DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Epg5 and Epg5

DIOPT Version :10

Sequence 1:NP_650752.2 Gene:Epg5 / 42256 FlyBaseID:FBgn0038651 Length:2455 Species:Drosophila melanogaster
Sequence 2:NP_001182562.1 Gene:Epg5 / 100502841 MGIID:1918673 Length:2572 Species:Mus musculus


Alignment Length:2713 Identity:627/2713 - (23%)
Similarity:1121/2713 - (41%) Gaps:473/2713 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MATLEKPKKEKSKKSRNRVPIEK------------------EEEEP------------------- 28
            ||...||::.|:|.||.:...:|                  |:|.|                   
Mouse     1 MAEAVKPRRAKAKASRTKGKEKKKHEALQTCDAGPLPETCREQESPCPASELKGDDLKSSADPQL 65

  Fly    29 -----------------AELSTSEEQRPAENVSLLEEFERVATLASSSSGEAIISHECCISSDVG 76
                             ..|:..:|..|.::...|:|...|      ::|:.  ..|..:..|.|
Mouse    66 HSDVCGWNESEMFDIPLTSLTIGDEGPPVQDTEDLKERGEV------TAGDG--DDEMELKVDPG 122

  Fly    77 ---VTSQEPEGTQEPTETEAQPSAPSAPPSTTVHVVQYPNLQPMQLSNAQVEEHSAKIVYRQAES 138
               :...||  .:...|.|........||.:|:. ..:|..| ..:..:...||..:   :|.|:
Mouse   123 DNVIAKGEP--CKNFPEVEDHTLIQCGPPESTLQ-PDFPCTQ-QAVEGSHAREHPTR---KQDEA 180

  Fly   139 PTGFALARSHIKLLSTEELRQIYDCPEL-------------------------------ELAKQF 172
            ..|.:....::.|.|:.|.:::...|.:                               ||..|.
Mouse   181 ALGCSKVFQNVSLHSSYEAKEVSQPPRVKKLYPELPAEIAEVPALVAVKPLLRSERLYPELPSQP 245

  Fly   173 EL--------------EFLMNSLLETSEADPL--------YAAVMEYYELQGKITSNLHDVEKLR 215
            |:              .:|.|......|.|.:        |..::.|...:.::.....::..|.
Mouse   246 EVTPFTKEQLKLLEPGSWLENVASYVEEFDNIAHQDRHEFYELLLNYSRCRKQLLLAEAELLTLM 310

  Fly   216 KGCAESQKQIWVRQPVTRTFSGTCGDGNVVQECVTYDVIQVDPIKLEVAKTSLTGLYD------- 273
            ..|..::.::|..:.......|.|.|...|.....|..::::    |.....|..|:|       
Mouse   311 SDCHSAKSRLWHFKDEQMAVQGICADQVKVYGHHHYQRVEMN----ENVLGELKKLFDAKSEHLH 371

  Fly   274 --LVCHAYTNNSITAKITKVKVDQIINDLLTYPNLDGHSVVSLHHTQSGEALQC----------V 326
              |..|:|     |:.:::::|:..|..||       :|..:|......:|.|.          |
Mouse   372 QTLTLHSY-----TSVLSRLQVESYIFTLL-------NSSAALRSLAVYQADQVPKLTESIPSDV 424

  Fly   327 SQLRRAISILFSFVRRPSPNANFDKDLKEWLRKLIALQLLLATREDHWFLLFNILRCPNGVGSWA 391
            .||:..||:||.|.||.|.:|.|.:|:..||:||:::...:....||:|||.::||||.|:..||
Mouse   425 CQLKECISVLFMFTRRVSEDAQFHEDILLWLQKLVSVLQRVGCPGDHFFLLNHVLRCPAGIRKWA 489

