Protein Alignment Mekk1 and BCK1

DIOPT Version :10

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_012440.1
• Gene: BCK1 / 853350
• SGDID: S000003631
• Length: 1478
• Species: Saccharomyces cerevisiae
• Alignment Length: 1327
• Identity: 294/1327 - (22%)
• Similarity: 500/1327 - (37%)
• Gaps: 353/1327 - (26%)

  Fly   384 YRREPSLISLDSGTHSDSNSNASSPLPSKMCQGCMSLYCKDCMDHQELALREVEGMLTRLEAAEA 448
            |||  |.||| .|:.|.:.|:|.||...|:           .:..:..::.|....||: .|:..
Yeast   297 YRR--SFISL-RGSSSSNASSAKSPSNIKL-----------SIPARPHSIIESNSTLTK-SASPP 346

  Fly   449 LYPSSQAMGALHPIYKSQSFVGRIKSMCLWYNI-----TKQNKLKLSILGKILARLQDEKFSWPV 508
            ..||..::...|  :||.|....:.:......|     ||.|....|:..:.||:.:.:.:...|
Yeast   347 ASPSYPSIFRRH--HKSSSSESSLLNSLFGSGIGEEAPTKPNPQGHSLSSENLAKGKSKHYETNV 409

  Fly   509 CTSSYIATDSGSSSASGVENDDSAVNSMDSSKPPSMAGSASRKGVTPCHKVQFMLNDATHVPG-E 572
                     |.....|.:...|...|..:..|..|..|..|.             |...:|.. |
Yeast   410 ---------SSPLKQSSLPTSDDKGNLWNKFKRKSQIGVPSP-------------NTVAYVTSQE 452

  Fly   573 TSS--SNESTST------EVSQWSSECSHSHMRKGSMHDINIFSVEPLGTCSSNGTGEQSTGLYR 629
            |.|  ||.||:|      :|:..|...|...:.|.:...:.:.|.|.....||.....:.|  |.
Yeast   453 TPSLKSNSSTATLTVQTADVNIPSPSSSPPPIPKTANRSLEVISTEDTPKISSTTASFKET--YP 515

  Fly   630 KFIE---------NVLKSRGLAKSLAFLHKLHNVALYKAHIALEKPGAEDFDYESDAESIEEDVP 685
            ..|.         |..|           :.:.|..|.:....|:|.|..  |.|:....:.:|..
Yeast   516 DCINPDKTVPVPVNNQK-----------YSVKNFLLDQKFYPLKKTGLN--DSENKYILVTKDNV 567

  Fly   686 RLDPEISREQVVELRTYGYWSEEAQSINLPSYIPTFVFL-------SGIP---LQFMHEFL---- 736
            ...| ::.:.|.:|.::...:.....||..:.  ||...       :.||   |:|:.:.|
Yeast   568 SFVP-LNLKSVAKLSSFKESALTKLGINHKNV--TFHMTDFDCDIGAAIPDDTLEFLKKSLFLNT 629

  Fly   737 --------RMRLETRPVRPNPLSLE--------QLMKELREGLTLALTHRERYQRHITTALVENE 785
                    :|:|:.:| :|.||:.|        :....:|.|.:..:...:      ..::|.:.
Yeast   630 SGKIYIKDQMKLQQKP-KPAPLTSENNVPLKSVKSKSSMRSGTSSLIASTD------DVSIVTSS 687

  Fly   786 AELGSYISILNHYDATVRKTFELYLEYIDQLVLVAVPE----GNQKSVLEKEWMFTKLI---SPM 843
            :::.|:.   .|...:.|:..:....|.|::......|    .|.|.||..|....|::   ||.
Yeast   688 SDITSFD---EHASGSGRRYPQTPSYYYDRVSNTNPTEELNYWNIKEVLSHEENAPKMVFKTSPK 749

  Fly   844 I------KGMHTLASQKFCGIISKL--LRSISERLVKRTVELDQQIDGT-ADTDDNEEVKWQL-- 897
            :      ||             |||  ...|:|...|.:.::.::.:|| .|.:...|..:..
Yeast   750 LELNLPDKG-------------SKLNIPTPITENESKSSFQVLRKDEGTEIDFNHRRESPYTKPE 801

  Fly   898 LTICRET----------QSLLTVERERSIKVLFFAKTFCRDVETTDFHREHYEHDVANQQHDFIC 952
            |...||.          ::|.|.::.:.|::
Yeast   802 LAPKREAPKPPANTSPQRTLSTSKQNKPIRL---------------------------------- 832

