DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mekk1 and YDA

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_001319310.1	Gene:	YDA / 842674	AraportID:	AT1G63700	Length:	883	Species:	Arabidopsis thaliana

Alignment Length:	515	Identity:	172/515 - (33%)
Similarity:	247/515 - (47%)	Gaps:	92/515 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1118 PEKVAKKKASPRTRK-----------------TSSPATSRSRTPTRTPMSAGMVLNPNTPPLQSP 1165
            |.|.....||||.|.                 .|:|.:..| :|:|:||.:.:       |.|..
plant   197 PNKNRILSASPRRRPLGTHVKNLQIPQRDLVLCSAPDSLLS-SPSRSPMRSFI-------PDQVS 253

  Fly  1166 PYNKLLHPQFSLKEDV----SGTSYSPVDSSDYVDTPCQRSANGEL--RLLVPQT------PPTP 1218
            .:..|:...:|   ||    ||...||  .|.|  .....|..|::  :|..||:      .|.|
plant   254 NHGLLISKPYS---DVSLLGSGQCSSP--GSGY--NSGNNSIGGDMATQLFWPQSRCSPECSPVP 311

  Fly  1219 A----SPGKSS-LES---TPLALRQ--ERVRDAVNRLDMDLEDGLRERRL------------IGQ 1261
            :    |||.|| ::|   |||..|.  ........|||   ::..:..||            ...
plant   312 SPRMTSPGPSSRIQSGAVTPLHPRAGGSTTGSPTRRLD---DNRQQSHRLPLPPLLISNTCPFSP 373

  Fly  1262 VKSLNSSDKV---HIRAR---SVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAI---QP 1317
            ..|..:|..|   ..||.   |...||.:|..:|.|.||.||...|:.:||:.||||:.:   .|
plant   374 TYSAATSPSVPRSPARAEATVSPGSRWKKGRLLGMGSFGHVYLGFNSESGEMCAMKEVTLCSDDP 438

  Fly  1318 GETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTR 1382
            ....:.:.:.:|:.:|..::|:|:|:|||.|...::|.|::|..|.|::..|::..|...|...|
plant   439 KSRESAQQLGQEISVLSRLRHQNIVQYYGSETVDDKLYIYLEYVSGGSIYKLLQEYGQFGENAIR 503

  Fly  1383 RFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQ 1447
            .:|.|:|||::.||....||||||.||| |||....:|:.|||.|..|.|.:   |.| .:.|:.
plant   504 NYTQQILSGLAYLHAKNTVHRDIKGANI-LVDPHGRVKVADFGMAKHITAQS---GPL-SFKGSP 563

  Fly  1448 AYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMG-EKPQAPESL 1511
            .:|||||.  .||:|...|.||||:||.|:|||:.|.||:|:: ....|||:|.. |.|..|:.|
plant   564 YWMAPEVI--KNSNGSNLAVDIWSLGCTVLEMATTKPPWSQYE-GVPAMFKIGNSKELPDIPDHL 625

  Fly  1512 SQEGHDFIDHCLQHDPKRRLTAVELLEHNFCK----YGRDECSSEQLQ-MQVRGSFRRNV 1566
            |:||.||:..|||.:|..|.||.:||:|.|.:    ..|...|.|..: |.|..|..|::
plant   626 SEEGKDFVRKCLQRNPANRPTAAQLLDHAFVRNVMPMERPIVSGEPAEAMNVASSTMRSL 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	110/264 (42%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	109/262 (42%)
YDA	NP_001319310.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	209	1.000	Domainoid score	I802
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002637
OrthoInspector	1	1.000	-	-		otm2506
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48016
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010