  Fly   392 AQFLQLPGTRAVRRGSQQNELPLDLNSPE-LNHCMAVLQILLMPVKKRNEYLKSQAQAHRELSDT 455
            ..|:|:.                .||:|. :.|.|..|.:|:.|||.|.|::.....:..:.|.:
Mouse   490 VPFIQIK----------------VLNNPSGVFHFMQSLALLMSPVKNRAEFMCHMKPSEWKPSSS 538

  Fly   456 PGATDRWIVVDSDGEDSHTPAGECVGLKESDLVALLNQMPFEKIFTSALRIEKFLDDYIIEPDMI 520
            ..|:..|.:||..||:...|....:.|.|.|||.||:|.||:::|...|.. |...||:  |:..
Mouse   539 GPASGNWTLVDEAGEEDEDPETSWILLNEDDLVTLLSQFPFQELFQHLLGF-KAKGDYL--PETT 600

  Fly   521 TAQQMLAVVVFFSQLVKTIGEGLLTYNNERYKQLAKRLGRLVRHTLQYVFDYNELFINNN----L 581
            ..|:|:.:..|.:.||:.:..||.|:|..||:|..||:|.|:|.||.||.|:...:::::    |
Mouse   601 RPQEMMKIFAFANSLVELLAVGLDTFNRARYRQFVKRIGYLIRMTLGYVSDHWAQYVSHSTGAGL 665

  Fly   582 YKSSEMYERIQVELQALLVRACGYIYRTRNLGTWQYFSTLPFGTLDAEVIWHLFYYLNVGFPTDL 646
            .......|::|||...|.:||..::.:.:.||.|.:.|.:|||||..:::|.|.|.::.....||
Mouse   666 TPQPYSMEKLQVEFDELFLRAVLHVLKAKRLGIWLFMSEMPFGTLSVQMLWKLLYLMHQVESGDL 730

  Fly   647 ANDLVSNAEAA-----FQAEDFWRKFDLANADVAPEDMYYLLQTFFEMANERNRSKDGSLVKAIC 706
             ..|.::.:.|     .|..:.:..|:...:.:...:...||..|.:||..|..:.|...:|.|.
Mouse   731 -QQLCASLQPAECKRRLQDPEHFASFEKCLSSINSSEEICLLTAFAQMARARRTNVDEDFIKIIV 794

  Fly   707 LHIFHIGYIHKSTREICYKTARDMLANL--MDEDLFGCVLVQLKMRYGEVDQAA-YLFKALPLEN 768
            |.|:.:.|:..||||...|..|::|..:  :..::...:|.:::....:|...: ||||.|||..
Mouse   795 LEIYEVSYVTLSTRETFSKVGRELLGAIAAVHPEIISVLLDRVQETIDQVGMVSLYLFKELPLYL 859

  Fly   769 WHPSMDTFEVLSNWLLHFDYQSSESQLARLIISHLNWGLDCEGRLFLPHNIHVRMAHLVNEALNK 833
            |.||.....|:.:|||:.:..:.:::||.:|:..||||...:|.|.|...:|..:|.||.||..|
Mouse   860 WRPSAPEIAVIRDWLLNNNLTAVKNKLACVILEGLNWGFTEQGTLHLDQALHTEVALLVLEAYQK 924

  Fly   834 YAPEVIGASGISESVRQVS---SLIDSTQSSREQFTNWCWRMVSVLRLHLMDQGVESVR-----R 890
            |..:......||||::|||   |::...::....|..|.|.::..|:||..|.|.::..     .
Mouse   925 YLAQKPYTGLISESMKQVSYLASIVRYGETPETSFNQWAWNLILRLKLHKNDFGRQNFPVIPFCS 989

  Fly   891 TLQHPTEPLLFIPELERMEMIFQGVNENRPLALYVGMLVSLHGHSIPLICQHGFILLQQLLLDHR 955
            |:...||..:|.|       :.:.|....|:..|:.:.|:..|||:...|..|..||..|:....
Mouse   990 TVPDMTESSMFHP-------LLKAVKSGLPIGCYLALAVTAVGHSLEKFCAEGIPLLGVLVQSRH 1047

