Protein Alignment PGS1 and PGS1

DIOPT Version :10

• Sequence 1: NP_650751.3
• Gene: PGS1 / 42254
• FlyBaseID: FBgn0038649
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: XP_011523789.1
• Gene: PGS1 / 9489
• HGNCID: 30029
• Length: 646
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 224/526 - (42%)
• Similarity: 313/526 - (59%)
• Gaps: 53/526 - (10%)

  Fly     3 PYLRRLFSQELSPAAQGDFLGCLQQAPSVLATGFPGAP-ALESLSWLHNLAPCFPLRGDQIQVIH 66
            |:|  |.:..||||           .|.|.:......| .:....|:.||.|.|.:....::|:.
Human   140 PWL--LLAPLLSPA-----------VPQVTSPPCCLCPEGVHRFQWIRNLVPEFGVSSSHVRVLS 191

  Fly    67 EPKHFYETLVQRIGQAKRRIVLASLYLGTGQLENAMVQTLRHSLEQQ------SALRLNVLLDFT 125
            .|..|:|.:..:|..||||:|:||||||||.||..:|..|..:||:.      |.|::::|||||
Human   192 SPAEFFELMKGQIRVAKRRVVMASLYLGTGPLEQELVDCLESTLEKSLQAKFPSNLKVSILLDFT 256

  Fly   126 RGTRGTLNSKTMLLPLVRDFASQVQLSLYHTPDLRGMTKRLAPPRWNELLGLQHMKVYLFDDAVI 190
            ||:||..||:||||||:|.|..||::||:|||.|||:.:.|.|.|:||.:||||:||||||::||
Human   257 RGSRGRKNSRTMLLPLLRRFPEQVRVSLFHTPHLRGLLRLLIPERFNETIGLQHIKVYLFDNSVI 321

  Fly   191 ISGANLSNDYFTNRQDRYILIED-KPLADFYAQFIERVQEFSLAVAPDAS----EGLHRNWRILP 250
            :||||||:.|||||||||:.::| ..:|||:.:.::.|.:.||.:..|.:    :|:     :.|
Human   322 LSGANLSDSYFTNRQDRYVFLQDCAEIADFFTELVDAVGDVSLQLQGDDTVQVVDGM-----VHP 381

  Fly   251 YEGTKEQFIQLARKRISDLVQETFQRQ-------------------ARTKEQNPQADTWIFPLLE 296
            |:|.:.::.:.|.||:.|::.....||                   |...::.|..||||:||::
Human   382 YKGDRAEYCKAANKRVMDVINSARTRQQMLHAQTFHSNSLLTQEDAAAAGDRRPAPDTWIYPLIQ 446

  Fly   297 MGQIGIHHDSVVTKRLLSNCLSGSRLKLATGYFNLTQEYMDTLTHKCLAQCSILMAHPNANGFQG 361
            |....|..|.:||:.||:....|:::.|.||||||||.||| |.....|:..||:|.|..|||.|
Human   447 MKPFEIQIDEIVTETLLTEAERGAKVYLTTGYFNLTQAYMD-LVLGTRAEYQILLASPEVNGFFG 510

  Fly   362 AKGPAGGIPAAYTLIAKSFYESLVRRKQNHRVNFFEYEKPGWTYHAKGLWYYLPEAILPNLTLIG 426
            |||.||.|||||..|.:.|:..:....|..||...||.:.|||:||||||.||..:.||.|||||
Human   511 AKGVAGAIPAAYVHIERQFFSEVCSLGQQERVQLQEYWRRGWTFHAKGLWLYLAGSSLPCLTLIG 575

  Fly   427 SSNFGERSVNRDLETQVCLVTANKDLSQRLQAEADRLY---DLSQTAEREIVQRPVPRWVQAVVR 488
            |.|||.|||:||||.|:.:||.|:.|.|:|..|.::||   .:..:|..|...|.|..||:.|..
Human   576 SPNFGYRSVHRDLEAQIAIVTENQALQQQLHQEQEQLYLRSGVVSSATFEQPSRQVKLWVKMVTP 640

  Fly   489 IFRNFF 494
            :.:|||
Human   641 LIKNFF 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PGS1	NP_650751.3	PLDc_PGS1_euk_1	61..227	CDD:197233	91/172 (53%)
		PLDc_PGS1_euk_2	289..474	CDD:197235	92/187 (49%)
PGS1	XP_011523789.1	PLDc_PGS1_euk_1	186..359	CDD:197233	95/179 (53%)
		PLDc_PGS1_euk_2	439..598	CDD:197235	83/158 (53%)