  Fly   953 SDVKAAFKLLQQDVLQVRNK------LTAIIEGVQKRCCLSNMRDLDEQDKQAVLSRTREILHQG 1011
              |:|:.|:.:..    |:|      |::.||        ::....|........:.|..::.|.
Yeast   833 --VRASTKISRSK----RSKPLPPQLLSSPIE--------ASSSSPDSLTSSYTPASTHVLIPQP 883

  Fly  1012 YKFGFEYHKDVIRLFEQKIMDQKDSGAHTVDLAL--------GIIAYAKMWMHFVMERCERGRGM 1068
            ||..    .||:|    ::...:||.:.:..|.:        ..::.:....:......:||...
Yeast   884 YKGA----NDVMR----RLKTDQDSTSTSPSLKMKQKVNRSNSTVSTSNSIFYSPSPLLKRGNSK 940

  Fly  1069 RPRWASQGLEF-----LILACDPQITQHLDDDEFEALKQQMDRCISHVIGITSEPEKVAKKKASP 1128
            |...::...:.     :..|..|.:....|.|:..:               :|:....:|||.:|
Yeast   941 RVVSSTSAADIFEENDITFADAPPMFDSDDSDDDSS---------------SSDDIIWSKKKTAP 990

  Fly  1129 RT-------RKTSSPATSRSR----TPTRTPMSAGMVLNPNTPPLQSPP--YNKL--LHPQFSLK 1178
            .|       .|:.:.:|....    :.|:..|...|...|      ||.  |..|  ..|:.:|.
Yeast   991 ETNNENKKDEKSDNSSTHSDEIFYDSQTQDKMERKMTFRP------SPEVVYQNLEKFFPRANLD 1049

  Fly  1179 EDVSGTSYSPVD--SSDYVDTPCQRSANGELRLLVPQTPPTPASPGKSSLESTPLALRQERVRDA 1241
            :.::....||..  |.|.:.:| :..|:....   |.||..|..|..|          .|.::|.
Yeast  1050 KPITEGIASPTSPKSLDSLLSP-KNVASSRTE---PSTPSRPVPPDSS----------YEFIQDG 1100

  Fly  1242 VNRLDMDLEDGLRER-----RLIGQVKSLNSSDKVHIRARSV----------------------- 1278
            :|..:..|......:     |.|....||...:.|.::.::.
Yeast  1101 LNGKNKPLNQAKTPKRTKTIRTIAHEASLARKNSVKLKRQNTKMWGTRMVEVTENHMVSINKAKN 1165

  Fly  1279 ------HFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAI--QPGETRALKNVAE----ELK 1331
                  .|.|.:|..||:|.||.||..:|..|||:||:|::.:  ...:..|:.:..|    |:.
Yeast  1166 SKGEYKEFAWMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVS 1230

  Fly  1332 ILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELH 1396
            .|:.:.|.|:|:|.|.|.......:|:|..:.|::.||:.:.|...|.|.:..|.|:|.|::.||
Yeast  1231 TLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLH 1295

  Fly  1397 KHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVK---IQAHTTVPGELQGYVGTQAYMAPE-VFTK 1457
            ..||:|||:|..|: |:|.....|:.|||.:.|   |.:::.:...     ||..:|||| |.||
Yeast  1296 SKGILHRDMKADNL-LLDQDGICKISDFGISRKSKDIYSNSDMTMR-----GTVFWMAPEMVDTK 1354

  Fly  1458 TNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQI---MFKVGMGEK-PQAPES----LSQE 1514
               .|:....||||:||:|:||.:|||||    ||.::   |||:|..:. |..||.    :||.
Yeast  1355 ---QGYSAKVDIWSLGCIVLEMFAGKRPW----SNLEVVAAMFKIGKSKSAPPIPEDTLPLISQI 1412

  Fly  1515 GHDFIDHCLQHDPKRRLTAVELLEHNF 1541
            |.:|:|.|.:.:|::|.||.|||.|.|
Yeast  1413 GRNFLDACFEINPEKRPTANELLSHPF 1439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	MEKK4_N	105..>930	CDD:466077	125/626 (20%)
		STKc_MEKK4	1281..1542	CDD:270796	103/279 (37%)
BCK1	NP_012440.1	STKc_Bck1_like	1173..1440	CDD:270799	104/280 (37%)