  Fly   956 HAATIRCLELIVPLFLETPETLANCESFQRLITTLLNAD---------RTYLKLAKDMVYANSIG 1011
            ..|.:..|:.|:|:|......|...|.|...:...|..|         :...::|:.:..|.. |
Mouse  1048 LRAVVHALDKILPVFYPYQCYLLKNEQFLSNLLLFLQLDSGVPQGVTQQVTHRVAQHLTGAVH-G 1111

  Fly  1012 PILELLDNMLHHQIISYTSYGLCSPLNLLNIWLNCFTTLPGWSQNSNLLYLLDRMLRISYQF--P 1074
            ..::||.:|:...|...|......|:.:|..|:....:...|.:...:|:|:|.:.:.::..  .
Mouse  1112 DNVKLLSSMIQAHICVSTQPDGVGPVAVLEFWVQALISQHLWYREQPILFLMDHLCKTAFHLMQE 1176

  Fly  1075 DCRAQAVEFFYNYYKDC-------------TEWKSAPKGSALKAFFGGQSVSRIPLISPQNCWLN 1126
            ||   ..:..|..:|:.             ..|..|  |:...:|..|.|.|       ...|..
Mouse  1177 DC---VQKLLYQQHKNALGYHCDRSLLSSLVNWIVA--GNITPSFVEGLSTS-------TQVWFA 1229

  Fly  1127 LVILEIEFRLVDTRIFPE--LLRQ-------ISAQPVEAALKKTISLSKTSAFPASQ-LVIFKYA 1181
            ..:|.:|      .||.|  .||:       |:|...:.||||.....|....|:.| |:|:::|
Mouse  1230 WTVLNME------SIFEEDSQLRRVVERELVINAFSPDQALKKAQVQLKLPIVPSLQRLLIYRWA 1288

  Fly  1182 QLLASMESTHALFPIVCQKFFELYLWR------VPTENESLNFSHNFGVSDKFYE--YNVPLMKS 1238
            .......|.|.|.|::.||||.|||.|      :|.:.         .:..:|::  .:|.|:|.
Mouse  1289 HQALVTPSDHPLLPLIWQKFFLLYLHRPGPQYGLPVDG---------CIGRRFFQSPSHVNLLKD 1344

  Fly  1239 IKSQL-KSAESYYSALAT-------KNANDDAMA---------HFYRNCCKLMQNCALWLEDTQI 1286
            :|.:| :.|:.:|:|...       .....:..|         ..:|...:|.....|||||...
Mouse  1345 MKRRLTEVADFHYAASKALRVPAEGSEGTPEGQAGTPGFLTSPELHRELVRLFNVYVLWLEDENF 1409

  Fly  1287 NRFTSDAEHLPAQYNSEKLRELLSGHVNHWTEFLCLASLRKEQRHQADQWGRKVMRLSNQKAP-- 1349
            .:..:....||..|:..:|.:::....:.|.|::.:..::.|.:.....|.:  .:|.:..||  
Mouse  1410 QKGDTYIPSLPKHYDVHRLAKVMQNQQDLWMEYVNMERIQHEFQETVALWTQ--AKLESHAAPCS 1472

  Fly  1350 -------RTPVQPKQRQPPAQHIKSLLKSYEKIVENP---LHIRVEPIKTPPIDGVIVAQI--QK 1402
                   ..|:..|.|      :.|.|:.:|  ..:|   ||    |:: ||:..:..|.:  ||
Mouse  1473 SSAQLDFTDPLLAKAR------VLSNLEKHE--APHPPLLLH----PVR-PPVPLIPSAALLTQK 1524

