Protein Alignment Mekk1 and MAP2K4

DIOPT Version :10

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_001268364.1
• Gene: MAP2K4 / 6416
• HGNCID: 6844
• Length: 410
• Species: Homo sapiens
• Alignment Length: 382
• Identity: 100/382 - (26%)
• Similarity: 169/382 - (44%)
• Gaps: 79/382 - (20%)

  Fly  1212 PQTPPTPASPGKSSL-----------ESTPLALR--------QERVRDAVNRLDMDLEDGLRERR 1257
            |...|.|..|..||:           :|...||:        :...|..:|.....:::...||.
Human    23 PVGSPAPGHPAVSSMQGFQINFCEKAQSKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERL 87

  Fly  1258 LIGQVKSLNSSDKVHIRARSVHFRWH---RGIK----IGQGRFGKVYTAVNNNTGELMAMKEIAI 1315
               :..|:.||.|:.|   |....|.   ..:|    ||:|.:|.|...|:..:|::||:|.|..
Human    88 ---RTHSIESSGKLKI---SPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRS 146

  Fly  1316 QPGETRALKNVAEELKILEGIKHKN----LVRYYGIEVHREELLIFMELCSE----------GTL 1366
            ...|    |...:.|..|:.:...:    :|::||......:..|.|||.|.          ..|
Human   147 TVDE----KEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVL 207

  Fly  1367 ESLVELTGNLPEALTRRFTAQLLSGVSELHKH-GIVHRDIKTANIFLVDGSNSLKLGDFGSAVKI 1430
            :.::      ||.:..:.|...:..::.|.:: .|:|||||.:|| |:|.|.::||.|||
Human   208 DDVI------PEEILGKITLATVKALNHLKENLKIIHRDIKPSNI-LLDRSGNIKLCDFG----- 260

  Fly  1431 QAHTTVPGELQGYV------GTQAYMAPE-VFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQ 1488
                 :.|:|...:      |.:.||||| :....:..|:...:|:||:|..:.|:|:|:.|:.:
Human   261 -----ISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPK 320

  Fly  1489 FDSNFQIMFKVGMGEKPQAPESLSQEGH----DFIDHCLQHDPKRRLTAVELLEHNF 1541
            ::|.|..:.:|..|:.||...|..:|..    :|::.||..|..:|....|||:|.|
Human   321 WNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPF 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	MEKK4_N	105..>930	CDD:466077
		STKc_MEKK4	1281..1542	CDD:270796	81/294 (28%)
MAP2K4	NP_001268364.1	PKc_MKK4	106..396	CDD:270790	81/293 (28%)