Protein Alignment Mekk1 and PAK6

DIOPT Version :9

• Sequence 1: NP_732373.1
• Gene: Mekk1 / 42253
• FlyBaseID: FBgn0024329
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_001263646.1
• Gene: PAK6 / 56924
• HGNCID: 16061
• Length: 681
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 147/538 - (27%)
• Similarity: 230/538 - (42%)
• Gaps: 94/538 - (17%)

  Fly  1090 QHLDDDEFEALKQ---QMDRCI-------SHVIGITSEPEKVAKK-------------------- 1124
            |.|...||:...|   |:..|:       |...|......|.||.
Human   178 QSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPG 242

  Fly  1125 ---KASPRTRKTSSP-----ATSRSRTPTRTPMSAGMVLNPNTPPLQSPPYNKLLHPQ------- 1174
               ..||:||::|..     :...|...|..|.|:    .|..|| ||.|.:....||
Human   243 GEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSS----KPGPPP-QSKPNSSFRPPQKDNPPSL 302

  Fly  1175 ----FSLKEDVSGTSYSPVDSSDYVDTPCQRSANGELRLLVPQTPPTPASPGKSSLESTPLALRQ 1235
                .||..|....::||:.:|| ..:| |:|    ||    ..|.|...||:||...:|   |.
Human   303 VAKAQSLPSDQPVGTFSPLTTSD-TSSP-QKS----LR----TAPATGQLPGRSSPAGSP---RT 354

  Fly  1236 ERVRDAVNRLDMDLEDGLRERRLIGQVKSLNSSDKVHIRARSV------HFRWHRGIKIGQGRFG 1294
            ...:.:.:.|.:..:..:.:..|.|:...:.:.::.....|.|      .......:|||:|..|
Human   355 WHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTG 419

  Fly  1295 KVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFME 1359
            .|..|...::|..:|:|.:.::..:.|.|  :..|:.|:...:|.|:|..|...:..|||.:.||
Human   420 IVCLAREKHSGRQVAVKMMDLRKQQRREL--LFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLME 482

  Fly  1360 LCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFL-VDGSNSLKLGD 1423
            ....|.|..:|... .|.|.........:|..::.||..|::|||||:.:|.| :||  .:||.|
Human   483 FLQGGALTDIVSQV-RLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDG--RVKLSD 544

  Fly  1424 FGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQ 1488
            ||...:|.  ..|| :.:..|||..:|||||.:::.   :....||||:|.:|:||..|:.|:..
Human   545 FGFCAQIS--KDVP-KRKSLVGTPYWMAPEVISRSL---YATEVDIWSLGIMVIEMVDGEPPYFS 603

  Fly  1489 FDSNFQIMFKVGMGEKPQAPES--LSQEGHDFIDHCLQHDPKRRLTAVELLEHNF-CKYGRDECS 1550
             ||..|.|.::.....|:...|  :|....||::..|..||:.|.||.|||:|.| .:.|..||.
Human   604 -DSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECL 667

  Fly  1551 SEQLQMQVRGSFRRNVAT 1568
            ...:|:     :|:..:|
Human   668 VPLIQL-----YRKQTST 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	87/264 (33%)
		S_TKc	1282..1541	CDD:214567	86/261 (33%)
PAK6	NP_001263646.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		PBD	11..67	CDD:307091
		Linker	26..406		54/245 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..169
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..256		9/55 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	268..355		31/104 (30%)
		STKc_PAK6	385..681	CDD:270821	95/313 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910