Protein Alignment Mekk1 and SSK22

DIOPT Version :10

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_009998.2
• Gene: SSK22 / 850436
• SGDID: S000000669
• Length: 1331
• Species: Saccharomyces cerevisiae
• Alignment Length: 1371
• Identity: 295/1371 - (21%)
• Similarity: 511/1371 - (37%)
• Gaps: 421/1371 - (30%)

  Fly   336 ELKDLIWLELQAWQADRTVEQQDKYLFEARQGVSDLLTHIINYKFQ-PRYRREPSLISLDSGTHS 399
            ||.|.|||||:||...||:::.::.|...|.....:...|:  ||| |    :..::|||
Yeast   187 ELSDEIWLELKAWLNGRTMQEMEQSLTYLRDSSDSVFEEIM--KFQIP----QGKILSLD----- 240

  Fly   400 DSNSNASSPLPSKMCQGCMSLYCKDCMDHQELALREV-EGMLTRLEAAEALYPSSQAMGALHPIY 463
                                            ||..: :.::.|..:..:.:|:.:.|....||.
Yeast   241 --------------------------------ALEAILQDLMNRYHSVVSYWPNLKKMYKDKPIT 273

  Fly   464 KSQSFVGRIKSMCLWYNITKQNKLKLSILGKILARLQDEKFSWPVCTSSYIATDSGSSSASGVEN 528
            .:..|..||..|..|.|.    |..|::      |.|:        ...:|...|..||:...:.
Yeast   274 NTAEFTARIDVMNSWLNF----KTNLTL------RRQE--------LDDWINRFSPISSSDNCQE 320

  Fly   529 DDSAVNSMDSSKPPSMAGSASRKGVTPCHKVQFMLNDATHVPGETSSSNESTSTEVSQWSSECS- 592
            |...|...:                  | |::.:...........|...:.....:|.|..:..
Yeast   321 DFDGVPQWN------------------C-KMKILAEQLMKEKNIESIFQKKIFYPLSPWMFKLKL 366

  Fly   593 HSHMRKGSMHDINI-FSVEPLGTCSSNGTGEQSTGLYRKFIENVLKSRGLAKSLAFLHKLHNVAL 656
            |..:.:.::..:|| :..|.|.:.       .:..:|  .|:.|:.:|     |::..||.|..:
Yeast   367 HFIVYRETLTKMNIKYPYERLRSL-------LAFPVY--LIKEVILTR-----LSYARKLKNPTM 417

  Fly   657 ---------YKAHIAL-------------EKPGAEDFDYESDAESIEE--------DVPRLD--- 688
                     :.|.|.|             ..|...|||...:...||.        ::..:|
Yeast   418 MMIDQMIDDFNAFIRLSVQLKYTLTKYCSNLPFDVDFDPTFENTVIEAIRYLFFLLNLKLIDSSK 482

  Fly   689 -----PEISREQVVELRTYGYWSEEAQSINLPSYIPTFVFLSGIPLQFMHE---FLRMRLETRPV 745
                 |::..:....|:..|::...|:::     ||. .||. :.|:.:|:   :|..:....|.
Yeast   483 QNFKAPDLLLKYWDHLKNTGHYINGAETV-----IPN-EFLK-LTLRLVHKLQFYLLKQQNFPPT 540

  Fly   746 RPNPLSLEQLMKELREGLTLALTHRERYQRHITTALVENEAELGSYISILNHYDATVRKTFE--L 808
            ..|....|:.:..:.|.|........|:...:..|. :|.|     :..:||....|:|..:  .
Yeast   541 FANASEAEKWLSSIFENLGAMKRKLNRFSNILVKAF-QNSA-----VYQINHNAQLVKKLKDAHY 599

  Fly   809 YLEYIDQLVLVAVPEGNQKSVLEKEWMFTKLISPMIKGMHTLASQKFCG----IISKLLR--SIS 867
            :|.|          .||   ..|.            .|::..|:.:..|    .|.::||  ||.
Yeast   600 FLVY----------SGN---TFES------------SGVYMFAAPELLGCDNDTILRILRNKSIG 639