  Fly  1403 KMTTLNST--------ANNYHYKTSELNSLDLNYLERVPTLYSMIPYEETRRKECTSLLFKRNCT 1459
            ..|.|..|        |.:...:.|:..:||...||.:|..|.....:.|...||.....|: |.
Mouse  1525 DSTQLMCTDLNLLQQQARSATLRESQQVALDGELLETMPKQYVNREDQATLHLECRGSSGKK-CQ 1588

  Fly  1460 APAQIKLTPEHIRINDVISRK----QAQNRERHDKIIEDILLAMSVESFAQAIEELGVCIGALLV 1520
            ..|.:.:..|.:..|:.:|::    |.:.|:...:..:...|.: ||:...|...:...:....:
Mouse  1589 GAAVVTVQFEGMNKNEAVSQQIHVLQKEVRQLQAEAAQPPALNV-VEAAVHAENLITALVNTYKL 1652

  Fly  1521 APLESSVTQIGVRVFYDIVDNLNEVTMKFQPTHDLYFQVLEKLGVFLEADQAAQGLAILRLALKR 1585
            .| ...|.::|:.:|:.:||::::.|.:..||...:...:|.||....:...::...:|:..||.
Mouse  1653 QP-TPGVQKLGISLFFTVVDHVSDETQRHPPTRQFFTSCIEILGQVFVSGTKSECRKLLQTILKN 1716

  Fly  1586 PDLLELLAGVFVPSRTDVDHFLSMYEFLIDSHLKHCDTQTLFVLFSKFDLLGWMEAYQPKLSEIN 1650
            ..|..|||..|.|:....: |:.:||.:: :.|:..::..:|:|.:|||:..|:.:.:|.||:..
Mouse  1717 RRLCSLLAPFFTPNAAPAE-FIQLYERVV-TCLREDNSDVIFMLLTKFDIQQWLNSTKPPLSDRT 1779

  Fly  1651 RLLLLVLQGLEAWS-QPDSSLLQ--DLFRRHLVHIFGYDFPQHYGEVMQLVLDRTSDQKLMPVVL 1712
            |||..:...|.||. :|:..:|.  :||.:|..|:..|.||..|.:|::|::..:::|.|.|...
Mouse  1780 RLLESIHLALTAWGLEPEEDILMPFNLFCKHWTHLLLYQFPDQYSDVLRLLVQSSAEQLLSPECW 1844

  Fly  1713 LDLLNALFVRSNCAELSLQQSEVRVHELALDFARRQKLFTLKAATDTLLLLSRHFQK---ERLHH 1774
            ...|.||    .|...|.||....|....|..|.| .|.:.|...:|:..||..|.|   .:|..
Mouse  1845 KATLRAL----GCYAPSSQQGAASVESSGLHSASR-VLLSDKQVMETVQWLSDFFYKLRLSKLDF 1904

  Fly  1775 GLHGLYPKHKDYCQALVLWFTSFGH-----------TLLASAICSYQELLADQISDIVFGSIVET 1828
            ...||:.|...|...:.   |..|:           :|......|.:|:|..     :...|::.
Mouse  1905 KSFGLFSKWSPYMADVK---TFLGYLVKRLTDLEIASLSQDPTASSKEVLRS-----LHAQIIQL 1961

  Fly  1829 YSPWLIPYTEETVSGVAHWIRQLTPGQSKVLLPWSEQHVSSCKLMIRSFVATIIQVLQYLPSSNK 1893
            :.||::...:...|...|:             ||.|...:....:::.|...:..:  :....::
Mouse  1962 FKPWILVLEDAESSHQRHY-------------PWLESDTAVASSIVQLFSDCVGSL--HTSFKDR 2011

  Fly  1894 IL---EHVFAWYVHHFAQSSTT----GHVLAPIHEGLAQLPWERFLPPAQHVELLYDSLQKFLPE 1951
            :|   |.....::.|:.::.|.    ..:|...|....:|.|:...|..:.:|..: .:::..|:
Mouse  2012 LLPGDEGALRLHLLHYCETCTAPKMPEFILYAFHSAYQRLEWKDLHPDQRLMEAFF-KVERGSPK 2075

