DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mekk1 and PAK2

DIOPT Version :10

Sequence 1:NP_732373.1 Gene:Mekk1 / 42253 FlyBaseID:FBgn0024329 Length:1571 Species:Drosophila melanogaster
Sequence 2:NP_002568.2 Gene:PAK2 / 5062 HGNCID:8591 Length:524 Species:Homo sapiens


Alignment Length:511 Identity:136/511 - (26%)
Similarity:223/511 - (43%) Gaps:96/511 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  1111 VIGITSEPEKVAKKKASPRTRKTSSPATSRSRT-----PTRTPMSAGMVLNPNTPP-----LQSP 1165
            :|.|.|..||.:|||  .:.|...||.:....|     ...|....||      |.     ||:.
Human    53 IISIFSGTEKGSKKK--EKERPEISPPSDFEHTIHVGFDAVTGEFTGM------PEQWARLLQTS 109

  Fly  1166 PYNKL---LHPQFSLKEDV-----SGT------SYSPVDSSDYVD-TPCQRSANGELRLLVPQ-- 1213
            ...||   .:||..|  ||     |.|      |::|.:...:.. ||...:...|...:|.:  
Human   110 NITKLEQKKNPQAVL--DVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEE 172

  Fly  1214 --------------------------TPPTPASPGKSSLESTPLALRQERVRDAVNRLDMDLEDG 1252
                                      ..|.||..|.|.::....:|.:::.:..:.  |.::.:.
Human   173 DDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMT--DEEIMEK 235

  Fly  1253 LRERRLIGQVKSLNSSDKVHIRARSVHFRWHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQP 1317
            ||....||..|.                ::.|..|||||..|.|:||.:...|:.:|:|:|.:|.
Human   236 LRTIVSIGDPKK----------------KYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQK 284

  Fly  1318 GETRALKNVAEELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTR 1382
            ...:.|  :..|:.:::.:|:.|:|.:....:..:||.:.||..:.|:|..:|..| .:.||...
Human   285 QPKKEL--IINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTET-CMDEAQIA 346

  Fly  1383 RFTAQLLSGVSELHKHGIVHRDIKTANIFL-VDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGT 1446
            ....:.|..:..||.:.::|||||:.|:.| ::|  |:||.|||...:|   |....:....|||
Human   347 AVCRECLQALEFLHANQVIHRDIKSDNVLLGMEG--SVKLTDFGFCAQI---TPEQSKRSTMVGT 406

  Fly  1447 QAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKP--QAPE 1509
            ..:|||||.|:   ..:|...||||:|.:.:||..|:.|:.. ::..:.::.:.....|  |.||
Human   407 PYWMAPEVVTR---KAYGPKVDIWSLGIMAIEMVEGEPPYLN-ENPLRALYLIATNGTPELQNPE 467

  Fly  1510 SLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGRDECSSEQLQMQVRGSFRRN 1565
            .||....||::.||:.|.::|.:|.|||:|.|.|..:...|...|.|..:.:.:.|
Human   468 KLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSN 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mekk1NP_732373.1 MEKK4_N 105..>930 CDD:466077
STKc_MEKK4 1281..1542 CDD:270796 85/263 (32%)
PAK2NP_002568.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..81 11/29 (38%)
Autoregulatory region. /evidence=ECO:0000250|UniProtKB:Q13153 69..137 19/75 (25%)
GTPase-binding. /evidence=ECO:0000250|UniProtKB:Q13153 69..112 10/48 (21%)
PBD 73..130 CDD:395634 16/64 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..164 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..188 0/18 (0%)
STKc_PAK2 229..524 CDD:132986 97/323 (30%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:12853446 245..251 1/21 (5%)
Blue background indicates that the domain is not in the aligned region.

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