DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and MKK1

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_014874.1	Gene:	MKK1 / 854406	SGDID:	S000005757	Length:	508	Species:	Saccharomyces cerevisiae

Alignment Length:	502	Identity:	129/502 - (25%)
Similarity:	208/502 - (41%)	Gaps:	124/502 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1133 TSSPATSRSRT---PTRT-PMSAGMVLN-----PNTPPLQSPPYN-----KLLHPQ--------- 1174
            |..|.||.:.|   .||. |..:.|.||     |..|.|.|...|     |.| |:
Yeast    51 TPEPLTSSTSTLFSQTRLHPSDSSMTLNTMKKRPAPPSLPSLSINSQSKCKTL-PELVPIADVSD 114

  Fly  1175 ----FSLKE------DVSGTS-------YSPVD----SSDYVDTPCQRSANGELRLLV-----PQ 1213
                ..||:      ::||.|       .||..    ||.|:......|...:...|:     ..
Yeast   115 GKHDLGLKQRVIAENELSGNSDLTPSSMASPFSHTNTSSPYLRNDLSNSVGSDFSNLISAYEQSS 179

  Fly  1214 TPPTPASPGKSSLESTPLALRQERVRDAVNRLDMDLEDGLRERRLIGQVKSLNSSDKVHIRARSV 1278
            :|...:|..|||.||   .:....||| |::||   |:|.:...|..::::|
Yeast   180 SPIKSSSQPKSSSES---YIDLNSVRD-VDQLD---ENGWKYANLKDRIETL------------- 224

  Fly  1279 HFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVR 1343
                  || :|:|..|.|......|..::.|:|.|.....:....|.:..||:.....:.:.:||
Yeast   225 ------GI-LGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVR 282

  Fly  1344 YYGI--EVHREELLIFMELCSEGTLE----SLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVH 1402
            |||:  :.....:.|.||.....:|:    :|:|..|.:.|.:..:....:|.|:|.||:..::|
Yeast   283 YYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEKKVIH 347

  Fly  1403 RDIKTANIFLVDGSNSLKLGDF---GSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHG 1464
            ||||..|| |::.:..:||.||   |.||...|.|        :.||..|||||   :.....:.
Yeast   348 RDIKPQNI-LLNENGQVKLCDFGVSGEAVNSLATT--------FTGTSFYMAPE---RIQGQPYS 400

  Fly  1465 RAADIWSVGCVVVEMASGKRPW---------AQFDSNFQIM-FKVGMGEKPQAPESLSQEGHDFI 1519
            ..:|:||:|..::|:|:||.|.         |.|:....|: |...:.::|::....|.....||
Yeast   401 VTSDVWSLGLTILEVANGKFPCSSEKMAANIAPFELLMWILTFTPELKDEPESNIIWSPSFKSFI 465

  Fly  1520 DHCLQHDPKRRLTAVELLEHNFCKYGRDECSSEQLQMQVRGSFRRNV 1566
            |:||:.|.:.|.:..:::.|.:                ::|..::||
Yeast   466 DYCLKKDSRERPSPRQMINHPW----------------IKGQMKKNV 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	78/279 (28%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	78/277 (28%)
MKK1	NP_014874.1	PKc_like	219..506	CDD:419665	82/326 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343439
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840