DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7720 and slc5a8

DIOPT Version :9

Sequence 1:	NP_001163649.1	Gene:	CG7720 / 42257	FlyBaseID:	FBgn0038652	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_021331097.1	Gene:	slc5a8 / 100329285	ZFINID:	ZDB-GENE-141211-63	Length:	609	Species:	Danio rerio

Alignment Length:	576	Identity:	151/576 - (26%)
Similarity:	274/576 - (47%)	Gaps:	93/576 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WDYLMFVLFIAL-TVLGPLWKRIFGKKKERSKADYVFATGGVSIVAVMISIARGTLGVRSVLGYP 73
            |||::|::.:|: |.:|..:  .|..:.:.|.||::.|...:|...|.:|:....:...:|||.|
Zfish    11 WDYVVFIMMLAVSTGIGVYY--AFAARSQSSSADFLVAGRSLSAPPVALSLTASFMSAITVLGTP 73

  Fly    74 SELYYRGSAMWEIIYGMMSAYPIVCF-----------MFVPVYFNLGITSVYQYIDLRFKSRTVR 127
            .|:|..|           :.:.::||           :|:||::.||:||.|
Zfish    74 VEVYKYG-----------AIFILICFAYAFMVALSSEIFLPVFYRLGVTSTY------------- 114

  Fly   128 CLASATYIVRQICNLGITVYTPSVALSTVIGIPYWASITGMAVICIFFTIMGGLKAAINADVIQT 192
                      ::...|:.:|.|::||:.|.|:..|.::....|:|..:..:|||||.:..||.|.
Zfish   115 ----------EVLYTGLVIYAPALALNQVTGVDLWGAVISTGVVCTLYCTLGGLKAVVWTDVFQV 169

  Fly   193 VTILVVTVAVCIQGTISTGGVKKVYQLNRDNGRLNFWNFTGDMTVRVDTTSAWLGQLFMSLSQIG 257
            ..:|...:||.:|..:..||:.::...:...||:|.|:|..:...|....|..:|..|...|..|
Zfish   170 GIMLAGLLAVIVQSVLLQGGIPRIISDSAHGGRINLWDFDPNPLRRHTFWSITVGGTFYWTSFYG 234

  Fly   258 CQQNFMQRYVSLKSLKQVRRVMLTNVPLVFFFFSISWISGMVIYSTYINCDPYAEGYIKKPDEIL 322
            .....:|||:|.|||...:..:..|:..::.....:...|:.:||.|.||||:....:...|:::
Zfish   235 INHAQVQRYISCKSLIHAKMALFINLVTLWVVTFCAVFCGLCLYSVYKNCDPWMAKKVSAQDQLM 299

  Fly   323 PFFVEDQLGFLPGFVGIFMATLFNGALCMMV-----SNLNSLATVIWEDFISQLPKFKGLSDKQQ 382
            |:.|.|.|...||..|:|:|..::|....:|     |::|:||.|...|.   |..:..||:||.
Zfish   300 PYLVLDILSEFPGLPGLFVAAAYSGTFMFIVNSTVSSSVNALAAVTVTDV---LRPYLSLSEKQL 361

  Fly   383 LRILKSITVVCGLIIMGVAFGVGLLAGVIESSLLVFSATSGPLLGCFILAMMVPIANWKGTSAGM 447
            ....|::::..|.:.:|:|....::.|:::::..:.....|||||.|.||::.|.||.||..||:
Zfish   362 SWASKAMSLFYGAVCIGMAGIASMMGGMLQAAFSISGVIGGPLLGLFSLAILFPCANSKGGLAGL 426

  Fly   448 VTACAFVLWIIGGGMTV---TKDNPLLPTSTDGC--------TNDTFAQSIGKPIVEQGQMPWLL 501
            |:.....||:..|....   .:::..|..:|.||        ||.|.:..|.:  :|:..:
Zfish   427 VSGLGLSLWVCIGAQIYPPPAENSRPLTLNTHGCNLSMAPDTTNWTASMDIYR--IEEETL---- 485

  Fly   502 SHTPIDGFNQSFVPTQPTIAPERSGLETFYSISFMYYSLIGTALTVIIGTVISLLT 557
                          .:|.:|      :.:||:|::|:.|:||...:.:|.::|:|:
Zfish   486 --------------ERPLLA------DNWYSLSYLYFGLLGTVTAIAVGLIVSILS 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7720	NP_001163649.1	SLC5sbd_NIS-SMVT	10..556	CDD:271383	150/573 (26%)
slc5a8	XP_021331097.1	SLC5-6-like_sbd	6..527	CDD:320982	151/576 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920