DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mekk1 and STE11

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_013466.1	Gene:	STE11 / 851076	SGDID:	S000004354	Length:	717	Species:	Saccharomyces cerevisiae

Alignment Length:	745	Identity:	171/745 - (22%)
Similarity:	284/745 - (38%)	Gaps:	185/745 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   921 FAKTFCRDVETTDFHREHYEHDVANQQHDFICSDVKAAFKLLQQDVLQVRNKLTAIIEGVQKRCC 985
            |.:.|..::..|.:.....:.::..::.          .|.|.:|:|        |..||.|
Yeast    24 FVQLFLEEIGCTQYLDSFIQCNLVTEEE----------IKYLDKDIL--------IALGVNK--- 67

  Fly   986 LSNMRDLDEQDKQAVLSRTREILHQGYKFGFEYHKDVIRLFEQKIMDQKDSGAHTVDLALGI-IA 1049
                    ..|:..:|.:::         .|:..|.:.::...|.:.:|.|...|..|::.. :.
Yeast    68 --------IGDRLKILRKSK---------SFQRDKRIEQVNRLKNLMEKVSSLSTATLSMNSELI 115

  Fly  1050 YAKMWMHFVM----------ERCERGRGMRPRWASQ-GLEFLILACDPQITQHLDDDEFEALKQQ 1103
            ..|..:.|::          ..|.....::.|...: ..|.|....:.::|:.:.|.:...|..
Yeast   116 PEKHCVIFILNDGSAKKVNVNGCFNADSIKKRLIRRLPHELLATNSNGEVTKMVQDYDVFVLDY- 179

  Fly  1104 MDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRTPMSAGMVLNPNTPPLQS---P 1165
                ..:|:.:..:.|.|....|:.|..|......|:.:||:...:|....|...|....|   |
Yeast   180 ----TKNVLHLLYDVELVTICHANDRVEKNRLIFVSKDQTPSDKAISTSKKLYLRTLSALSQVGP 240

  Fly  1166 PYNKLLHPQFSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRLLVPQTPPT-----------PA 1219
            ..:.||...       .|.|::..:....:|    .:....:|.:..|.||:           |.
Yeast   241 SSSNLLAQN-------KGISHNNAEGKLRID----NTEKDRIRQIFNQRPPSEFISTNLAGYFPH 294

  Fly  1220 SPGK----------------SSLESTPLALRQERVRDAV----NRLDMDLEDGLRERRLIGQVKS 1264
            :..|                |..:..||:.....:.|.:    |.:||.|..||.:.||..::.:
Yeast   295 TDMKRLQKTMRESFRHSARLSIAQRRPLSAESNNIGDILLKHSNAVDMALLQGLDQTRLSSKLDT 359

  Fly  1265 LNSSDKVHIRAR------------SVHF--------------------------RWHRGIKIGQG 1291
            .......|.|..            ||..                          .|.:|..||.|
Yeast   360 TKIPKLAHKRPEDNDAISNQLELLSVESGEEEDHDFFGEDSDIVSLPTKIATPKNWLKGACIGSG 424

  Fly  1292 RFGKVYTAVNNNTGELMAMKEIAIQ------PGETRALKNVAE---------------------- 1328
            .||.||..:|.:||||||:|::.|:      |.:.....|..|
Yeast   425 SFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIEDVGAVSHPKT 489

  Fly  1329 --------------ELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEA 1379
                          |:.:|:.:.|:|:|.|||.......|.||:|....|::.|::...|...|:
Yeast   490 NQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNYGPFEES 554

  Fly  1380 LTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYV 1444
            |...||.|:|.||:.|||..|:|||||.||| |:|....:|:.|||.:.|:........:.....
Yeast   555 LITNFTRQILIGVAYLHKKNIIHRDIKGANI-LIDIKGCVKITDFGISKKLSPLNKKQNKRASLQ 618

  Fly  1445 GTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAPE 1509
            |:..:|:|||..:|.:..   .|||||.||||:||.:||.|:..| |..|.:||:|....|:.|.
Yeast   619 GSVFWMSPEVVKQTATTA---KADIWSTGCVVIEMFTGKHPFPDF-SQMQAIFKIGTNTTPEIPS 679

  Fly  1510 SLSQEGHDFIDHCLQHDPKRRLTAVELLEH 1539
            ..:.||.:|:....:.|.:.|.:|:|||:|
Yeast   680 WATSEGKNFLRKAFELDYQYRPSALELLQH 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	101/301 (34%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	101/300 (34%)
STE11	NP_013466.1	SAM_Ste11_fungal	20..82	CDD:188933	13/95 (14%)
		Ras_bdg_2	121..224	CDD:405528	18/107 (17%)
		PKc_like	415..712	CDD:419665	101/300 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910