DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and MAP3KA

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_564635.1	Gene:	MAP3KA / 841792	AraportID:	AT1G53570	Length:	609	Species:	Arabidopsis thaliana

Alignment Length:	472	Identity:	151/472 - (31%)
Similarity:	231/472 - (48%)	Gaps:	76/472 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1126 ASPRTRKTSSPATSRSRTPTR--TPM------------------SAGMVLNPNTPPLQSPPYNKL 1170
            ::.|..|:|:.......||||  ||.                  |.....:|...||.||   ..
plant    22 STDRDIKSSAVVVDPPLTPTRGGTPRCSREFAGASSAFSGFDSDSTEKKGHPLPRPLLSP---VS 83

  Fly  1171 LHPQFSLKEDVSG-TSYSPVDSSDYVDTPCQRSAN---GELRLLVPQTPPTP--ASPGKSSLEST 1229
            :|.|..:....|| ||.|.|.||...|...|..|:   |:::..|...|.:|  .||..:::.:.
plant    84 IHHQDHVSGSTSGSTSVSSVSSSGSADDQSQLVASRGRGDVKFNVAAAPRSPERVSPKAATITTR 148

  Fly  1230 PLALRQERVRDAVNRLDMDLEDGLRERRLIGQVKSLNSSDKVHIRAR---------SVH------ 1279
            |.:.|.:|:...|:     ||..      .|:.....||.:.|...|         :||
plant   149 PTSPRHQRLSGVVS-----LESS------TGRNDDGRSSSECHPLPRPPTSPTSPSAVHGSRIGG 202

  Fly  1280 ---------FRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEI-AIQPGET--RALKNVAEELKI 1332
                     ..|.:|..:|.|.||:||...|:..|::.|:||: .|...:|  ..||.:.:|:.:
plant   203 GYETSPSGFSTWKKGKFLGSGTFGQVYLGFNSEKGKMCAIKEVKVISDDQTSKECLKQLNQEINL 267

  Fly  1333 LEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHK 1397
            |..:.|.|:|:|||.|:..|.|.:::|..|.|::..|::..|:..|.:.:.:|.|:|:|::.||.
plant   268 LNQLCHPNIVQYYGSELSEETLSVYLEYVSGGSIHKLLKDYGSFTEPVIQNYTRQILAGLAYLHG 332

  Fly  1398 HGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDG 1462
            ...||||||.||| |||.:..:||.|||.|..:.|.:|    :..:.|:..:|||||....|  |
plant   333 RNTVHRDIKGANI-LVDPNGEIKLADFGMAKHVTAFST----MLSFKGSPYWMAPEVVMSQN--G 390

  Fly  1463 HGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMG-EKPQAPESLSQEGHDFIDHCLQHD 1526
            :..|.||||:||.::|||:.|.||:||: ....:||:|.. :.|:.|:.||.:..:||..|||.:
plant   391 YTHAVDIWSLGCTILEMATSKPPWSQFE-GVAAIFKIGNSKDTPEIPDHLSNDAKNFIRLCLQRN 454

  Fly  1527 PKRRLTAVELLEHNFCK 1543
            |..|.||.:||||.|.:
plant   455 PTVRPTASQLLEHPFLR 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	103/264 (39%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	103/262 (39%)
MAP3KA	NP_564635.1	STKc_MEKK1_plant	213..470	CDD:270802	103/264 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	209	1.000	Domainoid score	I802
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2506
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48016
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010