  Fly   868 ERLVKRTVELDQQIDGTADTDDNEEVKWQLLTICRETQSLLTVERERSIKVLFFAKTFCRDVETT 932
            ..||.:           .|..:|..| :.:.|  :||...:.|.:....|.:.:.:.........
Yeast   640 CDLVPK-----------LDIGNNLNV-YDITT--KETDLNILVSKGEDSKGIPYYRVVANSSSDL 690

  Fly   933 DFH-----REHYEHDVANQQHDFICSDV---KAAFKLL--------------------------- 962
            |.|     ::::..|..:|..|...::|   :.|...|
Yeast   691 DRHAHQSKKKNFSTDPFDQHLDEKNNEVFELEVALSSLGALVVLYPGEPVVWDGPVYKLPGNNLF 755

  Fly   963 ---QQDVLQVRNKLTAII--EG----------------------VQKRCCLSNMRDLDEQDKQAV 1000
               :.|:.::.|..|.|:  :|                      ::|||.|:::....::..:|.
Yeast   756 ASNEMDLGKIGNPNTLILLNQGSNYALTYQIDKFNQTVGDSVSFIEKRCSLNSIESSLQKINKAY 820

  Fly  1001 LSRT--------------------REILHQGYKFGFEYHKDVIR--LFEQKIMDQKDSGAHTVDL 1043
            ...|                    .|:|:..:.||.::.:..::  .|..|         ....:
Yeast   821 YKLTYTVLNNYKGILGSFMKQCPGNELLNSIFMFGRDFGRSFLKYNAFSSK---------RKYVI 876

  Fly  1044 ALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQITQHLDDDEFEALKQQMDRC- 1107
            ...::.....|:.|::|.|:.......||....::|.:..........|:..:|:.||:::..|
Yeast   877 IFLMVKLGMNWLKFLVEECDPTDQRTFRWCVLAMDFAMQMTSGYNILALNVKQFQELKERVSVCM 941

  Fly  1108 ---ISH--VIGITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRTPMSAGMVLNPNTPPLQSPPY 1167
               |||  |:|..:                              |....||         |....
Yeast   942 SLLISHFDVMGARA------------------------------TEAENGM---------QQARL 967

  Fly  1168 NKLLHPQFSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRLLVPQTPPTPASPGKSSLESTPLA 1232
            |                    :|:.:.:|.......|..|||
Yeast   968 N--------------------IDTEENIDEEATLEINSRLRL----------------------- 989

  Fly  1233 LRQERVRDAVNRLDMDLEDGLRERRLIGQVKSLNSSDK-------VHIRARSVHFRWHRGIKIGQ 1290
                   :|:..|:..::   |..|.:|:|  |:::|:       :.....:|..||.:...||.
Yeast   990 -------EAIKTLEKTMK---RNPRQMGKV--LDATDQGNKYLLSLASSLSNVSMRWQKRSFIGG 1042

  Fly  1291 GRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKN----VAEELKILEGIKHKNLVRYYGIEVHR 1351
            |.||:||:|:|...||::|:|||.|.  :|..:|.    :.||:.:||.:.|.|:|:|||:||||
Yeast  1043 GTFGQVYSAINLENGEILAVKEIKIH--DTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHR 1105

  Fly  1352 EELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGS 1416
            :::.||||.|..|:|.||::......|.:|:.:|.:||.|::.||:.|:||||||..|| |:|.:
Yeast  1106 DKVNIFMEYCEGGSLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENI-LLDFN 1169

  Fly  1417 NSLKLGDFGSA---VKIQAHTTVPGELQGY----------VGTQAYMAPEVFTKTNSDGHGRAAD 1468
            ..:|..|||:|   |..:..|.....:|.:          :||..|||||..:.:...|...|.|
Yeast  1170 GIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKLGADD 1234

  Fly  1469 IWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAP--ESLSQEGHDFIDHCLQHDPKRRL 1531
            :|::||||:|||:|:|||:..|:.:.||:.|..|..||.|  :.::..|..|::.||..||..|.
Yeast  1235 VWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRA 1299

  Fly  1532 TAVELL 1537
            ||||||
Yeast  1300 TAVELL 1305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	MEKK4_N	105..>930	CDD:466077	120/646 (19%)
		STKc_MEKK4	1281..1542	CDD:270796	113/276 (41%)
SSK22	NP_009998.2	STKc_MEKK4	1033..1309	CDD:270796	113/276 (41%)