DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7720 and Slc5a11

DIOPT Version :9

Sequence 1:	NP_001163649.1	Gene:	CG7720 / 42257	FlyBaseID:	FBgn0038652	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_666310.1	Gene:	Slc5a11 / 233836	MGIID:	1919316	Length:	673	Species:	Mus musculus

Alignment Length:	717	Identity:	146/717 - (20%)
Similarity:	260/717 - (36%)	Gaps:	202/717 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 YLMFVLFIALTVLGPLWKRIFGKKKERSKAD----YVFATG-------GVSIVAVMISIAR--GT 63
            |.:|||.:.      ||..:      |:|.|    |..|.|       |.|:.|..:....  |.
Mouse    35 YFLFVLAVG------LWSTV------RTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGL 87

  Fly    64 LGVRSVLGYPSELYYRGSAMWEIIYGMMSAYPIVCFMFVPVYFNLGITSVYQYIDLRFKSRTVRC 128
            .|..:.:|.....|.        :.|:.|.. ::.::|:|:|....:|::.:|:..||....:..
Mouse    88 AGSGAAVGISVAAYE--------LNGLFSVL-MLAWVFLPIYIAGQVTTMPEYLRRRFGGNRISI 143

  Fly   129 LASATYIVRQI-CNLGITVYTPSVALSTVIGIPYWASITGMAVICIFFTIMGGLKAAINADVIQT 192
            ..:..|:...| ..:.:.:|..::.:...:.:..:.:|.|:..|...:|:.|||.|.|..|.:||
Mouse   144 TLAVLYLFIYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITALYTVAGGLAAVIYTDALQT 208

  Fly   193 VTILVVTVAVCIQGTISTG---GVKKVYQL----NR-DNGRLN------FWNFTGDMTVRVDTTS 243
            |.:|:....:......:.|   |:|..|.|    || :|....      |..|...:|    :..
Mouse   209 VIMLIGAFILMGYSFAAVGGMEGLKDQYFLALASNRSENSSCGLPREDAFHIFRDPLT----SDL 269

  Fly   244 AWLGQLF-MSLSQI--GC-QQNFMQRYVSLKSLKQVR-----RVMLTNVPLVFFFFSISWISGMV 299
            .|.|.|| ||:..:  .| .|..:||.::.|:|...:     ...|..:||....|     .|||
Mouse   270 PWPGILFGMSIPSLWYWCTDQVIVQRSLAAKNLSHAKGGSLMAAYLKVLPLFLMVF-----PGMV 329

  Fly   300 -------------------IYSTYINCDPYAEGYIKKPDEILPFFVEDQLGFLPGFVGIFMATLF 345
                               :.|....|...|  |.|...|:||          .|..|:.||.:.
Mouse   330 SRVLFPDQVACAHPDICQRVCSNPSGCSDIA--YPKLVLELLP----------TGLRGLMMAVMV 382

  Fly   346 NGALCMMVSNLNSLATVIWEDFISQL-PKFKGLSDKQQLRILKSITVVCGLIIMGVAFGVGLLAG 409
            ...:..:.|..||.:|:...|..:.: |:    :.:::|.|:..| .|..|:::.:     |...
Mouse   383 AALMSSLTSIFNSASTIFTMDLWNHIRPR----ASERELMIVGRI-FVFALVLVSI-----LWIP 437

  Fly   410 VIESS----LLVF-----SATSGPLLGCFILAMMVPIANWKGTSAGMVTACAFVLWIIGGGMTVT 465
            ::::|    |.::     |....|:...||:.......|.||..:|:      :|.::.|.:.:.
Mouse   438 IVQASQGGQLFIYIQSISSYLQPPVAMVFIMGCFWKRTNEKGAFSGL------ILGLLLGLVRLI 496

  Fly   466 KDNPLLPTSTDGCTNDTFAQSIGKPIVEQGQMPWLLSHTPIDGFNQSFVPTQPTIAPERSGLETF 530
            .|             ..:||    |..:|          |.|         :|.:..:
Mouse   497 LD-------------FVYAQ----PRCDQ----------PDD---------RPAVVKD------- 518

  Fly   531 YSISFMYYSLIGTALTVIIGTVISLLTQHPDDAYDGKLL----H-------------PLIFRLCE 578
              :.::|:|:|.:..|:|....:|..|:.|......:|.    |             ||...|.:
Mouse   519 --VHYLYFSMILSFTTLITVVTVSWFTETPSKEMVSRLTWFTRHEPVAQKDSAPPETPLSLTLSQ 581

  Fly   579 RFSGRKP---YYVKHEEES-------GLNGRSSSDSSATTTTCKAEKVNHGYESSPEDKEKSSPI 633
            ..:...|   ..::..:||       |::.|.|....|....|..||      :..|...|:.|:
Mouse   582 NGTTEAPGTSIQLETVQESTTKACGDGVSPRHSKVVRAILWLCGMEK------NKEEPPSKAEPV 640

  Fly   634 AV 635
            .|
Mouse   641 IV 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7720	NP_001163649.1	SLC5sbd_NIS-SMVT	10..556	CDD:271383	125/609 (21%)
Slc5a11	NP_666310.1	SLC5-6-like_sbd	28..673	CDD:382020	146/717 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810