DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7720 and CG2187

DIOPT Version :9

Sequence 1:	NP_001163649.1	Gene:	CG7720 / 42257	FlyBaseID:	FBgn0038652	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	645	Identity:	177/645 - (27%)
Similarity:	310/645 - (48%)	Gaps:	77/645 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DYLMFVLFIALTVLGPLWKRIFGKKKERSKADYVFATGGVSIVAVMISIARGTLGVRSVLGYPSE 75
            ||.:||:.:..:....::...|.|.|..:: :|:.....:..:.:.||:....|...:::..|:|
  Fly    28 DYFVFVIMLGASAGIGVYFGFFSKSKNTTE-EYLRGGKKMQTLPIAISLVASQLSGIAIMSIPAE 91

  Fly    76 LYYRGSAMWEIIYGMMSAYPIVCFMFVPVYFNLGITSVYQYIDLRFKSRTVRCLASATYIVRQIC 140
            .|..|.....::..|:...||:.::.|||::...:::.|:|:::||..|| |.|.:..::.....
  Fly    92 SYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRT-RQLVTFFFVTNSFL 155

  Fly   141 NLGITVYTPSVALSTVIGIPYWASITGMAV---------ICIFFTIMGGLKAAINADVIQTVTIL 196
            .|.:.::.||:|         :|.:|||.:         ||||:|::||:||.:..||:|...:|
  Fly   156 MLPVYMFIPSLA---------FAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIML 211

  Fly   197 VVTVAVCIQGTISTGGVKKVYQLNRDNGRLNFWNFTGDMTVRVDTTSAWLGQLFMSLSQIGCQQN 261
            :..|||.:.|||.:||:..|.:...|.||.|| :|..|..:|:....|.:|.:||....||..|:
  Fly   212 LSVVAVGVLGTIRSGGMFTVMERASDGGRFNF-DFGLDPRIRMTFWGATMGGIFMWTGHIGLNQS 275

  Fly   262 FMQRYVSLKSLKQVRRVMLTNVP--LVFFFFSISWISGMVIYSTYINCDPYAEGYIKKPDEILPF 324
            .:||.|||.|....::.::.:..  |:..||:.  |||:::::.|..|||...|.:.|||:::||
  Fly   276 CVQRIVSLPSYSHAKKSLIVSGLGFLIISFFNT--ISGIIMFARYYGCDPMLAGLVSKPDKMMPF 338

  Fly   325 FVEDQLGFLPGFVGIFMATLFNGALCMMVSNLNSLATVIWEDFISQLPKFKGLSDKQQLRILKSI 389
            ||:|.:|.|.|..|:|::.:|:.||..:.:.|||||.|::.|:|.  |:.:....:....:...:
  Fly   339 FVQDIMGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFDYIK--PRIRHTEARANWAMKLIV 401

  Fly   390 TVVCGLIIMGVAFGVGLLAGVIESSLLVFSATSGPLLGCFILAMMVPIANWKGTSAGMVTACAFV 454
            .|:.|..|:| .|.|.....::::.:.:....:|.::|.|:|.|.||..|.|.....::.:...:
  Fly   402 VVMGGYCILG-GFMVQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAM 465

  Fly   455 LWIIGGGMTVTKDN----PLLPTSTDGCTND---TFAQSIGKPIVEQGQMPWLLSHTPIDGFNQS 512
            :|||..|....|..    .:||.|.|.|...   ..|::|.|           ...||:.....|
  Fly   466 VWIIANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINK-----------TDFTPVTMKPPS 519

  Fly   513 FVPTQPTIAPERSGLETFYSISFMYYSLIGTALTVIIGTVISLLTQHPD--DAYDGKLLHPLIFR 575
            ..|.......:|.  .:.|.|||.:|.::|:||..:....:|.:.: ||  :..:.||..|.:
  Fly   520 GAPVTTAFHSDRD--FSLYDISFYWYKVLGSALVFLCAIPLSYIWR-PDENEKQNPKLYSPFV-- 579

  Fly   576 LCERFSGRK----PYYVKHEEESGLNGRSSSDSSATTTTCKAEKVNHGYESSPEDKEKSS 631
                   ||    |...:..||..|.|    ...|.|...:.|         |.:|||.:
  Fly   580 -------RKFLSLPVTDQDLEEVPLRG----SKVAATPDLRIE---------PTEKEKQT 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7720	NP_001163649.1	SLC5sbd_NIS-SMVT	10..556	CDD:271383	158/562 (28%)
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	158/562 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I2508
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.970