DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and MEKK3

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_192587.1	Gene:	MEKK3 / 826406	AraportID:	AT4G08470	Length:	560	Species:	Arabidopsis thaliana

Alignment Length:	523	Identity:	140/523 - (26%)
Similarity:	228/523 - (43%)	Gaps:	130/523 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1118 PEKVAKKKASPRTRKTSSPATSRSRTPTRTPMSAGMVL------------------NPNTPPLQS 1164
            |.|..|:::|..:..||      .:....|..:.||.:                  :.:|..:.|
plant    65 PSKTVKRQSSSSSDNTS------DKEEVETEETRGMFVQLGDTAHEACPFATNEADSSSTVSIIS 123

  Fly  1165 PPY------------NKLLHPQFSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRLLVP--QTP 1215
            |.|            .|.| .:.||.....|:|.|.|.|    ::.|.        |:.|  :.|
plant   124 PSYASRGSIVPSWLKRKFL-GRVSLGFVYEGSSGSSVGS----ESTCS--------LMTPSLEFP 175

  Fly  1216 P---------TPASPGKSSLESTPLALRQERVRDAVNRLDMDLEDGLRERRLIGQ---------- 1261
            .         :...|.:...|...|. |.:.:.:..|..|::......:.:|:|:
plant   176 DRISFRKKDFSEKGPSRHVWEKRKLT-RAKLIENFCNPEDIEPVTSWLKGQLLGEESFASVYEAI 239

  Fly  1262 --------------VKSLNSSDKVHIRARSV----------------------HFR-------WH 1283
                          ..|:...|::..|.|..                      :||       |.
plant   240 SDSSVGSESTCSLMTPSMEFPDRISFRKRDFSEEGPSGRVKEKRKLMRNKLIENFRKPEDITSWL 304

  Fly  1284 RGIKIGQGRFGKVYTAVNNNTGELMAMKEIA-----IQPGETRALKNVAEELKILEGIKHKNLVR 1343
            :|..:|:|.:..||.|::.: |:..|:||::     ||..|  .::.:..|:.:|..::|:|:||
plant   305 KGQLLGRGSYASVYEAISED-GDFFAVKEVSLLDKGIQAQE--CIQQLEGEIALLSQLQHQNIVR 366

  Fly  1344 YYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTA 1408
            |.|......:|.||:||.::|:::.|.| ...|...:...:|.|:|:|::.||..|.||||||.|
plant   367 YRGTAKDVSKLYIFLELVTQGSVQKLYE-RYQLSYTVVSLYTRQILAGLNYLHDKGFVHRDIKCA 430

  Fly  1409 NIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVG 1473
            |: |||.:.::||.|||     .|..:...::....||..:|||||..:.:|||:|..|||||:|
plant   431 NM-LVDANGTVKLADFG-----LAEASKFNDIMSCKGTLFWMAPEVINRKDSDGNGSPADIWSLG 489

  Fly  1474 CVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLE 1538
            |.|:||.:|:.|::.. ...|..||:|.|..|..|::||.:...||..||:.:|:.|.||.|||.
plant   490 CTVLEMCTGQIPYSDL-KPIQAAFKIGRGTLPDVPDTLSLDARHFILTCLKVNPEERPTAAELLH 553

  Fly  1539 HNF 1541
            |.|
plant   554 HPF 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	101/273 (37%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	99/263 (38%)
MEKK3	NP_192587.1	PKc_like	302..557	CDD:328722	100/266 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48016
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010