DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and MAP4K3

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_003609.2	Gene:	MAP4K3 / 8491	HGNCID:	6865	Length:	894	Species:	Homo sapiens

Alignment Length:	269	Identity:	97/269 - (36%)
Similarity:	145/269 - (53%)	Gaps:	31/269 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1287 KIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHR 1351
            :||.|.:|.||.|.|.|||||.|:|.|.::|||..|:  |.:|:.:::..||.|:|.|:|..:.|
Human    21 RIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV--VQQEIIMMKDCKHPNIVAYFGSYLRR 83

  Fly  1352 EELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGS 1416
            ::|.|.||.|..|:|:.:..:||.|.|......:.:.|.|:..||..|.:|||||.|||.|.|..
Human    84 DKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNG 148

  Fly  1417 NSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMAS 1481
            : :||.|||.:.:|   |....:.:.::||..:|||||.......|:.:..|:|:||...:|:|.
Human   149 H-VKLADFGVSAQI---TATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAE 209

  Fly  1482 GKRPWAQFD------------SNFQIMFKVGMGEKPQAPESL--SQEGHDFIDHCLQHDPKRRLT 1532
            .:.|  .||            ||||         .|:..:.:  |...|.|:...|..:||:|.|
Human   210 LQPP--MFDLHPMRALFLMTKSNFQ---------PPKLKDKMKWSNSFHHFVKMALTKNPKKRPT 263

  Fly  1533 AVELLEHNF 1541
            |.:||:|.|
Human   264 AEKLLQHPF 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	97/269 (36%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	96/267 (36%)
MAP4K3	NP_003609.2	STKc_MAP4K3_like	15..273	CDD:270788	97/269 (36%)
		S_TKc	16..273	CDD:214567	97/269 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..536
		CNH	561..874	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910