Protein Alignment Mekk1 and PBS2

DIOPT Version :10

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_012407.2
• Gene: PBS2 / 853313
• SGDID: S000003664
• Length: 668
• Species: Saccharomyces cerevisiae
• Alignment Length: 700
• Identity: 166/700 - (23%)
• Similarity: 268/700 - (38%)
• Gaps: 185/700 - (26%)

  Fly   995 QDKQAVLSRTREILHQGYKFGFEYHKDVIRLFEQKIMDQ-------KDSGAHTVDLALGIIAYAK 1052
            :||.|.||     ||:  |.|    |..|:|.||...|.       ..:.:|..::...:.|..|
Yeast     2 EDKFANLS-----LHE--KTG----KSSIQLNEQTGSDNGSAVKRTSSTSSHYNNINADLHARVK 55

  Fly  1053 MWMHFVMERC--------------ERGRGMRPRWASQ----GLEFLILACDPQITQHLDDDEFEA 1099
            .   |..:|.              ::|....|:...|    .|..|.:|...:::|.:.....:|
Yeast    56 A---FQEQRALKRSASVGSNQSEQDKGSSQSPKHIQQIVNKPLPPLPVAGSSKVSQRMSSQVVQA 117

  Fly  1100 -----LKQQMDRCISHVIGITSEPEKVAKKKASPRT--RKTSSPAT----SRSRTPTRTPMSAGM 1153
                 ||..:|.  .....||.....:...|.:..|  ..|..|||    |.|.|.:.|  ....
Yeast   118 SSKSTLKNVLDN--QETQNITDVNINIDTTKITATTIGVNTGLPATDITPSVSNTASAT--HKAQ 178

  Fly  1154 VLNPNTPPLQSPPYNKLLHPQFSLKEDVSGTSYSPVDSSDYVDTPCQR-SAN-------GELRLL 1210
            :||||....:.|     |..|...:.:|     :|..:...::||.|. ||.       |.:.|.
Yeast   179 LLNPNRRAPRRP-----LSTQHPTRPNV-----APHKAPAIINTPKQSLSARRGLKLPPGGMSLK 233

  Fly  1211 VP--------QTPPTP-------------------ASPGK--SSLESTPLALRQERVRDAVNRLD 1246
            :|        |..|:|                   ::||.  :.::||..:...|...|.|....
Yeast   234 MPTKTAQQPQQFAPSPSNKKHIETLSNSKVVEGKRSNPGSLINGVQSTSTSSSTEGPHDTVGTTP 298

  Fly  1247 --------------------------MDLEDGLRERRLIGQVKSLNSSDKVHIRARSVHFRWHRG 1285
                                      :|::.|           |||.:.|:.:.::.:.|.....
Yeast   299 RTGNSNNSSNSGSSGGGGLFANFSKYVDIKSG-----------SLNFAGKLSLSSKGIDFSNGSS 352

  Fly  1286 IKI-----------GQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHK 1339
            .:|           |.|.:|.|...::..|..:||.||:.::..|.: .:.:..||::|......
Yeast   353 SRITLDELEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAK-FRQILMELEVLHKCNSP 416

  Fly  1340 NLVRYYGIEVHREELLIFMELCSEGTLESLVELT---GNLPEALTRRFTAQLLSGVSEL-HKHGI 1400
            .:|.:||.......:.:.||....|:|:.:.:.:   |.:.|.........::.|:.|| .:|.|
Yeast   417 YIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSEIGGIDEPQLAFIANAVIHGLKELKEQHNI 481

  Fly  1401 VHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGEL-----QGYVGTQAYMAPEVFTKTNS 1460
            :|||:|..||.......::||.|||          |.|.|     :..:|.|:|||||.....|.
Yeast   482 IHRDVKPTNILCSANQGTVKLCDFG----------VSGNLVASLAKTNIGCQSYMAPERIKSLNP 536

  Fly  1461 DGHGRA-----ADIWSVGCVVVEMASGKRPW--AQFDSNFQIMFKVGMGEKPQAP-ESLSQEGHD 1517
            |   ||     :||||:|..::|||.|:.|:  ..:|:.|..:..:..|..|:.| :..|.:..|
Yeast   537 D---RATYTVQSDIWSLGLSILEMALGRYPYPPETYDNIFSQLSAIVDGPPPRLPSDKFSSDAQD 598

  Fly  1518 FIDHCLQHDPKRRLTAVELLEHNF-CKY-GRDECSSEQLQMQVRGSFRRN 1565
            |:..|||..|:||.|...|.||.: .|| .:|...||.:..::.   |||
Yeast   599 FVSLCLQKIPERRPTYAALTEHPWLVKYRNQDVHMSEYITERLE---RRN 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	MEKK4_N	105..>930	CDD:466077
		STKc_MEKK4	1281..1542	CDD:270796	81/289 (28%)
PBS2	NP_012407.2	PKc_PBS2_like	358..644	CDD:132953	85/302 (28%)