Protein Alignment Mekk1 and STK24

DIOPT Version :10

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_003567.2
• Gene: STK24 / 8428
• HGNCID: 11403
• Length: 443
• Species: Homo sapiens
• Alignment Length: 301
• Identity: 89/301 - (29%)
• Similarity: 147/301 - (48%)
• Gaps: 42/301 - (13%)

  Fly  1287 KIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHR 1351
            |||:|.||:|:..::|.|.:::|:|.|.::..|.. ::::.:|:.:|.......:.:|||..:..
Human    41 KIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYVTKYYGSYLKD 104

  Fly  1352 EELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGS 1416
            .:|.|.||....|:...|:| .|.|.|........::|.|:..||....:|||||.||:.|.: .
Human   105 TKLWIIMEYLGGGSALDLLE-PGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE-H 167

  Fly  1417 NSLKLGDFGSA-----VKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVV 1476
            ..:||.|||.|     .:|:.:|        :|||..:|||||..::..|.   .|||||:|...
Human   168 GEVKLADFGVAGQLTDTQIKRNT--------FVGTPFWMAPEVIKQSAYDS---KADIWSLGITA 221

  Fly  1477 VEMASGKRPWAQFDSNFQIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNF 1541
            :|:|.|:.|.::... .:::|.:.....|....:.|:...:|::.||..:|..|.||.|||:|.|
Human   222 IELARGEPPHSELHP-MKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 285

  Fly  1542 C---------------KYGR-------DECSSEQLQMQVRG 1560
            .               :|.|       |:.|||....:..|
Human   286 ILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDG 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	MEKK4_N	105..>930	CDD:466077
		STKc_MEKK4	1281..1542	CDD:270796	81/259 (31%)
STK24	NP_003567.2	STKc_MST3_like	34..307	CDD:270786	84/280 (30%)
		Bipartite nuclear localization signal	278..292		5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..337		5/18 (28%)
		Nuclear export signal (NES)	335..386