DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and MAPKKK9

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_192588.1	Gene:	MAPKKK9 / 826407	AraportID:	AT4G08480	Length:	773	Species:	Arabidopsis thaliana

Alignment Length:	727	Identity:	173/727 - (23%)
Similarity:	312/727 - (42%)	Gaps:	163/727 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   867 SERLVKRTVELDQQIDGTADTDDNEEVK--WQLLTICRETQSLLT-------VERERSIK-VLFF 921
            |..|:.|:::...:.....|..|:.|:.  :|.:.:.......::       :|.|||.. |:..
plant   143 SSLLITRSLDFPNRTSFRVDGVDDGEIDRIYQYIGVSGPEDFAISSDAWKARMEHERSSSDVVNK 207

  Fly   922 AKTFCRD----------VETTDFHREHYEHDVANQQHDFICSDVKAAFKLLQQDVLQVRNKL--T 974
            .|:...|          |.::..:.:...||::  :...|...|.:.|.|.:.:.::..|.|  .
plant   208 LKSLDLDSREAGPSGGVVASSSMNHKFQGHDLS--EAGSIGVVVASNFTLSESNKIENLNSLRDK 270

  Fly   975 AIIEG--VQKRCCLSNMRDLDEQDKQAVLSRTREILHQGYKFGFEYHKDVIRLFEQKIMDQKDSG 1037
            .|::|  |:.||.:        :.|..:|.::|         |:..|.|
plant   271 EIVDGDMVENRCGI--------ERKPTILVKSR---------GYLVHND---------------- 302

  Fly  1038 AHTVDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQITQHLDDDEFEALKQ 1102
              .|.:..||                  :|:||               |.:.....|      |:
plant   303 --DVGVGGGI------------------KGVRP---------------PVLNVPRAD------KE 326

  Fly  1103 QMD-RCISHVIGITSEPEKVAKKKA-----SPRTRKTSSPATSRSRTPTRTPMSAGMVLN----- 1156
            .:| ..:....||..:|..:.|.|.     ....:..:||..: .|...:..:.:|.|.|
plant   327 VVDGGTVESKSGIEWKPTILVKSKGYLVSNDGGIKGVTSPVLN-LRPTDKEVVDSGTVENRRGIK 390

  Fly  1157 ---PNTPPLQSPPYNKLLHPQFSLKEDVSGTS------YSPVDSSDYVDTPCQRSANGELRLLVP 1212
               |:.  |:.||..||  |..    |:.|:|      ::|  .|:.|..|...|:
plant   391 GVRPSV--LKPPPVMKL--PPV----DLPGSSWDILTHFAP--DSEIVRRPSSSSS--------- 436

  Fly  1213 QTPPTPASPGKSSLESTPLALRQERVRDAVNRLDMDLEDGLRERRLIGQVKS-LNSSDKVHIRAR 1276
                  :..|....|:....:.:|...|...:|:...::........|...| ::::..:.:...
plant   437 ------SENGCDEEEAEDDKVEKEETGDMFIQLEDTTDEACSFTTNEGDSSSTVSNTSPICVSGG 495

  Fly  1277 SVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRA---LKNVAEELKILEGIKH 1338
            |::..|.:|..:.||.||.||.|::.: |:..|:||:::....::|   ::.:..|:.:|..::|
plant   496 SINTSWQKGQLLRQGSFGSVYEAISED-GDFFAVKEVSLLDQGSQAQECIQQLEGEIALLSQLEH 559

  Fly  1339 KNLVRYYGIEVHREELLIFMELCSEGTLESLVEL--TGNLPEALTRRFTAQLLSGVSELHKHGIV 1401
            :|::||.|.:.....|.||:||.::|   ||:||  ...:.::|...:|.|:|.|:..||..|.:
plant   560 QNILRYRGTDKDGSNLYIFLELVTQG---SLLELYRRYQIRDSLISLYTKQILDGLKYLHHKGFI 621

  Fly  1402 HRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRA 1466
            |||||.|.| |||.:.::||.|||.| |:.....:....:    |..:|||||..:.::||:...
plant   622 HRDIKCATI-LVDANGTVKLADFGLA-KVSKLNDIKSRKE----TLFWMAPEVINRKDNDGYRSP 680

  Fly  1467 ADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRL 1531
            |||||:||.|:||.:|:.|::..:. .:.:|::..|..|:.|::||.:...||..||:.:|:.|.
plant   681 ADIWSLGCTVLEMCTGQIPYSDLEP-VEALFRIRRGTLPEVPDTLSLDARHFILKCLKLNPEERP 744

  Fly  1532 TAVELLEHNFCK 1543
            ||.|||.|.|.:
plant   745 TATELLNHPFVR 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	94/265 (35%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	94/263 (36%)
MAPKKK9	NP_192588.1	PKc_like	500..755	CDD:304357	94/265 (35%)
MAPKKK9	NP_192588.1	S_TKc	501..755	CDD:214567	94/264 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48016
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010