Protein Alignment CG7720 and SLC5A1

DIOPT Version :9

• Sequence 1: NP_001163649.1
• Gene: CG7720 / 42257
• FlyBaseID: FBgn0038652
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_000334.1
• Gene: SLC5A1 / 6523
• HGNCID: 11036
• Length: 664
• Species: Homo sapiens
• Alignment Length: 727
• Identity: 137/727 - (18%)
• Similarity: 274/727 - (37%)
• Gaps: 201/727 - (27%)

  Fly     2 AKDLSTMGWDYLMFVLFIALTVLGPLWKRIFGKKKERSKADYVFATGGVSIVAVMISIARGTLG- 65
            |.|:|      ::.:.|:.:..:| ||                          .|.|..|||:|
Human    26 AADIS------IIVIYFVVVMAVG-LW--------------------------AMFSTNRGTVGG 57

  Fly    66 ----VRSVLGYP--SELY-----------------YRGSAMWEIIYGMMSAYPIVCFMFVPVYFN 107
                .||::.:|  :.|:                 ..|.|:....:..:....::.::|||:|..
Human    58 FFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIK 122

  Fly   108 LGITSVYQYIDLRFKSRTVRCLASATYIVRQI-CNLGITVYTPSVALSTVIGIPYWASITGMAVI 171
            .|:.::.:|:..||..:.::...|...::..| ..:...:::.::.::..:|:..:.:|..:..|
Human   123 AGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAI 187

  Fly   172 CIFFTIMGGLKAAINADVIQTVTILVVTVAV--------------------CIQGTISTGGV--- 213
            ...:||.|||.|.|..|.:|||.:||.::.:                    .|...:|.|..
Human   188 TALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQ 252

  Fly   214 KKVYQLNRDNGRLNFWNFTGDMTVRVDTTSAWLGQLF-MSLSQI--GC-QQNFMQRYVSLKSLKQ 274
            :|.|....|:..:.....|||:        .|.|.:| ||:..:  .| .|..:||.:|.|::..
Human   253 EKCYTPRADSFHIFRDPLTGDL--------PWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSH 309

  Fly   275 VRR--VMLTNVPLVFFFFSISWISGM---VIYSTYI------NCDPYAEGYIKKPDEILPFFVED 328
            |:.  ::...:.|:..|..:  :.||   ::|:..|      .|:.|....:...:...|..|.:
Human   310 VKGGCILCGYLKLMPMFIMV--MPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVE 372

  Fly   329 QLGFLP-GFVGIFMATLFNGALCMMVSNLNSLATVIWEDFISQLPKFKGLSDKQQLRILKSITVV 392
               .:| |..|:.::.:....:..:.|..||.:|:...|..:::.|   .:.:::|.|...:.:
Human   373 ---LMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRK---RASEKELMIAGRLFI- 430

  Fly   393 CGLIIMGVAFG---------VGLLAGVIESSLLVFSATSGPLLGCFILAMMVPIANWKGTSAGMV 448
              |:::|::..         .|.|...|:|   :.|....|:...|:||:.....|..|...|::
Human   431 --LVLIGISIAWVPIVQSAQSGQLFDYIQS---ITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLI 490

  Fly   449 TACAFVLWIIGGGMTVTKDNPLLPTSTDGCTNDTFAQSIGKPIVEQGQMPWLLSHTPIDGFNQSF 513
            ...     :||....:|:                ||...|. .:|....|.::.
Human   491 LGL-----LIGISRMITE----------------FAYGTGS-CMEPSNCPTIIC----------- 522

  Fly   514 VPTQPTIAPERSGLETFYSISFMYYSLIGTALTVIIGTVISLLTQHPDDAYDGKLLHPLIFRLC- 577
                              .:.::|:::|..|::.|...||||||:...|.:        ::|||
Human   523 ------------------GVHYLYFAIILFAISFITIVVISLLTKPIPDVH--------LYRLCW 561

  Fly   578 -ERFSGRKPYYVKHEEESGLNGRSSSDSSATTTTCKAEKV------------NHGYESSPEDKEK 629
             .|.|..:...:..|||:...|...:....|....|.:.:            .||.....|::||
Human   562 SLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEK 626

  Fly   630 SSPIAVVFTTSE 641
            :..:.:..|:.:
Human   627 AMKMKMTDTSEK 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7720	NP_001163649.1	SLC5sbd_NIS-SMVT	10..556	CDD:271383	113/618 (18%)
SLC5A1	NP_000334.1	SLC5sbd_SGLT1	27..664	CDD:271379	136/726 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810