DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mekk1 and MAP3K19

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_011510193.1	Gene:	MAP3K19 / 80122	HGNCID:	26249	Length:	1345	Species:	Homo sapiens

Alignment Length:	1597	Identity:	333/1597 - (20%)
Similarity:	544/1597 - (34%)	Gaps:	532/1597 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 RDWERKQKVVNVTASADLPASVGGTPKKTRTARSRVLRRNTMDCALLNEMFVNDESKRTDKRLQS 197
            :||:.:.:.|.:|.:  .|..|  :|.:                          |..:.|.:.::
Human    88 QDWQPRTEGVEITVT--FPRDV--SPPQ--------------------------EMSQEDLKEKN 122

  Fly   198 LLRDSEREMKNSLATTAVAAPRGNSFHETAHPLESLDQIMPLNSEAMAPIPLRIASKVVESCNRY 262
            |:..|.:|...:              |..:||.|.....:......|.|:.|:......|.||
Human   123 LINSSLQEWAQA--------------HAVSHPNEIETVELRKKKLTMRPLVLQKEESSRELCN-- 171

  Fly   263 RCVSSRPIGYRSSAPPLAFAAQLPAGMLRSDGRATPGLGKRKDFHETFANLIKLGSVDRQDAKLS 327
                          ..|.|.  ||...|.                   .|:.|  ||.|:||
Human   172 --------------VNLGFL--LPRSCLE-------------------LNISK--SVTREDA--- 196

  Fly   328 QEEHTWQTELKDLIWLELQAWQADRTVEQQDKY-------------LFEARQGVSDLLTHIINYK 379
              .|          :|:.|..:::.......||             |...|.||   ||...|:|
Human   197 --PH----------FLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGV---LTIPQNHK 246

  Fly   380 F-QPRYRREPSLISL-----DSGTHSDSNSNASSP------------LPS--------KMCQGCM 418
            | :.:.|..|||.|.     .|...||..|.::.|            |.|        .||....
Human   247 FPKEKERNIPSLTSFVPKLSVSVRQSDELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPK 311

  Fly   419 SLYCKDCMDHQE-LALREVEGM----LTRLEAAEALYPSSQAMGALHPIYKSQSFVG--RIKSMC 476
            :.:.:.|::.:| ...:|:|..    :|..|                   |.||.|.  .:|.
Human   312 TNHHRQCLEKEENWKSKEIEECNKIEITHFE-------------------KGQSLVSFENLKE-- 355

  Fly   477 LWYNITKQNKLKLSILGKILARLQDEKFSWPVCTSSYIATDSGSSS-ASGVENDDSAVNSMDSSK 540
              .||....:..:...|....:.::|       .|.|:::....|| |...|.|...|.::
Human   356 --GNIPAVREEDIDCHGSKTRKPEEE-------NSQYLSSRKNESSVAKNYEQDPEIVCTI---- 407

  Fly   541 PPSMAGSASRKGVTPCHKVQFMLNDATHVPGETSSSNESTSTEVSQWSSECSHSHMRKGSMHDIN 605
             ||.........:||....:...|.|.   .:..|.:::.:.|.:....||:........:.|..
Human   408 -PSKFQETQHSEITPSQDEEMRNNKAA---SKRVSLHKNEAMEPNNILEECTVLKSLSSVVFDDP 468

  Fly   606 IFSVEPLGTCSSNGT------GEQSTGLYRKFI--------------ENVLKSRGLAKSLAFLHK 650
            |..: |.| |||..|      .|::.....:.:              |.|:....|......:|.
Human   469 IDKL-PEG-CSSMETNIKISIAERAKPEMSRMVPLIHITFPVDGSPKEPVIAKPSLQTRKGTIHN 531

  Fly   651 LHNVALYKAHIALEKPGAEDFDYESDAESIEEDVPRLDPEISREQVVELRTYGYWSEEAQSINLP 715
            .|:|.: ..|            .|:|...:.....:||                 |:...|...|
Human   532 NHSVNI-PVH------------QENDKHKMNSHRSKLD-----------------SKTKTSKKTP 566

  Fly   716 SYIPTFVFLSGIPLQ-FMHEFLRMRLETRP----VRPNPLSLEQLMKELREGLTLALTHR-ERYQ 774
            .   .||..:..|:: .||: ..::.:..|    |.|.|..|.:..|::.:......||| ::.:
Human   567 Q---NFVISTEGPIKPTMHK-TSIKTQIFPALGLVDPRPWQLPRFQKKMPQIAKKQSTHRTQKPK 627

  Fly   775 RHITTALVENEAELGSYISILNHYDATVRKTFELYLEYIDQLVLVAVPEGNQKSVLEKEWMFTKL 839
            :.....:.:|.....|.:.:      :|:.| |..|.|:|               |:...||.::
Human   628 KQSFPCICKNPGTQKSCVPL------SVQPT-EPRLNYLD---------------LKYSDMFKEI 670

