DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mekk1 and map3k3

DIOPT Version :9

Sequence 1:	NP_732373.1	Gene:	Mekk1 / 42253	FlyBaseID:	FBgn0024329	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_688694.2	Gene:	map3k3 / 560211	ZFINID:	ZDB-GENE-070910-1	Length:	620	Species:	Danio rerio

Alignment Length:	688	Identity:	178/688 - (25%)
Similarity:	279/688 - (40%)	Gaps:	174/688 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   912 RERSIKVLFFAKTFCRDVETTDFHREHYEHDVANQQHDFICSDVKAAFKLLQQDVLQVRNKLTAI 976
            |...:::.|   .||.:.....|.|.        .|.:.:...||..|. .|.|:..:.|:|:.
Zfish    44 RLEDVRIKF---EFCGERRILMFGRP--------VQFEEVQQKVKTFFG-QQLDLHYMNNELSI- 95

  Fly   977 IEGVQKRCCLSNMRDLDEQDKQA-VLSRTREILHQGYKFGFEYHKDV-IRLFEQKIMDQKDSGAH 1039
                       .:||.|:.||.. :|.|:..:            |.: |.|..|:..:...|..|
Zfish    96 -----------PLRDQDDLDKAIDLLDRSSNM------------KSIKIMLLTQEQSNASSSSHH 137

  Fly  1040 TV-------------DLALGIIAYAKMWMHFVMERCERGRGMRP---------RWASQGLEFLIL 1082
            ||             |::....:......|........||...|         |.|.||....|
Zfish   138 TVCKQVRIKTSQSTGDVSTAYQSSEPRGRHHSTSSQNTGRSSPPPGYVPERQQRIARQGSYTSI- 201

  Fly  1083 ACDPQITQHLDDDEFEALKQQMDRCISHVIGITSEPEKVAKKKASPRTRKTSSPATSRSRTPTRT 1147
                       :.|.|.:.:..|:|   |:...|..|.............:.||:..:|||..
Zfish   202 -----------NSEGEFIPETSDQC---VLDPWSSAENSVSGSCQSLDSNSDSPSLRKSRTHR-- 250

  Fly  1148 PMSAGMVLNPNTPPLQSPP-------------YNKLL----------HPQFSLKEDVSGTSYSP- 1188
                          ::|.|             |:|::          |.....|:...|....|
Zfish   251 --------------IKSYPDNRQDCSDRENHVYDKIVGKGGTYPRRYHVSMHHKDHSEGRRTFPR 301

  Fly  1189 ---VDSSDYVDTPCQRSANGELRLLVPQTPPTPASPGKSSLESTPLALR-QERVRDAVNRLDMDL 1249
               ...:.:...|.:||.||           :..|.|...||:|...|| |:|.
Zfish   302 IRRPQGNLFTLVPSRRSLNG-----------SEESLGSWQLENTQSRLRPQDRA----------- 344

  Fly  1250 EDGLRERRLIGQVKSLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIA 1314
                                 |..::.:....|.||..:|||.||:||...:.:||..:|.|::.
Zfish   345 ---------------------VPHKSPTAPVTWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVH 388

  Fly  1315 IQPGETRALKNVAE---ELKILEGIKHKNLVRYYG-IEVHREE-LLIFMELCSEGTLESLVELTG 1374
            ..|......|.|:.   |:::|:.:.|:.:|:||| :..|.|: |.||||....|:::..::..|
Zfish   389 FDPASPETSKEVSALECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYG 453

  Fly  1375 NLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGE 1439
            .|.|.:||::|.|:|.|:|.||.:.|||||||.||| |.|.:.::||||||::.::|........
Zfish   454 ALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANI-LRDSAGNVKLGDFGASKRLQTICMSSTG 517

  Fly  1440 LQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVG-MGE 1503
            ::...||..:|:|||.   :.:|:||.||:||:||.||||.:.|.|||:|:: ...:||:. ...
Zfish   518 VRSVTGTPYWMSPEVI---SGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEA-MAAIFKIATQPT 578

  Fly  1504 KPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNF 1541
            .||.|..:|:...||: .|:..:.|.|.:|.|||.|.|
Zfish   579 NPQLPSHISEHTRDFL-RCIFVEAKYRPSAEELLRHPF 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mekk1	NP_732373.1	STKc_MEKK4	1281..1542	CDD:270796	104/267 (39%)
Mekk1	NP_732373.1	S_TKc	1282..1541	CDD:214567	103/264 (39%)
map3k3	XP_688694.2	PB1_Mekk2_3	48..126	CDD:99726	23/113 (20%)
		STKc_MEKK3_like	356..615	CDD:270795	103/264 (39%)
		S_TKc	356..615	CDD:214567	103/264 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55144at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920