DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and map3k19

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_017213290.1	Gene:	map3k19 / 572217	ZFINID:	ZDB-GENE-081104-140	Length:	1024	Species:	Danio rerio

Alignment Length:	797	Identity:	195/797 - (24%)
Similarity:	316/797 - (39%)	Gaps:	170/797 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   840 ISPMIKGMHTLASQKFCGIISKLLRSISERLVKRTVELDQQIDGTADTDDNEEVKWQLLTICR-E 903
            :.|..|..|.||.:                  |....||...:.....:.|:.||    .|.| |
Zfish   306 LQPTAKRCHFLAGE------------------KNIANLDMDTEEKYTHEKNKPVK----MIKRSE 348

  Fly   904 TQSLLTVERERSIKVLFFAKTFCRDVETTDFHREHYEHDVANQQHDFICSDVKAAFKLLQQDVLQ 968
            .:...:::..:|..||              .||        ||....|.|:   ......|..:|
Zfish   349 RKGKTSIQTNQSFNVL--------------AHR--------NQSTGKISSN---RINSPTQSKVQ 388

  Fly   969 VR-NKLTAIIEGVQKRCCLSNMRDLDE--------QDKQAVLSRTREILHQGYKFGFEYHKDVIR 1024
            :| ||.|::..|......::..::.||        :..|.|:|..::.||:..|..        |
Zfish   389 LRGNKPTSLAIGETTNKYVTCKKNADEGPTPRRVSEPFQHVVSNDQKQLHRDLKSA--------R 445

  Fly  1025 LFEQKIMDQKDSGAHTVDLALGIIAYAKMWMHFVMERCERGRGMRPRWASQGLEFLILACDPQIT 1089
            ..::.:..........||.|    .|..|::..       |:|      .:|.....:...|...
Zfish   446 APKKPVTGPAQRARSAVDYA----TYNDMFLKI-------GQG------DEGPAIYEMFATPLYE 493

  Fly  1090 QHLDDDEFEALKQ-----QMDRCISHVIGITSEPEKVAKKKASPRT----------RKTSSPATS 1139
            ....|...|..:|     |:.|.||..:......:...:||.|.|:          |...:.||.
Zfish   494 NLRADSSAERKRQIHTPLQVKRQISGKLKGQKTVDVNRRKKTSERSSRVKCRQLKHRDNLNKATK 558

  Fly  1140 RSRTPTRTPMSAGMVLNPNTPPLQSPPYNKLLHPQ----------------FSLKEDVSGTSYSP 1188
            :...|:.......:     |...::....|...|:                .|:.|:|...:.|.
Zfish   559 KHLPPSECKCHVLV-----TSASETSQRKKFERPEGEGKDISSVERQCTSILSVIEEVLSNTASK 618

  Fly  1189 VDSSDYV----DTPCQRSANGELRLL-VPQTPPTP-----ASPGKSS------LEST---PL--- 1231
            .:....:    .||.:.:||.|..:| |.:.|..|     .|.|.:|      ||..   ||
Zfish   619 ANLIKNIIHQEQTPLKANANREPEVLCVTRLPAQPLINTWTSDGTASPVYQRFLEGVGDGPLTDD 683

  Fly  1232 ---ALRQERV---RDAVNRLDMDLEDGLR-ERRLIGQVKSLN----SSDKVHIRARSVH---FRW 1282
               :|.:|.:   |..:..|..:.|||.. .|.|..:.|.|.    ||.|:|....|..   ..|
Zfish   684 LLRSLAEELLLLERRDIETLKTENEDGTEFNRDLHSKFKILQNEGVSSGKLHYTFGSCSGDAITW 748

  Fly  1283 HRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGET----RALKNVAEELKILEGIKHKNLVR 1343
            .:|..:|:|.:|.||..:.:. |:|:|:|::|:....:    :....:..|:.:|:.:||.|:|.
Zfish   749 TKGEVLGKGAYGTVYCGLTSQ-GQLIAVKQVALDASTSEIAEKEYDRLEREVDLLKNLKHTNIVG 812

  Fly  1344 YYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTA 1408
            :.|..:....:.||||....|::.:::...|.|||.:...::.|:|.||:.||.:.::|||:|..
Zfish   813 FLGTALSENIVSIFMEYIPGGSISNILGQFGPLPEKVFVLYSQQILEGVAYLHANRVIHRDLKGN 877

  Fly  1409 NIFLVDGSNSLKLGDFGSAVKIQAHTTVPGE----LQGYVGTQAYMAPEVFTKTNSDGHGRAADI 1469
            ||.|:. :..:||.|||.|.::....|..|.    |:...||..:|||||..:|   ||||.:||
Zfish   878 NIMLMP-TGVVKLIDFGCARRLSCLQTSTGSKGDLLKSVHGTPYWMAPEVINET---GHGRKSDI 938

  Fly  1470 WSVGCVVVEMASGKRPWAQFDSNFQIMFKVG--MGEKPQAPESLSQEGHDFIDHCLQHDPKRRLT 1532
            ||:||.|.|||:||.|.|.. :....::.:|  .|..|...:..|.:..||:..||..|.::|.:
Zfish   939 WSIGCTVFEMATGKPPLAHM-NKMAALYYIGARRGLMPSLSDDFSTDAKDFVQACLTRDQRQRPS 1002

  Fly  1533 AVELLEHNFCKYGRDEC 1549
            |.|||.|.|..:....|
Zfish  1003 AEELLRHPFISHHSKAC 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	91/270 (34%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	91/268 (34%)
map3k19	XP_017213290.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55144at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920