DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and pak6b

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_001155959.1	Gene:	pak6b / 567874	ZFINID:	ZDB-GENE-041014-121	Length:	607	Species:	Danio rerio

Alignment Length:	528	Identity:	140/528 - (26%)
Similarity:	224/528 - (42%)	Gaps:	107/528 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1096 EFEALKQQMDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRS------------------- 1141
            |:|.|.....|       .:|:..:.::...||:|....|||.:||
Zfish   129 EYEELNNTNHR-------NSSDLHRGSRPIQSPQTESRQSPARARSVHEATMFTGLMPRDILLHR 186

  Fly  1142 ----------RTPTRTPMSA------GMVLNPNTPPLQS-----PPYN-KLLHPQFSLKEDVSGT 1184
                      ..|.:.|:|.      |..||.:...:::     ..|: |:..|........:||
Zfish   187 AGCEGTDNAGNKPNQRPVSCLYSQSDGAKLNSDQLKMETQRRPQSTYDFKVNSPNLPAASKPNGT 251

  Fly  1185 SYSPVDSSDYV--DTPCQRSANGELRLL-----VPQTPPTPASP-----GKSSLESTPLALRQER 1237
            | ||......:  .||.:.|.:..|:|.     ||....:|:.|     |.||...|..::...:
Zfish   252 S-SPKPGHGIISMQTPRRSSTDNTLKLSTIPADVPPAQDSPSEPRQAPSGASSPGLTEPSVTHTQ 315

  Fly  1238 VRDAVNRLDMDLEDGLRERRLIGQVKSLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNN 1302
            .|.|   |.|.::.|                   ..|:...:|     ||||:|..|.|..|...
Zfish   316 FRAA---LQMVVDPG-------------------DPRSYLENF-----IKIGEGSTGVVCIAREK 353

  Fly  1303 NTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLE 1367
            ::|..:|:|.:.::..:.|.|  :..|:.|:...:|:|:|..|...:..|||.:.||....|.|.
Zfish   354 HSGRQVAVKMMDLRKQQRREL--LFNEVVIMRDYRHQNVVEMYKSALVGEELWVIMEYLQGGALT 416

  Fly  1368 SLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFL-VDGSNSLKLGDFGSAVKIQ 1431
            ::|..| .|.|.........:|..:..||..|::|||||:.:|.| :||  .:||.|||...:|.
Zfish   417 NIVSET-RLTEEQIATVCESVLQALCYLHSQGVIHRDIKSDSILLTLDG--RVKLSDFGFCAQIS 478

  Fly  1432 AHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIM 1496
              ..|| :.:..|||..:|||||.:||   .:|...||||:|.:||||..|:.|:.. ::....|
Zfish   479 --KDVP-KRRSLVGTPYWMAPEVVSKT---PYGTEVDIWSLGIMVVEMVDGEPPYFS-ETPISAM 536

  Fly  1497 FKVGMGEKPQA--PESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGRDECSSEQLQMQVR 1559
            .::.....|.|  ...:|....||:|..|..:|::|.:|.:||:|.|..    :|||.:..:.:.
Zfish   537 KRLRDEPPPTARNASKISPVLRDFLDSMLTREPQQRSSASDLLQHPFLL----QCSSPRCLIPLV 597

  Fly  1560 GSFRRNVA 1567
            ...||..:
Zfish   598 EQTRRRTS 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	87/263 (33%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	87/261 (33%)
pak6b	NP_001155959.1	PBD	13..65	CDD:279166
		STKc_PAK6	311..607	CDD:270821	100/338 (30%)
		S_TKc	338..584	CDD:214567	86/257 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910