DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7720 and slc5a3b

DIOPT Version :9

Sequence 1:	NP_001163649.1	Gene:	CG7720 / 42257	FlyBaseID:	FBgn0038652	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_005167848.1	Gene:	slc5a3b / 568338	ZFINID:	ZDB-GENE-070912-43	Length:	709	Species:	Danio rerio

Alignment Length:	743	Identity:	146/743 - (19%)
Similarity:	265/743 - (35%)	Gaps:	187/743 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AKDLSTMGWDYLMFVLFIALTVLGPLWKRIFGKKKERSKADYVFATGGVSIVAVMISIARGTLGV 66
            |.|::.:.   |.|||.:.:.:|. :|     |....:.:.|..|...::...:..|:....:|.
Zfish    10 AADITVVA---LYFVLVLVIGLLA-MW-----KANHSTVSGYFLAGRTMNWAVIGASLFVSNIGS 65

  Fly    67 RSVLGYPSELYYRGSAM--WEIIYGMMSAYPIVCFMFVPVYFNLGITSVYQYIDLRFKSRTVRC- 128
            ...:|........|.|:  ||  :..:....::.::|:|||.:.|:.::.:|:..|:..:.::.
Zfish    66 EHFIGLAGSGAASGFAVAAWE--FNALLLLQLLGWVFIPVYIHSGVYTMPEYLSKRYGGKRLKIY 128

  Fly   129 LASATYIVRQICNLGITVYTPSVALSTVIGIPYWASITGMAVICIFFTIMGGLKAAINADVIQTV 193
            .|..:.::.....|.:.:|..::.:...:|...:.||..:..:....|:.|||.|.|..|.:|.|
Zfish   129 FAGLSLLLYIFTKLSVDLYAGALFIQESLGWNLYLSIILLISMTALLTVTGGLVAVIYTDTLQAV 193

  Fly   194 TILVVTVAVCIQGTISTGGVKKVYQLNRD-----NGRLNFWNFTGDMT--------------VR- 238
            .::...:.:.|...|..||::.|.:...:     ...|...||:.:.|              :|
Zfish   194 LMIGGALTLTIISLIKVGGLEGVREKYMEAVPNVTAILASSNFSFEYTNSCRIYPKPDSLKLLRG 258

  Fly   239 -VDTTSAW----LGQLFMSLSQIGCQQNFMQRYVSLKSLKQVR-RVMLTNVPLVFFFFSISWISG 297
             :|....|    |||...|:......|..:||.::.|::...: ..::..|..:...|.|. |.|
Zfish   259 PLDEDIPWPGFLLGQTPSSIWYWCADQVIVQRVLAAKNIAHAKGSTLMAGVLKILPMFIIV-IPG 322

  Fly   298 MVIYSTYINCDPYAEGYIKKPDEI----------------------LPFFVEDQLGFLP-GFVGI 339
            |:             ..|..|||:                      .|..|   :..:| |..|:
Zfish   323 MI-------------SRILFPDELACIGPEHCMAVCGSQAGCSNIAYPRLV---MSVMPVGLRGL 371

  Fly   340 FMATLFNGALCMMVSNLNSLATVIWEDFISQLPKFKGLSDKQQLRILKSITVVCGLIIMGVAFGV 404
            .||.:....:..:.|..||.:|:...|....|   :..:..::|.::..|     .:|..||..:
Zfish   372 MMAVMIAALMSDLDSIFNSASTIFTLDIYKML---RARASSRELVVIGRI-----FVIFMVAISI 428

  Fly   405 GLLAGVIE----SSLLVFSATSG----PLLGCFILAMMVPIANWKGTSAGMVTACAFVLWIIG-- 459
            ..:..:||    ...|.....:|    |:...|:|.:.     ||..:.            ||
Zfish   429 AWVPVIIEMQGGQMYLYIQEVAGYLTPPIAALFLLGVF-----WKRCNE------------IGAF 476

  Fly   460 -GGMTVTKDNPLLPTSTDGCTNDTFAQSIGKPIVEQGQMPWLLSHTPIDGFNQSFVPTQPTI--A 521
             ||||             |....|....:|                        |:..:|..  .
Zfish   477 CGGMT-------------GFVLGTTRLLLG------------------------FIYREPKCDQP 504

  Fly   522 PERSGLETFYSISFMYYSLIGTALTVIIGTVISLLTQHPDD-------AYDGKLLHPLIFRLCER 579
            .||....|  .|.:||.:.....::.::..|:||.|..||:       .:..:.|..|:
Zfish   505 DERPAFIT--RIHYMYIAAGLFWISGLVAVVVSLCTTPPDEERIKRTTMWGLRKLRRLV------ 561

  Fly   580 FSGRKPYYVKHEEESGLNGRSSSDSSATTTTCKAEKVNHGYE-----SSPEDKEKSSPIAVVFTT 639
            .:.|:..| |....|| ||....|   .....:.||...|.:     .||.|::.::|.....|.
Zfish   562 VTEREEMY-KLTNGSG-NGILKKD---VPEDVQKEKCLDGADIKLLLPSPCDQDPTTPNTEASTP 621

  Fly   640 SE--GTGSA-----GDQQSICDSSRIQL 660
            .|  |.|.|     .|:....|.|.:|:
Zfish   622 MELYGNGHAKLVKQKDESQSDDESCLQV 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7720	NP_001163649.1	SLC5sbd_NIS-SMVT	10..556	CDD:271383	114/610 (19%)
slc5a3b	XP_005167848.1	SLC5-6-like_sbd	12..709	CDD:294310	145/741 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910