DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7720 and Slc5a5

DIOPT Version :9

Sequence 1:	NP_001163649.1	Gene:	CG7720 / 42257	FlyBaseID:	FBgn0038652	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_444478.2	Gene:	Slc5a5 / 114479	MGIID:	2149330	Length:	618	Species:	Mus musculus

Alignment Length:	561	Identity:	175/561 - (31%)
Similarity:	284/561 - (50%)	Gaps:	34/561 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 STMG-WDYLMFVLFIALTVLGPLWKRIFGKKKERSKADYVFATGGVSIVAVMI--SIARGTLGVR 67
            :|.| |||.:|...:.::....||..: .:..:||..|  |.|||..:.||.:  |:|...:...
Mouse    10 ATFGPWDYGVFATMLLVSTGIGLWVGL-ARGGQRSADD--FFTGGRQLAAVPVGLSLAASFMSAV 71

  Fly    68 SVLGYPSELYYRG-SAMWEIIYGMMSAYPIVCFMFVPVYFNLGITSVYQYIDLRFKSRTVRCLAS 131
            .|||.|:|....| ..:|..:..::::. :...:|:|:::.||:||.|||::||| ||.||...:
Mouse    72 QVLGVPAEAARYGLKFLWMCVGQLLNSL-LTALLFLPIFYRLGLTSTYQYLELRF-SRAVRLCGT 134

  Fly   132 ATYIVRQICNLGITVYTPSVALSTVIGIPYWASITGMAVICIFFTIMGGLKAAINADVIQTVTIL 196
            ..|:|..:...||.:|.|::.|:.|.|:..|||:....:||..:|.:||:||.:..||.|.|.:|
Mouse   135 LQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVML 199

  Fly   197 VVTVAVCIQGTISTGGVKKVYQLNRDNGRLNFWNFTGDMTVRVDTTSAWLGQLFMSLSQIGCQQN 261
            |....:..:|.:..||...|..|.:::.|:|..:|..|...|....:..:|...:.||..|..|.
Mouse   200 VGFWVILARGVMLMGGPWNVLSLAQNHSRINLMDFDPDPRSRYTFWTFVVGGSLVWLSMYGVNQA 264

  Fly   262 FMQRYVSLKSLKQVRRVMLTNVPLVFFFFSISWISGMVIYSTYINCDPYAEGYIKKPDEILPFFV 326
            .:||||:..:.::.:..:|.|...:|...:.:...|:|::..|.:|||...|.|..||:.:|..|
Mouse   265 QVQRYVACHTERKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRIAAPDQYMPLLV 329

  Fly   327 EDQLGFLPGFVGIFMATLFNGALCMMVSNLNSLATVIWEDFISQLPKFKGLSDKQQLRILKSITV 391
            .|....|||..|:|:|..::|.|....:::|::|.|..||.|.  |:...|:.::.:.|.|.::.
Mouse   330 LDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIK--PRMPSLAPRKLVFISKGLSF 392

  Fly   392 VCGLIIMGVAFGVGLL-AGVIESSLLVFSATSGPLLGCFILAMMVPIANWKGTSAGMVTACAFVL 455
            :.|...:.||....|| .||::.|..|....||||||.|.|.|::|..|..|..:|:....|..|
Mouse   393 IYGSTCLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLTAGLAVSL 457

  Fly   456 WIIGGGMTVTKDNP---LLPTSTDGCTNDTFAQS-IGKPIVEQGQMPWLLSHTPIDGFNQSFVPT 516
            |:..|.........   :||||..||||.:...| .|.....:|        .|..|.:..
Mouse   458 WVAVGATLYPPGEQTMGVLPTSAAGCTNASVLPSPPGAANTSRG--------IPSSGMDSG---- 510

  Fly   517 QPTIAPERSGLETFYSISFMYYSLIGTALTVIIGTVISLLT 557
            :|..|      :|||::|::||..:||..|::.|.:||.||
Mouse   511 RPAFA------DTFYAVSYLYYGALGTLTTMLCGALISYLT 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7720	NP_001163649.1	SLC5sbd_NIS-SMVT	10..556	CDD:271383	171/553 (31%)
Slc5a5	NP_444478.2	SLC5sbd_NIS	15..549	CDD:271393	173/556 (31%)
Slc5a5	NP_444478.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	571..618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820