DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7720 and SLC5A11

DIOPT Version :9

Sequence 1:	NP_001163649.1	Gene:	CG7720 / 42257	FlyBaseID:	FBgn0038652	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001339171.1	Gene:	SLC5A11 / 115584	HGNCID:	23091	Length:	675	Species:	Homo sapiens

Alignment Length:	683	Identity:	139/683 - (20%)
Similarity:	258/683 - (37%)	Gaps:	167/683 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 YLMFVLFIALTVLGPLWKRIFGKKKERSKADYVFATG-------GVSIVAVMISIAR--GTLGVR 67
            |.:|||.:.      ||..:  |.|..:...|..|.|       |.|:.|..:....  |..|..
Human    35 YFLFVLAVG------LWSTV--KTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSG 91

  Fly    68 SVLGYPSELYYRGSAMWEIIYGMMSAYPIVCFMFVPVYFNLGITSVYQYIDLRFKSRTVRCLASA 132
            :..|.....|.        :.|:.|.. ::.::|:|:|....:|::.:|:..||....:..:.:.
Human    92 AATGISVSAYE--------LNGLFSVL-MLAWIFLPIYIAGQVTTMPEYLRKRFGGIRIPIILAV 147

  Fly   133 TYIVRQI-CNLGITVYTPSVALSTVIGIPYWASITGMAVICIFFTIMGGLKAAINADVIQTVTIL 196
            .|:...| ..:.:.:|..::.:...:.:..:.:|.|:..|...:|:.|||.|.|..|.:||:.:|
Human   148 LYLFIYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLIML 212

  Fly   197 VVTVAVCIQGTISTG---GVKKVYQL----NR-DNGRLN------FWNFTGDMTVRVDTTSAWLG 247
            :..:.:......:.|   |:|:.|.|    || :|....      |..|...:|    :...|.|
Human   213 IGALTLMGYSFAAVGGMEGLKEKYFLALASNRSENSSCGLPREDAFHIFRDPLT----SDLPWPG 273

  Fly   248 QLF-MSLSQI--GC-QQNFMQRYVSLKSLKQVR-----RVMLTNVPLVFFFFSISWISGMV---I 300
            .|| ||:..:  .| .|..:||.::.|:|...:     ...|..:||....|     .|||   :
Human   274 VLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIMVF-----PGMVSRIL 333

  Fly   301 YSTYINC-DP-YAEGYIKKP----DEILPFFVEDQLGFLP-GFVGIFMATLFNGALCMMVSNLNS 358
            :...:.| || ..:.....|    |...|..|   |..|| |..|:.||.:....:..:.|..||
Human   334 FPDQVACADPEICQKICSNPSGCSDIAYPKLV---LELLPTGLRGLMMAVMVAALMSSLTSIFNS 395

  Fly   359 LATVIWEDFISQL-PKFKGLSDKQQLRILKSITVVCGLIIMGVAFGVGLLAGVIESS----LLVF 418
            .:|:...|..:.| |:    :.:::|.|:..:.|:. |:::.:     |...|:::|    |.::
Human   396 ASTIFTMDLWNHLRPR----ASEKELMIVGRVFVLL-LVLVSI-----LWIPVVQASQGGQLFIY 450

  Fly   419 -----SATSGPLLGCFILAMMVPIANWKGTSAGMVTACAFVLWIIGGGMTVTKDNPLLPTSTDGC 478
                 |....|:...||:.......|.||...|:::.      ::.|.:.:..|
Human   451 IQSISSYLQPPVAVVFIMGCFWKRTNEKGAFWGLISG------LLLGLVRLVLD----------- 498

  Fly   479 TNDTFAQSIGKPIVEQGQMPWLLSHTPIDGFNQSFVPTQPTI--APERSGLETFYSISFMYYSLI 541
                                              |:..||..  ..||..|  ..||.::|:|:|
Human   499 ----------------------------------FIYVQPRCDQPDERPVL--VKSIHYLYFSMI 527

  Fly   542 GTALTVIIGTVISLLTQHPDDAYDGKLLHPLIFRLCERFSGRKPYYVKHE-----------EESG 595
            .:.:|:|..:.:|..|:.|..    :::..|.:     |:...|...|.:           .::|
Human   528 LSTVTLITVSTVSWFTEPPSK----EMVSHLTW-----FTRHDPVVQKEQAPPAAPLSLTLSQNG 583

  Fly   596 LNGRSSSDSSATTTTCKAEKVNHGYESSPEDKE 628
            :...|||.|.......:.....|..:.:|:..:
Human   584 MPEASSSSSVQFEMVQENTSKTHSCDMTPKQSK 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7720	NP_001163649.1	SLC5sbd_NIS-SMVT	10..556	CDD:271383	126/598 (21%)
SLC5A11	NP_001339171.1	SLC5sbd_SGLT6	28..675	CDD:271381	139/683 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910