSDKQQLRILKSITVVCGLII 397
             .|..|:.:|.:....:..:.|..||.:|:...|..::|....|   .::|.::..:.||. :::
Human   383 -NGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAG---DRELLLVGRLWVVF-IVV 442

  Fly   398 MGVAF--------GVGLLAGVIESSLLVFSATSGPLLGCFILAMMVPIANWKGTSAGMVTACAFV 454
            :.||:        | |.|...|::   |.|..:.|:...|:||:.||..|.:|...|::
Human   443 VSVAWLPVVQAAQG-GQLFDYIQA---VSSYLAPPVSAVFVLALFVPRVNEQGAFWGLI------ 497

  Fly   455 LWIIGGG--MTVTKDNPLLPTSTDGCTNDTFAQSIGKPIVEQGQMPWLLSHTPIDGFNQSFVPTQ 517
                 ||  |.:.:..|.....:..|                                     .|
Human   498 -----GGLLMGLARLIPEFSFGSGSC-------------------------------------VQ 520

  Fly   518 PTIAPERSGLETFYSISFMYYSLIGTALTVIIGTVISLLTQHPDDAYDGKLLHPLIFRLCERFSG 582
            |:..|     .....:.::|::::....:.::...:||.|.    ....|.||.|:|.|......
Human   521 PSACP-----AFLCGVHYLYFAIVLFFCSGLLTLTVSLCTA----PIPRKHLHRLVFSLRHSKEE 576

  Fly   583 RKPYYVKHEEESGLNGRSSSDSSATTTTCKAEKVNHGYESSPEDKEKSSP 632
            |:......::.|.|..::....||.....:|.....|.|.....|..:.|
Human   577 REDLDADEQQGSSLPVQNGCPESAMEMNGRAPCWEVGLEELSSRKLTAGP 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7720	NP_001163649.1	SLC5sbd_NIS-SMVT	10..556	CDD:271383	120/622 (19%)
SLC5A2	XP_006721135.2	SLC5sbd_SGLT2	31..705	CDD:212056	137/699 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810