  Fly  1952 S-HAMLGHIFIRIEW-----NNWF-AQMPQPVSILSRLFTIFVKIAFEPNIHIHPNTS--KILED 2007
            | ...||.:..|:.|     :.|. :.:|:..|:...|..:.|.:|.|..:...|::.  .:|..
Mouse  2076 SCFLFLGSVLCRVNWVSVLSDAWNPSPLPETQSMAVCLLFMMVLLAKEAQLVDEPDSPLLSLLGQ 2140

  Fly  2008 AIRYPWHLVECSELEQLLKWFVASVEPAIALKIPAESNYADRAVLELLRLACAMLPERSAQDAVV 2072
            .....||||:....:.:|.:|.:...|::.|    .::.:...:::||:::..:......:..|.
Mouse  2141 TSSLSWHLVDLVSYQSVLGYFSSHYPPSVVL----ANDCSSELIVKLLKVSAGLSAHADGRKHVD 2201

  Fly  2073 LGTAKRMLYTRSMVRMQRACGAKHQKLLATKEGER----AFSNAFLELLDSI----DGAISSCSE 2129
            : ..|...:|..||          |.|.|.::..:    |......:|||.|    ...:.|.:.
Mouse  2202 I-VPKCQAFTHQMV----------QFLSALEQTGKITFPALEREISKLLDDIIIFNPPDMDSQTR 2255

  Fly  2130 HRTMEEQRREALNLMLELVAPTQTQSQEVSNIHIKALVWWQQRCSPGNLVM------CSTLPAIG 2188
            |..:.....|.|.:|.....||    .|...:.|:  .|..||.. |.:|:      |.:|.::.
Mouse  2256 HMALSSFFVEVLMMMNNAAVPT----AEFLAVSIR--TWIGQRVH-GLIVLPLLTAACQSLASVR 2313

  Fly  2189 HLNTYIASIYSLLEASIENYFRTSPEIASWHAPSWQGLMEALSMSLPKLDLMPIMQ-----GSYF 2248
            |:       ..:.||.|..||:.|....:.   .|..::  :|:.:|:|.....::     || .
Mouse  2314 HM-------AEITEACIMAYFKESSLDQNL---GWGPVL--VSLQVPQLTARDFLEECLALGS-C 2365

  Fly  2249 FSLHVFVLYKMEEIATDGDKVTFLQDLSQLLENL-KTSPQTEPRMALVWGVIIARG-CQIAQ--- 2308
            .:|:|::|..:....|..:.:..|..:|..||.: .:|.|.|.::.|.|..|:... .|:.|   
Mouse  2366 LTLYVYLLQCLNSEQTVKNDMKMLLVVSGWLEQVYPSSAQEEAKLFLWWHQILQLSLIQLEQNDS 2430

  Fly  2309 -VNQQVKKPLHMLARHLQIASTKAEGWGDGLLGVIGL-KSEVITNRRKVLTRCLACVIFSLFPAN 2371
             :.:.|.:.|.||.....:.:  .|....|:||.||| :...::||.:|..|.:|..:....||.
Mouse  2431 VLTESVIRILLMLQSRQSLMA--EERLSSGILGAIGLGRRSPLSNRFRVAARSMAAFLLVQVPAE 2493

  Fly  2372 RDLRI-PSEEY------ESALRELSMLLANKKFTDIKPLIVRAVSLLK 2412
            ..:|: ||.|.      :..|..|..:..:|::.:.:..|:.|:..::
Mouse  2494 DQIRLKPSSELHLAPKAQQVLTALESMTLSKQYVEYQDQILHALQFIR 2541

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Epg5NP_650752.2 None
Epg5NP_001182562.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..68 19/120 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 84..125 7/40 (18%)

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