Protein Alignment PGS1 and PLD1

DIOPT Version :10

• Sequence 1: NP_650751.3
• Gene: PGS1 / 42254
• FlyBaseID: FBgn0038649
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_002653.1
• Gene: PLD1 / 5337
• HGNCID: 9067
• Length: 1074
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 123/680 - (18%)
• Similarity: 204/680 - (30%)
• Gaps: 256/680 - (37%)

  Fly     4 YLRRLFSQELSPAAQGD--FLGCL-----QQAPSV---------LATGFPGAPALESLSWLHNLA 52
            :|:|       |..:|:  .|.|:     ||...:         ||.|........:|..||
Human   388 FLKR-------PVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLH--- 442

  Fly    53 PCFPLRGDQIQVIHEPKHFYETLVQRIGQAKRRIVLASL-YLGTGQLENAMVQTLRHSLEQQSAL 116
                   ..|:|:..|.|...|:.......|..|:..|: ::|...|.........|.|....::
Human   443 -------PNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSV 500

  Fly   117 RLNVLLDFTRGTRG-TLNSKTMLLPLVRDFASQVQLSLYHTP---------------DLRGMTKR 165
            :        |.|.| :|.|   |.|...:....::|...:.|               .|:|:.|
Human   501 K--------RVTSGPSLGS---LPPAAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGK- 553

  Fly   166 LAPPRWNELLGLQHMKVYLFDDAVIISGANLSNDYFTNRQDRYILIE------------------ 212
              |.::::....:.:..:...||..||..:.::.||.:.:..:.||.
Human   554 --PRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHFKLFHPSSESEQG 616

  Fly   213 --------------------------------------------DKPLADFYAQFIERVQEFSLA 233
                                                        |||.|||       :..:|..
Human   617 LTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADF-------IDRYSTP 674

  Fly   234 VAP--DASEGLHRNWRILPYEGTKEQFIQLARKRISDLVQETFQRQARTKEQNPQADTWIFP-LL 295
            ..|  |.:..:|                   .|...|:.:...||...||....:..:..:| ||
Human   675 RMPWHDIASAVH-------------------GKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLL 720

  Fly   296 EMGQIGIH----------HDSVVTKRLLSNCLSGSRL---KLATGYFNL---TQEYMDTLTHKCL 344
            ...|...|          |.:|...|..::..:|.:.   .:...|.::   ::.|: .:.::..
Human   721 PKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYI-YIENQFF 784

  Fly   345 AQCS----------------ILMAH------------PNANGFQGAKGPAGGIPAAYTLIAKSFY 381
            ..|:                ||.||            |...||:|.....||  .|...|....|
Human   785 ISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGG--NALQAIMHFNY 847

  Fly   382 ESLVRRKQ-----------NHRVNFFEYEKPGWTYHAK-------GLWYYLPEAIL--PNLTLIG 426
            .::.|.:.           |..:|:..:  .|...||:       .|.|...:.::  .|..:||
Human   848 RTMCRGENSILGQLKAELGNQWINYISF--CGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIG 910

  Fly   427 SSNFGERSV--NRDLETQVCL--------VTANKDLSQ-------RLQAEADRLYDLSQTAEREI 474
            |:|..:||:  .||.|..|.:        |...|:...       |||.....|..|...:|.
Human   911 SANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSED-- 973

  Fly   475 VQRPVPR------WVQAVVR-------IFR 491
            :|.||..      ||....|       :||
Human   974 IQDPVSDKFFKEVWVSTAARNATIYDKVFR 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PGS1	NP_650751.3	PLDc_PGS1_euk_1	61..227	CDD:197233	39/244 (16%)
		PLDc_PGS1_euk_2	289..474	CDD:197235	52/266 (20%)
PLD1	NP_002653.1	PLN02866	82..1059	CDD:215467	123/680 (18%)
		Catalytic	463..928		87/509 (17%)