DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7718 and Pgs1

DIOPT Version :9

Sequence 1:	NP_650751.3	Gene:	CG7718 / 42254	FlyBaseID:	FBgn0038649	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_006247917.1	Gene:	Pgs1 / 303698	RGDID:	1305052	Length:	553	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	212/481 - (44%)
Similarity:	296/481 - (61%)	Gaps:	39/481 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 WLHNLAPCFPLRGDQIQVIHEPKHFYETLVQRIGQAKRRIVLASLYLGTGQLENAMVQTLRHSLE 111
            |:.||.|.|.:....::|:..|..|:|.:..:|..||||:|:||||||||.||..:|..|..|||
  Rat    79 WIRNLVPEFGVSSSHVRVLSSPAEFFELMKGQIKIAKRRVVMASLYLGTGPLEQELVDCLESSLE 143

  Fly   112 QQ------SALRLNVLLDFTRGTRGTLNSKTMLLPLVRDFASQVQLSLYHTPDLRGMTKRLAPPR 170
            :.      |.|::::|||||||:||..||:||||||::.|...|::||:|||:|||:.:.|.|.|
  Rat   144 KSLQAKFPSDLKVSILLDFTRGSRGRKNSRTMLLPLLQRFPEHVRVSLFHTPNLRGLLRLLIPER 208

  Fly   171 WNELLGLQHMKVYLFDDAVIISGANLSNDYFTNRQDRYILIED-KPLADFYAQFIERVQEFSLAV 234
            :||.:||||:||||||:.||:||||||:.|||||||||:.::| ..:|||:.:.::.|.:.||.:
  Rat   209 FNETIGLQHIKVYLFDNNVILSGANLSDSYFTNRQDRYVFLQDCAEIADFFTELVDAVGDVSLQL 273

  Fly   235 APDAS----EGLHRNWRILPYEGTKEQFIQLARKRISDLVQETFQRQ------------------ 277
            ..|.:    :|:     :.||:|.:..:.:.|.||:.|::.....||
  Rat   274 QGDDTVEVVDGM-----VHPYKGDRAAYCRAANKRVMDVIHSARTRQQMLHAQTFHSDSLLSQEE 333

  Fly   278 -ARTKEQNPQADTWIFPLLEMGQIGIHHDSVVTKRLLSNCLSGSRLKLATGYFNLTQEYMDTLTH 341
             |...::.|..||||:||::|....|..|.:||:.||:....|:::.|.||||||||.||| |..
  Rat   334 AAAAGDRRPAPDTWIYPLIQMKPFEIQIDEIVTETLLTEAERGAKVFLTTGYFNLTQAYMD-LVL 397

  Fly   342 KCLAQCSILMAHPNANGFQGAKGPAGGIPAAYTLIAKSFYESLVRRKQNHRVNFFEYEKPGWTYH 406
            ...|:..||:|.|..|||.||||.||.|||||..|.:.||..:....|..||...||.:.|||:|
  Rat   398 GTRAEYQILLASPEVNGFFGAKGVAGAIPAAYVHIERQFYSEVCSLGQQDRVQLQEYWRRGWTFH 462

  Fly   407 AKGLWYYLPEAILPNLTLIGSSNFGERSVNRDLETQVCLVTANKDLSQRLQAEADRLYDLSQTAE 471
            |||||.||..:.||.||||||.|||.|||:||||.|:.:||.::.|.|:|..|.::||..|....
  Rat   463 AKGLWLYLAGSSLPCLTLIGSPNFGYRSVHRDLEAQIAIVTESRALQQQLHQEQEQLYLRSGVVS 527

  Fly   472 REIVQRP---VPRWVQAVVRIFRNFF 494
            ....::|   |..||:.|..:.:|||
  Rat   528 SATFEQPGRQVKLWVKMVTPLIKNFF 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7718	NP_650751.3	PLDc_PGS1_euk_1	61..227	CDD:197233	90/172 (52%)
		PLDc_2	75..226	CDD:289836	86/157 (55%)
		PLDc_PGS1_euk_2	289..474	CDD:197235	92/184 (50%)
Pgs1	XP_006247917.1	PLDc_PGS1_euk_1	93..266	CDD:197233	90/172 (52%)
Pgs1	XP_006247917.1	PLDc_PGS1_euk_2	346..505	CDD:197235	85/159 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346220
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1502
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5467
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1934
OMA	1	1.010	-	-		QHG55277
OrthoDB	1	1.010	-	-		D1358866at2759
OrthoFinder	1	1.000	-	-		FOG0005130
OrthoInspector	1	1.000	-	-		oto96819
orthoMCL	1	0.900	-	-		OOG6_102888
Panther	1	1.100	-	-	LDO	PTHR12586
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4150
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770