DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7718 and pgs1

DIOPT Version :9

Sequence 1:	NP_650751.3	Gene:	CG7718 / 42254	FlyBaseID:	FBgn0038649	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001121526.2	Gene:	pgs1 / 100158650	XenbaseID:	XB-GENE-953426	Length:	531	Species:	Xenopus tropicalis

Alignment Length:	497	Identity:	227/497 - (45%)
Similarity:	305/497 - (61%)	Gaps:	38/497 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 QQAPSVLATGFPGAPALESLS--------WLHNLAPCFPLRGDQIQVIHEPKHFYETLVQRIGQA 82
            |.||.:.|.    .|||...|        |:.||.|.|.:....::|:..|..|||.:..:|..:
Frog    45 QSAPQITAK----YPALGCFSPHGTHQFQWIGNLVPEFGISSSNVKVLSTPSEFYEVMKAQIKTS 105

  Fly    83 KRRIVLASLYLGTGQLENAMVQTLRHSLE--QQSALRLNVLLDFTRGTRGTLNSKTMLLPLVRDF 145
            |:||.:||||||.|.||..:|.||..:|:  ..|.|::::|||:|||:||..||:||||||:..|
Frog   106 KKRITMASLYLGIGPLEQELVNTLEETLKCPDSSELQVSILLDYTRGSRGRKNSRTMLLPLLHRF 170

  Fly   146 ASQVQLSLYHTPDLRGMTKRLAPPRWNELLGLQHMKVYLFDDAVIISGANLSNDYFTNRQDRYIL 210
            ...|::||:|||.|||:.:.|.|.|:||.:||||||:|||||.:|:||||||:.|||||||||:|
Frog   171 PDNVRVSLFHTPHLRGLLRLLVPERFNETIGLQHMKIYLFDDNIILSGANLSDSYFTNRQDRYVL 235

  Fly   211 IED-KPLADFYAQFIERVQEFSLAVAPD----ASEGLHRNWRILPYEGTKEQFIQLARKRISDLV 270
            .:. ..||||::..:..|.|.||.:.||    ..||:..     ||:|.|.::.:.|.|::.:::
Frog   236 FQGCSELADFFSDLVGAVSEASLQLQPDDTVQVEEGMEH-----PYQGDKTKYCEAASKKVMEVI 295

  Fly   271 QETFQRQ---ARTKEQNPQA-------DTWIFPLLEMGQIGIHHDSVVTKRLLSNCLSGSRLKLA 325
            ::..:||   ..||.||.::       |||::||::|...||..|.:||:.||:....|.:|.|.
Frog   296 EDARRRQYEHRSTKFQNERSASDMEPPDTWVYPLVQMKPFGIQIDELVTETLLTEAERGDQLYLT 360

  Fly   326 TGYFNLTQEYMDTLTHKCLAQCSILMAHPNANGFQGAKGPAGGIPAAYTLIAKSFYESLVRRKQN 390
            ||||||||||||.|. ...|..:||:|.|..|||.||||.||.|||||..|...||..:.|..|.
Frog   361 TGYFNLTQEYMDLLL-GTRADYNILLAAPEVNGFFGAKGIAGAIPAAYVHIEHQFYSEVCRHGQE 424

  Fly   391 HRVNFFEYEKPGWTYHAKGLWYYLPEAILPNLTLIGSSNFGERSVNRDLETQVCLVTANKDLSQR 455
            .||...||.:..||:||||||:|...|.||.|||:||.|||.|||:||||.|:.|||.||:|.|:
Frog   425 MRVKLREYHRDLWTFHAKGLWFYSAGADLPCLTLVGSPNFGYRSVHRDLEAQIALVTENKELQQQ 489

  Fly   456 LQAEADRLYDLSQTAEREIVQRP---VPRWVQAVVRIFRNFF 494
            |..|..:||:||........|.|   |..||:.|..:.:|||
Frog   490 LHKEQQQLYNLSNAVSPATFQHPSRYVKLWVKLVTPLIKNFF 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7718	NP_650751.3	PLDc_PGS1_euk_1	61..227	CDD:197233	87/168 (52%)
		PLDc_2	75..226	CDD:289836	82/153 (54%)
		PLDc_PGS1_euk_2	289..474	CDD:197235	97/184 (53%)
pgs1	NP_001121526.2	Cls	80..522	CDD:224419	210/447 (47%)
		PLDc_PGS1_euk_1	84..253	CDD:197233	87/168 (52%)
		PLDc_PGS1_euk_2	324..485	CDD:197235	88/161 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4275
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5467
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1844
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1358866at2759
OrthoFinder	1	1.000	-	-		FOG0005130
OrthoInspector	1	1.000	-	-		oto103521
Panther	1	1.100	-	-	LDO	PTHR12586
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R916
SonicParanoid	1	1.000	-	-		X4150
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190