DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7720 and slc5a2

DIOPT Version :9

Sequence 1:	NP_001163649.1	Gene:	CG7720 / 42257	FlyBaseID:	FBgn0038652	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_998091.1	Gene:	slc5a2 / 405862	ZFINID:	ZDB-GENE-040426-2498	Length:	662	Species:	Danio rerio

Alignment Length:	761	Identity:	150/761 - (19%)
Similarity:	275/761 - (36%)	Gaps:	207/761 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AKDLSTMGWDYLMFVLFIALTVLGPLWKRIFGKKKERSKADYVFATG--------GVSIVAVMIS 58
            |.|:|      ::.:.|:.:..:| :|...   :..|......|..|        |.|:.|..|.
Zfish    14 AADIS------VIIIYFLVVIAVG-IWSTF---RTNRGTVGGYFLAGRTMVWWPVGTSLFASNIG 68

  Fly    59 IAR--GTLGVRSVLGYPSELYYRGSAMWEIIYGMMSAYPIVCFMFVPVYFNLGITSVYQYIDLRF 121
            ...  |..|..:..|...     |...|..::.::    ::.::|||||...|:.::.||:..||
Zfish    69 SGHFVGLAGTAAASGIAV-----GGFEWNALFIVL----LLGWVFVPVYLTAGVITMPQYLKKRF 124

  Fly   122 -KSRTVRCLASATYIVRQICNLGITVYTPSVALSTVIGIPYWASITGMAVICIFFTIMGGLKAAI 185
             .||....|:..:..:.....:.:.:::.:|.:...:|...:.::..:..|...:|:.|||.|.:
Zfish   125 GGSRISLYLSIISLFLYIFTKISVDMFSGAVFIQQALGWNIYVAVIALLCITALYTVTGGLAALM 189

  Fly   186 NADVIQTVTILVVTVAVCIQGTISTGGVKKVYQLNRDNGRL---------NFWNF---------- 231
            ..|.:||..|:.....:........||...:  |.:.|..|         |.:|.
Zfish   190 YTDTVQTFVIIAGAFVLMGFSFYEVGGYSAL--LEKYNSSLPSQTLSLNPNEYNISQHCYMPRED 252

  Fly   232 ---------TGDMTVRVDTTSAWLGQLFMSLSQIG----C-QQNFMQRYVSLKSLKQVRR--VML 280
                     |||:        .|.|.:| .::.||    | .|..:||.::.:||..|:.  ::.
Zfish   253 AFHLLRDPTTGDL--------PWPGVIF-GIAIIGSWYWCTDQVIVQRCLAARSLTHVKAGCILC 308

  Fly   281 TNVPLVFFFFSISWISGMV-------------------IYSTYINCDPYAEGYIKKPDEILPFFV 326
            ..:.|:..|..:  ..||:                   :..|.:.|...|  |.|....::|
Zfish   309 GYLKLLPMFLMV--FPGMISRVLYPDDVGCVEKSVCNKVCGTEVGCSNIA--YPKLVVSVMP--- 366

  Fly   327 EDQLGFLPGFVGIFMATLFNGALCMMVSNLNSLATVIWEDFISQL-PKFKGLSDKQQLRILKSIT 390
                   .|..|:.:|.:....:..:.|..||.:|:...|..::: |:.:   || :|.::..:.
Zfish   367 -------TGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIWTRIRPQAR---DK-ELMVVGRVW 420

  Fly   391 VVCGLIIMGV---------AFGVGLLAGVIESSLLVFSATSGPLLGCFILAMMVPIANWKGTSAG 446
            ::|   |:|:         |...|.|...|:|   |.|..:.|:...|.||:.|...|..|
Zfish   421 ILC---IVGISTCWIPVVQAAQSGQLFDYIQS---VTSYLAPPIAAVFFLAIFVKRVNESG---- 475

  Fly   447 MVTACAFVLWIIGGG--MTVTKDNPLLPTSTDGCTNDTFAQSIGKPIVEQGQMPWLLSHTPIDGF 509
                 ||  |.:.||  |.:.:..|.....:..|.         ||           |:.|
Zfish   476 -----AF--WGLMGGLVMGLCRMVPEFVFGSGSCL---------KP-----------SNCP---- 509

  Fly   510 NQSFVPTQPTIAPERSGLETFYSISFMYYSLIGTALTVIIGTVISLLTQHPDDAYDGKLLHPLIF 574
                              :....:.::|::::....|.|:...:|..|....|    |.||.|:|
Zfish   510 ------------------KVICGVHYLYFAILLFFCTAILVLFVSYNTPPIKD----KHLHRLVF 552

  Fly   575 RLCERFSGRKPYYVK-HEEESGLNGRSSSDSSATTTTCKAEKVNHGYESSPEDKEKSSPIAVV-- 636
            .|  |.|..:...:. .|||.|...|..:|.       |....|.  |...|..|:|..:.::
Zfish   553 TL--RHSTEERVDLDWEEEERGRKARREADE-------KRRAKND--EDQIERGEQSIMMKIIGW 606

  Fly   637 -FTTSEGTGSAGDQQSICDSSRIQLDIVPGEGETGVYRQLAGRSAL 681
             ...|:.......::.:.::|: ||   |...|..:::.:...:||
Zfish   607 FCGISDTQAPEPTEEEVTEASK-QL---PDISENPLWKNIVNVNAL 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7720	NP_001163649.1	SLC5sbd_NIS-SMVT	10..556	CDD:271383	117/622 (19%)
slc5a2	NP_998091.1	SLC5sbd_SGLT2	15..662	CDD:212056	149/760 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910