DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7718 and pgs1

DIOPT Version :9

Sequence 1:	NP_650751.3	Gene:	CG7718 / 42254	FlyBaseID:	FBgn0038649	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_003199680.3	Gene:	pgs1 / 100534896	-ID:	-	Length:	540	Species:	Danio rerio

Alignment Length:	483	Identity:	223/483 - (46%)
Similarity:	306/483 - (63%)	Gaps:	29/483 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GFPGAPALES-LSWLHNLAPCFPLRGDQIQVIHEPKHFYETLVQRIGQAKRRIVLASLYLGTGQL 98
            ||.|..:|.| ..|:.:..|.|.:.|..|:|:|.|..||:.:..||..||.|:|:||||||||.|
Zfish    64 GFTGVESLHSRFHWMADHVPAFKVPGGHIRVLHSPDEFYQAMKARIKTAKSRVVMASLYLGTGPL 128

  Fly    99 ENAMVQTLRHSLEQQSA-----LRLNVLLDFTRGTRGTLNSKTMLLPLVRDFASQVQLSLYHTPD 158
            |..:|..:..:||:...     |:::.|||:|||:||..||:||||||::.|..|:::|||||||
Zfish   129 EQDLVDCMEEALERSQEDHTPDLKVSFLLDYTRGSRGKHNSRTMLLPLLQRFPEQMRVSLYHTPD 193

  Fly   159 LRGMTKRLAPPRWNELLGLQHMKVYLFDDAVIISGANLSNDYFTNRQDRYILIED-KPLADFYAQ 222
            |||:.:.|.|.|:||.:|:||:|.||||:::||||||||:.|||||||||:|:|| |.:|||:|:
Zfish   194 LRGLLRLLVPERFNETIGVQHIKAYLFDNSLIISGANLSDSYFTNRQDRYVLLEDCKEVADFFAE 258

  Fly   223 FIERVQEFSLAVAPDAS----EGLHRNWRILPYEGTKEQFIQLARKRISDLVQETFQRQARTKEQ 283
            .:..|.:.|:.:.||.|    ||     |:.||:|.:..|.:.|::||.::|.....||:..|.:
Zfish   259 LVGAVGDVSMQLLPDNSVEMMEG-----RVHPYKGNRADFSESAQRRIMEVVNTARIRQSMLKTE 318

  Fly   284 ---NPQA------DTWIFPLLEMGQIGIHHDSVVTKRLLSNCLSGSRLKLATGYFNLTQEYMDTL 339
               :|.:      |||||||::|..:|||.|..||||||:.....:.:.|.:||||||:.||. |
Zfish   319 CSDHPDSNGTSPNDTWIFPLVQMKPLGIHLDEQVTKRLLTEAGGDAVVYLTSGYFNLTRTYMQ-L 382

  Fly   340 THKCLAQCSILMAHPNANGFQGAKGPAGGIPAAYTLIAKSFYESLVRRKQNHRVNFFEYEKPGWT 404
            .....|...||||.|..|||.||||.||.||.||..:|:.||..:.:..|..||:..||.:|.||
Zfish   383 VLGAEADYRILMASPEVNGFFGAKGVAGAIPEAYVHLARQFYNKVCQLGQQSRVHLHEYHRPDWT 447

  Fly   405 YHAKGLWYYLPEAILPNLTLIGSSNFGERSVNRDLETQVCLVTANKDLSQRLQAEADRLYDLSQT 469
            :||||||||:.....|.||||||.|||.|||:||||.|:.:||.|::|..:||.|.:.||..|..
Zfish   448 FHAKGLWYYVGGRDCPCLTLIGSPNFGYRSVHRDLEAQIAIVTENEELQTQLQQEQEVLYQSSTQ 512

  Fly   470 AEREIVQRP---VPRWVQAVVRIFRNFF 494
            .......:|   |..||:.|..:.:|||
Zfish   513 VSNSTFNQPDRHVKLWVKLVTPLIKNFF 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7718	NP_650751.3	PLDc_PGS1_euk_1	61..227	CDD:197233	92/171 (54%)
		PLDc_2	75..226	CDD:289836	86/156 (55%)
		PLDc_PGS1_euk_2	289..474	CDD:197235	93/184 (51%)
pgs1	XP_003199680.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587186
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1502
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5467
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1849
OMA	1	1.010	-	-		QHG55277
OrthoDB	1	1.010	-	-		D1358866at2759
OrthoFinder	1	1.000	-	-		FOG0005130
OrthoInspector	1	1.000	-	-		oto41400
orthoMCL	1	0.900	-	-		OOG6_102888
Panther	1	1.100	-	-	LDO	PTHR12586
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R916
SonicParanoid	1	1.000	-	-		X4150
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800