  Fly   840 IS----PMIKGMHTLASQKFCGIISKLLRSISERLVKRTVELDQQI---------DGTADTDDNE 891
            .|    |.|..|  ..:..:|.:              |..|.|:..         .|...|:.
Human   671 NSTANGPGIYEM--FGTPVYCHV--------------RETERDENTYYREICSAPSGRRITNK-- 717

  Fly   892 EVKWQLLTICRETQSLLTVERERSIKVLFFAKTFCRDVETTDFHREHYEHDVANQQHDFICSDVK 956
                     ||.:.|    ||:.:|:.....|........|.|.        ..|:|..:.|..|
Human   718 ---------CRSSHS----ERKSNIRTRLSQKKTHMKCPKTSFG--------IKQEHKVLISKEK 761

  Fly   957 AAFKLLQQDVLQVRNKLTAIIEGVQKRCCLSNMRDLDEQDKQAVLSRTREILHQGYKFGFEYHKD 1021
            ::                        :...||:.|::..|  .:.....:|...|.:|
Human   762 SS------------------------KAVHSNLHDIENGD--GISEPDWQIKSSGNEF------- 793

  Fly  1022 VIRLFEQKIMDQKDSGAHTVDLA-----------------LGIIAYAKMWMHFVMERCERGRGMR 1069
                     :..||. .|.::||                 |.|:....|         |...|.|
Human   794 ---------LSSKDE-IHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSM---------EESTGDR 839

  Fly  1070 PRWASQGLEFLILACDPQITQHLDD-DEFEALKQQMDRCISHVIGITSE------PEKVAKKKAS 1127
            .           ::.:..:|..|.| .|.|.|..|       :..|.||      .||.:.|...
Human   840 D-----------ISNNQILTTSLRDLQELEELHHQ-------IPFIPSEDSWAVPSEKNSNKYVQ 886

  Fly  1128 PRTRKTSS-----------------PATSRSRTPTRTPMSAGMVLNPNTPPLQSPPY--NKLLHP 1173
            ...:.|:|                 ..:..|:|.|.....|    ...:...|:..|  :.|.|.
Human   887 QEKQNTASLSKVNASRILTNDLEFDSVSDHSKTLTNFSFQA----KQESASSQTYQYWVHYLDHD 947

  Fly  1174 QFSLK--------EDVSGTS------YSPVDSSDYVD------------------TPCQRSAN-- 1204
            ..:.|        :.:|||:      ...|::.:..|                  ..||:.||
Human   948 SLANKSITYQMFGKTLSGTNSISQEIMDSVNNEELTDELLGCLAAELLALDEKDNNSCQKMANET 1012

  Fly  1205 --GELRLLVPQTPPTPASPGKSSLESTPLALRQERVRDAVNRLDMDLEDGLR-----ERRLIGQV 1262
              ..|.|::.....||...|:   |:|.:.:::.             ..|||     |:.||...
Human  1013 DPENLNLVLRWRGSTPKEMGR---ETTKVKIQRH-------------SSGLRIYDREEKFLISNE 1061

  Fly  1263 K------SLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETR 1321
            |      ||.|.:.:         .|.:|..:|:|.:|.||..:.:. |:|:|:|::|:......
Human  1062 KKIFSENSLKSEEPI---------LWTKGEILGKGAYGTVYCGLTSQ-GQLIAVKQVALDTSNKL 1116

  Fly  1322 A----LKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTR 1382
            |    .:.:.||:.:|:.:||.|:|.|.|..:....:.||||....|::.|::...|.|||.:..
Human  1117 AAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFC 1181

  Fly  1383 RFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQ------AHTTVPGELQ 1441
            ::|.|:|.||:.||::.:||||||..|:.|:. :..:||.|||.|.::.      .|:.:   |:
Human  1182 KYTKQILQGVAYLHENCVVHRDIKGNNVMLMP-TGIIKLIDFGCARRLAWAGLNGTHSDM---LK 1242

  Fly  1442 GYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVG--MGEK 1504
            ...||..:|||||.   |..|:||.:||||:||.|.|||:||.|.|..| ....||.:|  .|..
Human  1243 SMHGTPYWMAPEVI---NESGYGRKSDIWSIGCTVFEMATGKPPLASMD-RMAAMFYIGAHRGLM 1303

  Fly  1505 PQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNF 1541
            |..|:..|:...||:..||..|...|.:|::||:|:|
Human  1304 PPLPDHFSENAADFVRMCLTRDQHERPSALQLLKHSF 1340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	99/273 (36%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	98/270 (36%)
MAP3K19	XP_011510193.1	STKc_YSK4	1076..1341	CDD:270801	99/283 (35%)
MAP3K19	XP_011510193.1	S_TKc	1078..1341	CDD:214567	99/272 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55144at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920